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Protein

Peroxisome assembly protein 12

Gene

PEX12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for protein import into peroxisomes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:PEX12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 158CytoplasmicSequence analysisAdd BLAST158
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 239Peroxisomal matrixSequence analysisAdd BLAST60
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 359CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561901 – 359Peroxisome assembly protein 12Add BLAST359

Proteomic databases

PaxDbiA4FUD4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019723.

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026285.

Structurei

3D structure databases

ProteinModelPortaliA4FUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 285Poly-Pro6

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiA4FUD4.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG091G0BN4.
TreeFamiTF314511.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHGAHITT ASVVDDQPSI FEVVAQDSLM SAVRPALQHV VKVLAESNPA
60 70 80 90 100
HFGFFWRWFD EIFTLLDLLL QQHYLSKTSA SFSENFYGLK RIVMGDQHKL
110 120 130 140 150
QRLANAGLPK QQFMKSIMFL VLLPYLKVKL EKLVSSLREE DEYSIHPPSS
160 170 180 190 200
RWKRFYRAFL AAYPFVNMAW EGWFLVQQLR YILGKAQHHS PLLRLAGVRL
210 220 230 240 250
GRLTVQDIQA LEHKPAEASM MQLPAGSIGE KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LEWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKN RVNDTVLATS GYVFCYRCVF HYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,766
Last modified:April 17, 2007 - v1
Checksum:iF226003755C8E3C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114718 mRNA. Translation: AAI14719.1.
RefSeqiXP_010796495.1. XM_010798193.2.
XP_010814094.1. XM_010815792.2.
UniGeneiBt.7155.

Genome annotation databases

EnsembliENSBTAT00000026285; ENSBTAP00000026285; ENSBTAG00000019723.
GeneIDi506007.
KEGGibta:506007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114718 mRNA. Translation: AAI14719.1.
RefSeqiXP_010796495.1. XM_010798193.2.
XP_010814094.1. XM_010815792.2.
UniGeneiBt.7155.

3D structure databases

ProteinModelPortaliA4FUD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026285.

Proteomic databases

PaxDbiA4FUD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026285; ENSBTAP00000026285; ENSBTAG00000019723.
GeneIDi506007.
KEGGibta:506007.

Organism-specific databases

CTDi5193.

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiA4FUD4.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG091G0BN4.
TreeFamiTF314511.

Gene expression databases

BgeeiENSBTAG00000019723.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEX12_BOVIN
AccessioniPrimary (citable) accession number: A4FUD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.