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A4FUN7

- UBP12_DANRE

UniProt

A4FUN7 - UBP12_DANRE

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Protein

Ubiquitin carboxyl-terminal hydrolase 12A

Gene
usp12a, usp12
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481Nucleophile By similarity
Active sitei318 – 3181Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 12A (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 12A
Ubiquitin thioesterase 12A
Ubiquitin-specific-processing protease 12A
Gene namesi
Name:usp12a
Synonyms:usp12
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-060228-3. usp12a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Ubiquitin carboxyl-terminal hydrolase 12APRO_0000378991Add
BLAST

Expressioni

Gene expression databases

BgeeiA4FUN7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 370332USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00650000093027.
HOGENOMiHOG000231498.
KOiK11842.
OMAiSKFASFC.
OrthoDBiEOG7RBZ8G.
PhylomeDBiA4FUN7.
TreeFamiTF314144.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FUN7-1 [UniParc]FASTAAdd to Basket

« Hide

MEILMTVSKF ASFCTMGANA SALEKEIGSE QFPVNEHYFG LVNFGNTCYC    50
NSVLQALYFC RPFREKILAY RSQPRRKENL LTCLADLFHS IANQKRKVGV 100
IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADLL QEERKQDKQN 150
GKLANGTLDS QNNNSTPPST TWVHEIFQGT LTNETRCLTC ETISSKDEDF 200
LDLSVDVEQN TSITHCLRGF SNTETLCSEY KYYCEECRSK QEAHKRMRVK 250
KLPMILALHL KRFKYMEQLQ RYTKLSYRVV FPLELRLFNT SGDATNPERL 300
YDLVAVVVHC GSGPNRGHYI AIVKSHDFWL LFDDDIVEKI DAQAIEEFYG 350
LTSEISKNSE SGYILFYQSR D 371
Length:371
Mass (Da):43,027
Last modified:April 17, 2007 - v1
Checksum:i930E27CEBE0C8A53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC115286 mRNA. Translation: AAI15287.1.
RefSeqiNP_001077025.1. NM_001083556.1.
UniGeneiDr.5972.

Genome annotation databases

EnsembliENSDART00000112670; ENSDARP00000103890; ENSDARG00000078109.
GeneIDi565736.
KEGGidre:565736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC115286 mRNA. Translation: AAI15287.1 .
RefSeqi NP_001077025.1. NM_001083556.1.
UniGenei Dr.5972.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000103890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000112670 ; ENSDARP00000103890 ; ENSDARG00000078109 .
GeneIDi 565736.
KEGGi dre:565736.

Organism-specific databases

CTDi 565736.
ZFINi ZDB-GENE-060228-3. usp12a.

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00650000093027.
HOGENOMi HOG000231498.
KOi K11842.
OMAi SKFASFC.
OrthoDBi EOG7RBZ8G.
PhylomeDBi A4FUN7.
TreeFami TF314144.

Miscellaneous databases

NextBioi 20886545.
PROi A4FUN7.

Gene expression databases

Bgeei A4FUN7.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUBP12_DANRE
AccessioniPrimary (citable) accession number: A4FUN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi