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Protein

F-actin-capping protein subunit alpha-1

Gene

CAPZA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-BTA-2132295. MHC class II antigen presentation.
R-BTA-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-BTA-879415. Advanced glycosylation endproduct receptor signaling.
R-BTA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-1
Alternative name(s):
CapZ alpha-1
Gene namesi
Name:CAPZA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003555632 – 286F-actin-capping protein subunit alpha-1Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4FUA8.
PeptideAtlasiA4FUA8.
PRIDEiA4FUA8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014295.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with S100B and S100A. Interacts with SH3BP1; recruits CAPZA1 to forming cell junctions. Interacts with CD2AP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiA4FUA8.
STRINGi9913.ENSBTAP00000042551.

Structurei

3D structure databases

ProteinModelPortaliA4FUA8.
SMRiA4FUA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiA4FUA8.
KOiK10364.
OMAiACDSALR.
OrthoDBiEOG091G0KST.
TreeFamiTF314822.

Family and domain databases

InterProiView protein in InterPro
IPR002189. CapZ_alpha.
IPR037282. CapZ_alpha/beta.
IPR017865. F-actin_cap_asu_CS.
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiView protein in Pfam
PF01267. F-actin_cap_A. 1 hit.
PRINTSiPR00191. FACTINCAPA.
SUPFAMiSSF90096. SSF90096. 1 hit.
PROSITEiView protein in PROSITE
PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4FUA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA
60 70 80 90 100
AHAFAQYNMD QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH
110 120 130 140 150
LRKEASDPQP EEADGGLKSW RESCDSALRA YVKDHYSNGF CTVYAKTIDG
160 170 180 190 200
QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPTAQVVG VLKIQVHYYE
210 220 230 240 250
DGNVQLVSHK DVQDSVTVSN EAQTAKEFIK IIEHAENEYQ TAISENYQTM
260 270 280
SDTTFKALRR QLPVTRTKVD WNKILSYKIG KEMQNA
Length:286
Mass (Da):32,932
Last modified:April 17, 2007 - v1
Checksum:i4E4D6EDD7BA0FC4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030727 mRNA. Translation: ABS45043.1.
BC114648 mRNA. Translation: AAI14649.1.
RefSeqiNP_001076949.1. NM_001083480.2.
UniGeneiBt.45960.

Genome annotation databases

EnsembliENSBTAT00000045136; ENSBTAP00000042551; ENSBTAG00000014295.
GeneIDi534656.
KEGGibta:534656.

Similar proteinsi

Entry informationi

Entry nameiCAZA1_BOVIN
AccessioniPrimary (citable) accession number: A4FUA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 17, 2007
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families