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Protein

Formyl peptide receptor-related sequence 4

Gene

Fpr-rs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 4
Alternative name(s):
N-formylpeptide receptor-like 4
Gene namesi
Name:Fpr-rs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1278317. Fpr-rs4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 6616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 9912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 24118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Formyl peptide receptor-related sequence 4PRO_0000382024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA4FUQ5.

Expressioni

Tissue specificityi

Expressed in 0.6 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

BgeeiA4FUQ5.
GenevestigatoriA4FUQ5.

Structurei

3D structure databases

ProteinModelPortaliA4FUQ5.
SMRiA4FUQ5. Positions 30-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiA4FUQ5.
OMAiVHIIANI.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FUQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNISMPLN GSEVVFYDST TSRVLWILSL VVLFITFVLG VLGNGLVIWV
60 70 80 90 100
AGFQMAHTVT TVSYLNLALS DLSFMATLPL HIISMVMRGK WLFGWFLCKL
110 120 130 140 150
VHIIANINLF VSIFLITLIA MDRCICVLCP VWSQNHRTVS LARKVVLGAW
160 170 180 190 200
IFALLLTLPH FLFLTTVRDA RGDVYCISKF ESWVATSEEQ LKVSVIAATA
210 220 230 240 250
SGIINFIIGF SMPMSFIAIC YGLMAAKICR RGFVNSSRPL RVLTAVAVSF
260 270 280 290 300
FVCWFPFQLI MLLGNIFNNE TLSIIHMLVN PANTLASFNS CLNPILYVFL
310 320
GQEFRDRLIY SLYASLERAL RED
Length:323
Mass (Da):36,294
Last modified:July 27, 2011 - v2
Checksum:i17803E937AD10D9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → S in AAC34587 (PubMed:9722950).Curated
Sequence conflicti23 – 231R → S in AAI15536 (PubMed:15489334).Curated
Sequence conflicti76 – 761A → V in AAC34587 (PubMed:9722950).Curated
Sequence conflicti193 – 1931V → M in AAC34587 (PubMed:9722950).Curated
Sequence conflicti248 – 2481V → I in AAC34587 (PubMed:9722950).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
CCDSiCCDS49968.1.
RefSeqiNP_032067.2. NM_008041.2.
UniGeneiMm.455331.

Genome annotation databases

EnsembliENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneIDi14291.
KEGGimmu:14291.
UCSCiuc012alh.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071182 Genomic DNA. Translation: AAC34587.1.
AC171405 Genomic DNA. No translation available.
BC115534 mRNA. Translation: AAI15535.1.
BC115535 mRNA. Translation: AAI15536.1.
CCDSiCCDS49968.1.
RefSeqiNP_032067.2. NM_008041.2.
UniGeneiMm.455331.

3D structure databases

ProteinModelPortaliA4FUQ5.
SMRiA4FUQ5. Positions 30-305.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiA4FUQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095651; ENSMUSP00000093311; ENSMUSG00000048062.
GeneIDi14291.
KEGGimmu:14291.
UCSCiuc012alh.1. mouse.

Organism-specific databases

CTDi14291.
MGIiMGI:1278317. Fpr-rs4.

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiA4FUQ5.
OMAiVHIIANI.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi285689.
PROiA4FUQ5.
SOURCEiSearch...

Gene expression databases

BgeeiA4FUQ5.
GenevestigatoriA4FUQ5.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
    Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
    Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS4_MOUSE
AccessioniPrimary (citable) accession number: A4FUQ5
Secondary accession number(s): A4QMY2, E9QPJ4, O88538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.