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A4FUQ5

- FPRS4_MOUSE

UniProt

A4FUQ5 - FPRS4_MOUSE

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Protein
Formyl peptide receptor-related sequence 4
Gene
Fpr-rs4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 4
Alternative name(s):
N-formylpeptide receptor-like 4
Gene namesi
Name:Fpr-rs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1278317. Fpr-rs4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini51 – 6616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini88 – 9912Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 14424Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini166 – 20237Extracellular Reviewed prediction
Add
BLAST
Transmembranei203 – 22321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini224 – 24118Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini263 – 28018Extracellular Reviewed prediction
Add
BLAST
Transmembranei281 – 30121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini302 – 32322Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Formyl peptide receptor-related sequence 4
PRO_0000382024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 176 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA4FUQ5.

Expressioni

Tissue specificityi

Expressed in 0.6 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

BgeeiA4FUQ5.
GenevestigatoriA4FUQ5.

Structurei

3D structure databases

ProteinModelPortaliA4FUQ5.
SMRiA4FUQ5. Positions 30-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00730000110302.
HOGENOMiHOG000234122.
InParanoidiA4QMY2.
OMAiVHIIANI.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FUQ5-1 [UniParc]FASTAAdd to Basket

« Hide

MEVNISMPLN GSEVVFYDST TSRVLWILSL VVLFITFVLG VLGNGLVIWV    50
AGFQMAHTVT TVSYLNLALS DLSFMATLPL HIISMVMRGK WLFGWFLCKL 100
VHIIANINLF VSIFLITLIA MDRCICVLCP VWSQNHRTVS LARKVVLGAW 150
IFALLLTLPH FLFLTTVRDA RGDVYCISKF ESWVATSEEQ LKVSVIAATA 200
SGIINFIIGF SMPMSFIAIC YGLMAAKICR RGFVNSSRPL RVLTAVAVSF 250
FVCWFPFQLI MLLGNIFNNE TLSIIHMLVN PANTLASFNS CLNPILYVFL 300
GQEFRDRLIY SLYASLERAL RED 323
Length:323
Mass (Da):36,294
Last modified:July 27, 2011 - v2
Checksum:i17803E937AD10D9F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → S in AAC34587. 1 Publication
Sequence conflicti23 – 231R → S in AAI15536. 1 Publication
Sequence conflicti76 – 761A → V in AAC34587. 1 Publication
Sequence conflicti193 – 1931V → M in AAC34587. 1 Publication
Sequence conflicti248 – 2481V → I in AAC34587. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
CCDSiCCDS49968.1.
RefSeqiNP_032067.2. NM_008041.2.
UniGeneiMm.455331.

Genome annotation databases

EnsembliENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneIDi14291.
KEGGimmu:14291.
UCSCiuc012alh.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1 .
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1 .
BC115535 mRNA. Translation: AAI15536.1 .
CCDSi CCDS49968.1.
RefSeqi NP_032067.2. NM_008041.2.
UniGenei Mm.455331.

3D structure databases

ProteinModelPortali A4FUQ5.
SMRi A4FUQ5. Positions 30-305.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi A4FUQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095651 ; ENSMUSP00000093311 ; ENSMUSG00000048062 .
GeneIDi 14291.
KEGGi mmu:14291.
UCSCi uc012alh.1. mouse.

Organism-specific databases

CTDi 14291.
MGIi MGI:1278317. Fpr-rs4.

Phylogenomic databases

eggNOGi NOG150376.
GeneTreei ENSGT00730000110302.
HOGENOMi HOG000234122.
InParanoidi A4QMY2.
OMAi VHIIANI.
OrthoDBi EOG7PGDQQ.
TreeFami TF330976.

Miscellaneous databases

NextBioi 285689.
PROi A4FUQ5.
SOURCEi Search...

Gene expression databases

Bgeei A4FUQ5.
Genevestigatori A4FUQ5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
    Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
    Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS4_MOUSE
AccessioniPrimary (citable) accession number: A4FUQ5
Secondary accession number(s): A4QMY2, E9QPJ4, O88538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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