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A4FUN7 (UBP12_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 12A

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 12A
Ubiquitin thioesterase 12A
Ubiquitin-specific-processing protease 12A
Gene names
Name:usp12a
Synonyms:usp12
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family. USP12/USP46 subfamily.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Ubiquitin carboxyl-terminal hydrolase 12A
PRO_0000378991

Regions

Domain39 – 370332USP

Sites

Active site481Nucleophile By similarity
Active site3181Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A4FUN7 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 930E27CEBE0C8A53

FASTA37143,027
        10         20         30         40         50         60 
MEILMTVSKF ASFCTMGANA SALEKEIGSE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 

        70         80         90        100        110        120 
RPFREKILAY RSQPRRKENL LTCLADLFHS IANQKRKVGV IPPKKFITRL RKENELFDNY 

       130        140        150        160        170        180 
MQQDAHEFLN YLLNTIADLL QEERKQDKQN GKLANGTLDS QNNNSTPPST TWVHEIFQGT 

       190        200        210        220        230        240 
LTNETRCLTC ETISSKDEDF LDLSVDVEQN TSITHCLRGF SNTETLCSEY KYYCEECRSK 

       250        260        270        280        290        300 
QEAHKRMRVK KLPMILALHL KRFKYMEQLQ RYTKLSYRVV FPLELRLFNT SGDATNPERL 

       310        320        330        340        350        360 
YDLVAVVVHC GSGPNRGHYI AIVKSHDFWL LFDDDIVEKI DAQAIEEFYG LTSEISKNSE 

       370 
SGYILFYQSR D 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC115286 mRNA. Translation: AAI15287.1.
RefSeqNP_001077025.1. NM_001083556.1.
UniGeneDr.5972.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000103890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000112670; ENSDARP00000103890; ENSDARG00000078109.
GeneID565736.
KEGGdre:565736.

Organism-specific databases

CTD565736.
ZFINZDB-GENE-060228-3. usp12a.

Phylogenomic databases

eggNOGCOG5077.
GeneTreeENSGT00650000093027.
HOGENOMHOG000231498.
KOK11842.
OMASKFASFC.
OrthoDBEOG7RBZ8G.
PhylomeDBA4FUN7.
TreeFamTF314144.

Gene expression databases

BgeeA4FUN7.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20886545.
PROA4FUN7.

Entry information

Entry nameUBP12_DANRE
AccessionPrimary (citable) accession number: A4FUN7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries