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A4FUQ5 (FPRS4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formyl peptide receptor-related sequence 4
Alternative name(s):
N-formylpeptide receptor-like 4
Gene names
Name:Fpr-rs4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in 0.6 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Ref.4 Ref.5

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Formyl peptide receptor-related sequence 4
PRO_0000382024

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 6616Cytoplasmic Potential
Transmembrane67 – 8721Helical; Name=2; Potential
Topological domain88 – 9912Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 14424Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 20237Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 24118Cytoplasmic Potential
Transmembrane242 – 26221Helical; Name=6; Potential
Topological domain263 – 28018Extracellular Potential
Transmembrane281 – 30121Helical; Name=7; Potential
Topological domain302 – 32322Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 176 By similarity

Experimental info

Sequence conflict231R → S in AAC34587. Ref.1
Sequence conflict231R → S in AAI15536. Ref.3
Sequence conflict761A → V in AAC34587. Ref.1
Sequence conflict1931V → M in AAC34587. Ref.1
Sequence conflict2481V → I in AAC34587. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A4FUQ5 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 17803E937AD10D9F

FASTA32336,294
        10         20         30         40         50         60 
MEVNISMPLN GSEVVFYDST TSRVLWILSL VVLFITFVLG VLGNGLVIWV AGFQMAHTVT 

        70         80         90        100        110        120 
TVSYLNLALS DLSFMATLPL HIISMVMRGK WLFGWFLCKL VHIIANINLF VSIFLITLIA 

       130        140        150        160        170        180 
MDRCICVLCP VWSQNHRTVS LARKVVLGAW IFALLLTLPH FLFLTTVRDA RGDVYCISKF 

       190        200        210        220        230        240 
ESWVATSEEQ LKVSVIAATA SGIINFIIGF SMPMSFIAIC YGLMAAKICR RGFVNSSRPL 

       250        260        270        280        290        300 
RVLTAVAVSF FVCWFPFQLI MLLGNIFNNE TLSIIHMLVN PANTLASFNS CLNPILYVFL 

       310        320 
GQEFRDRLIY SLYASLERAL RED 

« Hide

References

« Hide 'large scale' references
[1]"Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[5]"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ."
Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
RefSeqNP_032067.2. NM_008041.2.
UniGeneMm.455331.

3D structure databases

ProteinModelPortalA4FUQ5.
SMRA4FUQ5. Positions 26-305.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEA4FUQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneID14291.
KEGGmmu:14291.
UCSCuc012alh.1. mouse.

Organism-specific databases

CTD14291.
MGIMGI:1278317. Fpr-rs4.

Phylogenomic databases

eggNOGNOG150376.
GeneTreeENSGT00730000110302.
HOGENOMHOG000234122.
InParanoidA4QMY2.
OMAVHIIANI.
OrthoDBEOG7PGDQQ.
TreeFamTF330976.

Gene expression databases

BgeeA4FUQ5.
GenevestigatorA4FUQ5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000826. Formyl_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00526. FMETLEUPHER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285689.
PROA4FUQ5.
SOURCESearch...

Entry information

Entry nameFPRS4_MOUSE
AccessionPrimary (citable) accession number: A4FUQ5
Secondary accession number(s): A4QMY2, E9QPJ4, O88538
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries