ID   A4FU51_HUMAN            Unreviewed;       864 AA.
AC   A4FU51;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   SubName: Full=NMDA receptor regulated 1-like {ECO:0000313|EMBL:AAI01720.1, ECO:0000313|EMBL:EAX08656.1};
DE   SubName: Full=cDNA FLJ77538, highly similar to Homo sapiens NMDA receptor regulated 1-like (NARG1L), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF83937.1};
GN   Name=NARG1L {ECO:0000313|EMBL:AAI01720.1};
GN   ORFNames=hCG_2020106 {ECO:0000313|EMBL:EAX08656.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI01720.1};
RN   [1] {ECO:0000313|EMBL:EAX08656.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
RA   Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
RA   Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
RA   Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
RA   McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
RA   Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
RA   Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
RA   Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
RA   Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
RA   Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
RA   Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
RA   Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
RA   Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
RA   Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
RA   Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
RA   Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
RA   Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
RA   Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
RA   Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
RA   Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
RA   Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
RA   Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
RA   McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
RA   Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
RA   Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
RA   Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
RA   Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
RA   Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
RA   Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
RA   Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
RA   Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
RA   Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
RA   Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
RA   Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
RA   Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
RA   Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
RA   Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:AAI01720.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:AAI01720.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000313|EMBL:EAX08656.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:BAF83937.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC101719; AAI01720.1; -; mRNA.
DR   EMBL; BC101721; AAI01722.1; -; mRNA.
DR   EMBL; AK291248; BAF83937.1; -; mRNA.
DR   EMBL; CH471075; EAX08656.1; -; Genomic_DNA.
DR   RefSeq; NP_078837.3; NM_024561.4.
DR   AlphaFoldDB; A4FU51; -.
DR   SMR; A4FU51; -.
DR   Antibodypedia; 23410; 78 antibodies from 19 providers.
DR   DNASU; 79612; -.
DR   GeneID; 79612; -.
DR   KEGG; hsa:79612; -.
DR   CTD; 79612; -.
DR   PharmGKB; PA165505266; -.
DR   VEuPathDB; HostDB:ENSG00000172766; -.
DR   HOGENOM; CLU_006686_0_0_1; -.
DR   OMA; IYEESWV; -.
DR   OrthoDB; 23236at2759; -.
DR   BioGRID-ORCS; 79612; 25 hits in 1153 CRISPR screens.
DR   ChiTaRS; NAA16; human.
DR   GenomeRNAi; 79612; -.
DR   ExpressionAtlas; A4FU51; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   Gene3D; 1.25.40.1010; -; 1.
DR   Gene3D; 1.25.40.1040; -; 1.
DR   InterPro; IPR021183; NatA_aux_su.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR22767:SF5; N-ALPHA-ACETYLTRANSFERASE 16, NATA AUXILIARY SUBUNIT; 1.
DR   PANTHER; PTHR22767; N-TERMINAL ACETYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF12569; NatA_aux_su; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   PIRSF; PIRSF000422; N-terminal-AcTrfase-A_aux_su; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   2: Evidence at transcript level;
KW   Receptor {ECO:0000313|EMBL:AAI01720.1};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          80..113
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          603..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  101462 MW;  510001EC0D9DD592 CRC64;
     MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG
     KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL
     SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV
     PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL
     KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL
     VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS
     PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH
     IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN
     EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD
     LLRLEDILRR HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR
     RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV ENPLEEAVKF
     LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA INSNNPWLHE CLIRFSKSVS
     NHSNLPDIVS KVLSQEMQKI FVKKDLESFN EDFLKRNATS LQHLLSGAKM MYFLDKSRQE
     KAIAIATRLD ETIKDKDVKT LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA
     VNEVDNPNVA LNHTANYDVL ANEI
//