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Protein

GPN-loop GTPase 1

Gene

GPN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Stabilizes the phosphate intermediate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 34GTPBy similarity6
Nucleotide bindingi189 – 192GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase 1By similarity (EC:3.6.5.-By similarity)
Alternative name(s):
XPA-binding protein 1By similarity
Gene namesi
Name:GPN1By similarity
Synonyms:XAB1By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:29538 GPN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003309342 – 373GPN-loop GTPase 1Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei328PhosphothreonineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Modified residuei340PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4FUD1
PRIDEiA4FUD1

Expressioni

Gene expression databases

BgeeiENSBTAG00000003904

Interactioni

Subunit structurei

Heterodimer with GPN3. Binds to RNA polymerase II (RNAPII). Interacts directly with RNAPII subunits RPB4 and RPB7 and the CTD of RPB1. Interacts with XPA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005098

Structurei

3D structure databases

ProteinModelPortaliA4FUD1
SMRiA4FUD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi86 – 88Gly-Pro-Asn (GPN)-loop; involved in dimer interfaceBy similarity3

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiKOG1532 Eukaryota
ENOG410XNRC LUCA
GeneTreeiENSGT00550000074926
HOGENOMiHOG000191633
HOVERGENiHBG047768
InParanoidiA4FUD1
KOiK06883
OMAiESMAQYW
OrthoDBiEOG091G0EA4
TreeFamiTF313204

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004130 Gpn
IPR030230 Gpn1/Npa3/XAB1
IPR027417 P-loop_NTPase
PANTHERiPTHR21231 PTHR21231, 1 hit
PTHR21231:SF12 PTHR21231:SF12, 1 hit
PfamiView protein in Pfam
PF03029 ATP_bind_1, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FUD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPASATES QASGGPRPPA CLLVLGMAGS GKTTFVQRLT GYLHSQGCPP
60 70 80 90 100
YVINLDPAVH EVPFPANIDI RDTVKYKEVM KQYGLGPNGG IVTSLNLFAT
110 120 130 140 150
RFDQVMKFIE KAQNMSKYVL IDTPGQIEVF TWSASGTIIT EALASSFPTI
160 170 180 190 200
VIYVMDTSRS TNPVTFMSNM LYACSILYKT KLPFIVVMNK TDIIDHSFAV
210 220 230 240 250
EWMQDFEAFQ DALNQETTYV SNLTRSMSLV LDEFYSSLRV VGVSAVLGTG
260 270 280 290 300
LDELFVQVAS ATEEYEREYR PEYERLKKSL ASAQSQQQKE QLERLQKDMG
310 320 330 340 350
SVALDTGTAT GSSSPVLDPS DLILTRGTLD EEDEEADSDT DDIDHRVTEE
360 370
SREEPAFQNF MQESMAQYWK KNK
Length:373
Mass (Da):41,450
Last modified:April 17, 2007 - v1
Checksum:i4FA0B8B9FB696A84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114712 mRNA Translation: AAI14713.1
RefSeqiNP_001076861.1, NM_001083392.1
UniGeneiBt.13501

Genome annotation databases

EnsembliENSBTAT00000005098; ENSBTAP00000005098; ENSBTAG00000003904
GeneIDi508522
KEGGibta:508522

Similar proteinsi

Entry informationi

Entry nameiGPN1_BOVIN
AccessioniPrimary (citable) accession number: A4FUD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health