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Protein

Formyl peptide receptor-related sequence 4

Gene

Fpr-rs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 4
Alternative name(s):
N-formylpeptide receptor-like 4
Gene namesi
Name:Fpr-rs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1278317. Fpr-rs4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 66CytoplasmicSequence analysisAdd BLAST16
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 99ExtracellularSequence analysisAdd BLAST12
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 202ExtracellularSequence analysisAdd BLAST37
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 241CytoplasmicSequence analysisAdd BLAST18
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 323CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820241 – 323Formyl peptide receptor-related sequence 4Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA4FUQ5.
PRIDEiA4FUQ5.

Expressioni

Tissue specificityi

Expressed in 0.6 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

BgeeiENSMUSG00000048062.
GenevisibleiA4FUQ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093311.

Structurei

3D structure databases

ProteinModelPortaliA4FUQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiA4FUQ5.
OMAiVHIIANI.
OrthoDBiEOG091G09ZK.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FUQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNISMPLN GSEVVFYDST TSRVLWILSL VVLFITFVLG VLGNGLVIWV
60 70 80 90 100
AGFQMAHTVT TVSYLNLALS DLSFMATLPL HIISMVMRGK WLFGWFLCKL
110 120 130 140 150
VHIIANINLF VSIFLITLIA MDRCICVLCP VWSQNHRTVS LARKVVLGAW
160 170 180 190 200
IFALLLTLPH FLFLTTVRDA RGDVYCISKF ESWVATSEEQ LKVSVIAATA
210 220 230 240 250
SGIINFIIGF SMPMSFIAIC YGLMAAKICR RGFVNSSRPL RVLTAVAVSF
260 270 280 290 300
FVCWFPFQLI MLLGNIFNNE TLSIIHMLVN PANTLASFNS CLNPILYVFL
310 320
GQEFRDRLIY SLYASLERAL RED
Length:323
Mass (Da):36,294
Last modified:July 27, 2011 - v2
Checksum:i17803E937AD10D9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23R → S in AAC34587 (PubMed:9722950).Curated1
Sequence conflicti23R → S in AAI15536 (PubMed:15489334).Curated1
Sequence conflicti76A → V in AAC34587 (PubMed:9722950).Curated1
Sequence conflicti193V → M in AAC34587 (PubMed:9722950).Curated1
Sequence conflicti248V → I in AAC34587 (PubMed:9722950).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
CCDSiCCDS49968.1.
RefSeqiNP_032067.2. NM_008041.2.
UniGeneiMm.455331.

Genome annotation databases

EnsembliENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneIDi14291.
KEGGimmu:14291.
UCSCiuc012alh.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
CCDSiCCDS49968.1.
RefSeqiNP_032067.2. NM_008041.2.
UniGeneiMm.455331.

3D structure databases

ProteinModelPortaliA4FUQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093311.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiA4FUQ5.
PRIDEiA4FUQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneIDi14291.
KEGGimmu:14291.
UCSCiuc012alh.1. mouse.

Organism-specific databases

CTDi14291.
MGIiMGI:1278317. Fpr-rs4.

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiA4FUQ5.
OMAiVHIIANI.
OrthoDBiEOG091G09ZK.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiA4FUQ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048062.
GenevisibleiA4FUQ5. MM.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRS4_MOUSE
AccessioniPrimary (citable) accession number: A4FUQ5
Secondary accession number(s): A4QMY2, E9QPJ4, O88538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.