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A4FUN7

- UBP12_DANRE

UniProt

A4FUN7 - UBP12_DANRE

Protein

Ubiquitin carboxyl-terminal hydrolase 12A

Gene

usp12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481NucleophilePROSITE-ProRule annotation
    Active sitei318 – 3181Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. protein deubiquitination Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 12A (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 12A
    Ubiquitin thioesterase 12A
    Ubiquitin-specific-processing protease 12A
    Gene namesi
    Name:usp12a
    Synonyms:usp12
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 24

    Organism-specific databases

    ZFINiZDB-GENE-060228-3. usp12a.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Ubiquitin carboxyl-terminal hydrolase 12APRO_0000378991Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA4FUN7.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000103890.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 370332USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00650000093027.
    HOGENOMiHOG000231498.
    KOiK11842.
    OMAiSKFASFC.
    OrthoDBiEOG7RBZ8G.
    PhylomeDBiA4FUN7.
    TreeFamiTF314144.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FUN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEILMTVSKF ASFCTMGANA SALEKEIGSE QFPVNEHYFG LVNFGNTCYC    50
    NSVLQALYFC RPFREKILAY RSQPRRKENL LTCLADLFHS IANQKRKVGV 100
    IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADLL QEERKQDKQN 150
    GKLANGTLDS QNNNSTPPST TWVHEIFQGT LTNETRCLTC ETISSKDEDF 200
    LDLSVDVEQN TSITHCLRGF SNTETLCSEY KYYCEECRSK QEAHKRMRVK 250
    KLPMILALHL KRFKYMEQLQ RYTKLSYRVV FPLELRLFNT SGDATNPERL 300
    YDLVAVVVHC GSGPNRGHYI AIVKSHDFWL LFDDDIVEKI DAQAIEEFYG 350
    LTSEISKNSE SGYILFYQSR D 371
    Length:371
    Mass (Da):43,027
    Last modified:April 17, 2007 - v1
    Checksum:i930E27CEBE0C8A53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115286 mRNA. Translation: AAI15287.1.
    RefSeqiNP_001077025.1. NM_001083556.1.
    UniGeneiDr.5972.

    Genome annotation databases

    EnsembliENSDART00000112670; ENSDARP00000103890; ENSDARG00000078109.
    GeneIDi565736.
    KEGGidre:565736.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115286 mRNA. Translation: AAI15287.1 .
    RefSeqi NP_001077025.1. NM_001083556.1.
    UniGenei Dr.5972.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000103890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000112670 ; ENSDARP00000103890 ; ENSDARG00000078109 .
    GeneIDi 565736.
    KEGGi dre:565736.

    Organism-specific databases

    CTDi 565736.
    ZFINi ZDB-GENE-060228-3. usp12a.

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00650000093027.
    HOGENOMi HOG000231498.
    KOi K11842.
    OMAi SKFASFC.
    OrthoDBi EOG7RBZ8G.
    PhylomeDBi A4FUN7.
    TreeFami TF314144.

    Miscellaneous databases

    NextBioi 20886545.
    PROi A4FUN7.

    Gene expression databases

    Bgeei A4FUN7.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiUBP12_DANRE
    AccessioniPrimary (citable) accession number: A4FUN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3