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A4FUQ9 (A4FUQ9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Akt1 protein EMBL AAI15584.1
Gene names
Name:Akt1 EMBL AAI15584.1 MGI 87986
OrganismMus musculus (Mouse) EMBL AAI15584.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length203 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS017892

Sequence similarities

Contains 1 AGC-kinase C-terminal domain. SAAS SAAS017892

Ontologies

Keywords
   LigandATP-binding SAAS SAAS017892
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase SAAS SAAS017892
Transferase
Gene Ontology (GO)
   Biological_processactivation-induced cell death of T cells

Inferred from sequence orthology PubMed 14749367. Source: MGI

anagen

Inferred from mutant phenotype PubMed 15713628. Source: MGI

apoptotic mitochondrial changes

Inferred from direct assay PubMed 12869584. Source: MGI

cell projection organization

Inferred from sequence orthology PubMed 16286931. Source: MGI

cellular response to growth factor stimulus

Inferred from direct assay PubMed 19744960. Source: MGI

cellular response to insulin stimulus

Inferred from direct assay PubMed 17715136. Source: MGI

germ cell development

Inferred from direct assay PubMed 12140361. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 19897600. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 19897600. Source: MGI

glycogen cell differentiation involved in embryonic placenta development

Inferred from mutant phenotype PubMed 12783884. Source: MGI

glycogen metabolic process

Inferred from mutant phenotype PubMed 12783884. Source: MGI

inflammatory response

Inferred from direct assay PubMed 14730361. Source: MGI

labyrinthine layer blood vessel development

Inferred from mutant phenotype PubMed 12783884. Source: MGI

maternal placenta development

Inferred from mutant phenotype PubMed 12783884. Source: MGI

negative regulation of cell size

Inferred from sequence orthology PubMed 16286931. Source: MGI

osteoblast differentiation

Inferred from genetic interaction PubMed 19208758. Source: MGI

peptidyl-serine phosphorylation

Inferred from direct assay PubMed 16513828. Source: MGI

peripheral nervous system myelin maintenance

Inferred from mutant phenotype PubMed 20448149. Source: MGI

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from mutant phenotype PubMed 15937334. Source: MGI

positive regulation of sodium ion transport

Inferred from mutant phenotype PubMed 17715136. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 18762576. Source: MGI

protein catabolic process

Inferred from direct assay PubMed 12145204. Source: MGI

protein kinase B signaling cascade

Inferred from genetic interaction PubMed 15249583. Source: MGI

protein ubiquitination

Inferred from direct assay PubMed 12145204. Source: MGI

regulation of protein localization

Inferred from direct assay PubMed 17715136. Source: MGI

response to food

Inferred from direct assay PubMed 16513828. Source: MGI

striated muscle cell differentiation

Inferred from genetic interaction PubMed 18762576. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12124386. Source: MGI

lamellipodium

Inferred from direct assay PubMed 12944902. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15775979. Source: MGI

spindle

Inferred from direct assay PubMed 15509711. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein kinase activity

Inferred from direct assay PubMed 14730361PubMed 15010863PubMed 15192701PubMed 16510873. Source: MGI

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAI15584.1

Sequences

Sequence LengthMass (Da)Tools
A4FUQ9 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 616FA4451C0EEE62

FASTA20323,290
        10         20         30         40         50         60 
QIHEDSRDGH IKITDFGLCK EGIKDGATMK TFCGTPEYLA PEVLEDNDYG RAVDWWGLGV 

        70         80         90        100        110        120 
VMYEMMCGRL PFYNQDHEKL FELILMEEIR FPRTLGPEAK SLLSGLLKKD PTQRLGGGSE 

       130        140        150        160        170        180 
DAKEIMQHRF FANIVWQDVY EKKLSPPFKP QVTSETDTRY FDEEFTAQMI TITPPDQDDS 

       190        200 
MECVDSERRP HFPQFSYSAS GTA

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PCR rescued clones EMBL AAI15584.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC115583 mRNA. Translation: AAI15584.1.
IPIIPI00323969.
UniGeneMm.6645.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:87986. Akt1.

Phylogenomic databases

HOVERGENHBG108317.
InParanoidA4FUQ9.

Gene expression databases

GenevestigatorA4FUQ9.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_cat_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAKT1. mouse.
NextBio35544751.
SOURCESearch...

Entry information

Entry nameA4FUQ9_MOUSE
AccessionPrimary (citable) accession number: A4FUQ9
Entry history
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info