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Protein

GPN-loop GTPase 1

Gene

GPN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Stabilizes the phosphate intermediate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 346GTPBy similarity
Nucleotide bindingi189 – 1924GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase 1By similarity (EC:3.6.5.-By similarity)
Alternative name(s):
XPA-binding protein 1By similarity
Gene namesi
Name:GPN1By similarity
Synonyms:XAB1By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 373372GPN-loop GTPase 1PRO_0000330934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity
Modified residuei312 – 3121PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei328 – 3281PhosphothreonineBy similarity
Modified residuei338 – 3381PhosphoserineBy similarity
Modified residuei340 – 3401PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4FUD1.
PRIDEiA4FUD1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003904.

Interactioni

Subunit structurei

Heterodimer with GPN3. Binds to RNA polymerase II (RNAPII). Interacts directly with RNAPII subunits RPB4 and RPB7 and the CTD of RPB1. Interacts with XPA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005098.

Structurei

3D structure databases

ProteinModelPortaliA4FUD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi86 – 883Gly-Pro-Asn (GPN)-loop; involved in dimer interfaceBy similarity

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiKOG1532. Eukaryota.
ENOG410XNRC. LUCA.
GeneTreeiENSGT00550000074926.
HOGENOMiHOG000191633.
HOVERGENiHBG047768.
InParanoidiA4FUD1.
KOiK06883.
OMAiKPVCLIV.
OrthoDBiEOG091G0EA4.
TreeFamiTF313204.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004130. Gpn.
IPR030230. Gpn1/Npa3/XAB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR21231. PTHR21231. 1 hit.
PTHR21231:SF8. PTHR21231:SF8. 1 hit.
PfamiPF03029. ATP_bind_1. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FUD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPASATES QASGGPRPPA CLLVLGMAGS GKTTFVQRLT GYLHSQGCPP
60 70 80 90 100
YVINLDPAVH EVPFPANIDI RDTVKYKEVM KQYGLGPNGG IVTSLNLFAT
110 120 130 140 150
RFDQVMKFIE KAQNMSKYVL IDTPGQIEVF TWSASGTIIT EALASSFPTI
160 170 180 190 200
VIYVMDTSRS TNPVTFMSNM LYACSILYKT KLPFIVVMNK TDIIDHSFAV
210 220 230 240 250
EWMQDFEAFQ DALNQETTYV SNLTRSMSLV LDEFYSSLRV VGVSAVLGTG
260 270 280 290 300
LDELFVQVAS ATEEYEREYR PEYERLKKSL ASAQSQQQKE QLERLQKDMG
310 320 330 340 350
SVALDTGTAT GSSSPVLDPS DLILTRGTLD EEDEEADSDT DDIDHRVTEE
360 370
SREEPAFQNF MQESMAQYWK KNK
Length:373
Mass (Da):41,450
Last modified:April 17, 2007 - v1
Checksum:i4FA0B8B9FB696A84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114712 mRNA. Translation: AAI14713.1.
RefSeqiNP_001076861.1. NM_001083392.1.
UniGeneiBt.13501.

Genome annotation databases

EnsembliENSBTAT00000005098; ENSBTAP00000005098; ENSBTAG00000003904.
GeneIDi508522.
KEGGibta:508522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114712 mRNA. Translation: AAI14713.1.
RefSeqiNP_001076861.1. NM_001083392.1.
UniGeneiBt.13501.

3D structure databases

ProteinModelPortaliA4FUD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005098.

Proteomic databases

PaxDbiA4FUD1.
PRIDEiA4FUD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005098; ENSBTAP00000005098; ENSBTAG00000003904.
GeneIDi508522.
KEGGibta:508522.

Organism-specific databases

CTDi11321.

Phylogenomic databases

eggNOGiKOG1532. Eukaryota.
ENOG410XNRC. LUCA.
GeneTreeiENSGT00550000074926.
HOGENOMiHOG000191633.
HOVERGENiHBG047768.
InParanoidiA4FUD1.
KOiK06883.
OMAiKPVCLIV.
OrthoDBiEOG091G0EA4.
TreeFamiTF313204.

Gene expression databases

BgeeiENSBTAG00000003904.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004130. Gpn.
IPR030230. Gpn1/Npa3/XAB1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR21231. PTHR21231. 1 hit.
PTHR21231:SF8. PTHR21231:SF8. 1 hit.
PfamiPF03029. ATP_bind_1. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPN1_BOVIN
AccessioniPrimary (citable) accession number: A4FUD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.