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Protein

SH3 domain-containing protein 21

Gene

SH3D21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing protein 21
Gene namesi
Name:SH3D21
Synonyms:C1orf113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26236. SH3D21.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640SH3 domain-containing protein 21PRO_0000337129Add
BLAST

Proteomic databases

MaxQBiA4FU49.
PaxDbiA4FU49.
PRIDEiA4FU49.

PTM databases

PhosphoSiteiA4FU49.

Expressioni

Gene expression databases

BgeeiA4FU49.
CleanExiHS_C1orf113.
ExpressionAtlasiA4FU49. baseline and differential.
GenevestigatoriA4FU49.

Organism-specific databases

HPAiHPA042212.
HPA042456.

Interactioni

Protein-protein interaction databases

IntActiA4FU49. 1 interaction.
STRINGi9606.ENSP00000321936.

Structurei

3D structure databases

ProteinModelPortaliA4FU49.
SMRiA4FU49. Positions 71-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 12662SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili572 – 62655Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 1264Poly-Pro

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG119357.
GeneTreeiENSGT00530000063594.
HOVERGENiHBG107554.
InParanoidiA4FU49.
OMAiFAQKTRP.
OrthoDBiEOG7P8P7T.
PhylomeDBiA4FU49.
TreeFamiTF351294.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4FU49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQSELQLQP RAGGRAEAAS WGDRGNDKGG LGNPDMPSVS PGPQRPPKLS
60 70 80 90 100
SLAYDSPPDY LQTVSHPEVY RVLFDYQPEA PDELALRRGD VVKVLSKTTE
110 120 130 140 150
DKGWWEGECQ GRRGVFPDNF VLPPPPIKKL VPRKVVSRES APIKEPKKLM
160 170 180 190 200
PKTSLPTVKK LATATTGPSK AKTSRTPSRD SQKLTSRDSG PNGGFQSGGS
210 220 230 240 250
YHPGRKRSKT QTPQQRSVSS QEEEHSSPVK APSVKRTPMP DKTATPERPP
260 270 280 290 300
APENAPSSKK IPAPDKVPSP EKTLTLGDKA SIPGNSTSGK IPAPDKVPTP
310 320 330 340 350
EKMVTPEDKA SIPENSIIPE ETLTVDKPST PERVFSVEES PALEAPPMDK
360 370 380 390 400
VPNPKMAPLG DEAPTLEKVL TPELSEEEVS TRDDIQFHHF SSEEALQKVK
410 420 430 440 450
YFVAKEDPSS QEEAHTPEAP PPQPPSSERC LGEMKCTLVR GDSSPRQAEL
460 470 480 490 500
KSGPASRPAL EKPHPHEEAT TLPEEAPSND ERTPEEEAPP NEQRPLREEV
510 520 530 540 550
LPKEGVASKE EVTLKEELPP KEEVAPKEEV PPIERAFAQK TRPIKPPPDS
560 570 580 590 600
QETLALPSLV PQNYTENKNE GVDVTSLRGE VESLRRALEL MEVQLERKLT
610 620 630 640
DIWEELKSEK EQRRRLEVQV MQGTQKSQTP RVIHTQTQTY

Note: No experimental confirmation available. Gene prediction based on EST data and similarity to mouse and macaca fascicularis orthologs.

Length:640
Mass (Da):70,519
Last modified:May 19, 2008 - v2
Checksum:i59992262EE553FA3
GO
Isoform 2 (identifier: A4FU49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MVQSELQLQPRAGGRAEAASWGDRGNDKGG → MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS

Note: No experimental confirmation available.

Show »
Length:645
Mass (Da):71,238
Checksum:iD7FA6E6957E2036C
GO
Isoform 3 (identifier: A4FU49-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MVQSELQLQP...RRGDVVKVLS → MIKEIEDGWW...SVSPGPQRPP
     173-179: TSRTPSR → RKSTAAR
     180-640: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:135
Mass (Da):14,779
Checksum:i4790D889DFD47599
GO
Isoform 4 (identifier: A4FU49-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-232: PNGGFQSGGS...EEHSSPVKAP → GRAQQPGKGP...RPQLQEDPGS
     233-640: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:232
Mass (Da):25,313
Checksum:i0DA164A88407EF27
GO
Isoform 5 (identifier: A4FU49-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MVQSELQLQPRAGGRAEAASWGDRGNDKGG → MEVLVLAGYR...VELLDSGPPS

Show »
Length:756
Mass (Da):83,970
Checksum:i1B6BA2463B701102
GO

Sequence cautioni

The sequence BAB15504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH71860.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAX07375.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAX07376.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti327 – 3271K → E in BAB71191 (PubMed:14702039).Curated
Sequence conflicti413 – 4131E → G in BAB71191 (PubMed:14702039).Curated
Sequence conflicti541 – 5422TR → NS in BAB71191 (PubMed:14702039).Curated
Sequence conflicti582 – 5821E → G in BAB71191 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171S → A.
Corresponds to variant rs12121759 [ dbSNP | Ensembl ].
VAR_043619
Natural varianti455 – 4551A → S.
Corresponds to variant rs12121759 [ dbSNP | Ensembl ].
VAR_056763

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9696MVQSE…VKVLS → MIKEIEDGWWLGKRNGQLGA FPSNFVELLDSGPPSLGNPD MPSVSPGPQRPP in isoform 3. 2 PublicationsVSP_040923Add
BLAST
Alternative sequencei1 – 3030MVQSE…NDKGG → MIKEIEDGWWLGKKNGQLGA FPSNFVELLDSGPPS in isoform 2. 2 PublicationsVSP_040924Add
BLAST
Alternative sequencei1 – 3030MVQSE…NDKGG → MEVLVLAGYRAQKEDELSLA PGDVVRQVRWVPARGWLRGE FGGRYGLFPERLVQEIPETL RGSGEARRPRCARRRGHPAK HPRPQRWCKVNFSYSPEQAD ELKLQAGEIVEMIKEIEDGW WLGKKNGQLGAFPSNFVELL DSGPPS in isoform 5. CuratedVSP_045936Add
BLAST
Alternative sequencei173 – 1797TSRTPSR → RKSTAAR in isoform 3. 2 PublicationsVSP_040925
Alternative sequencei180 – 640461Missing in isoform 3. 2 PublicationsVSP_040926Add
BLAST
Alternative sequencei191 – 23242PNGGF…PVKAP → GRAQQPGKGPLCEENPHAGQ DCHPREAPSSRERPQLQEDP GS in isoform 4. 1 PublicationVSP_040927Add
BLAST
Alternative sequencei233 – 640408Missing in isoform 4. 1 PublicationVSP_040928Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026591 mRNA. Translation: BAB15504.1. Different initiation.
AK297015 mRNA. Translation: BAG59548.1.
AK056459 mRNA. Translation: BAB71191.1. Sequence problems.
AL591845 Genomic DNA. Translation: CAH71860.2. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07374.1.
CH471059 Genomic DNA. Translation: EAX07375.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07376.1. Sequence problems.
BC036763 mRNA. Translation: AAH36763.1.
BC048273 mRNA. Translation: AAH48273.1.
BC101676 mRNA. Translation: AAI01677.1. Sequence problems.
BC101678 mRNA. Translation: AAI01679.1. Sequence problems.
CCDSiCCDS30674.2. [A4FU49-3]
RefSeqiNP_001156002.1. NM_001162530.1. [A4FU49-6]
NP_078952.4. NM_024676.4. [A4FU49-3]
UniGeneiHs.524496.

Genome annotation databases

EnsembliENST00000453908; ENSP00000403476; ENSG00000214193. [A4FU49-6]
ENST00000505871; ENSP00000421294; ENSG00000214193. [A4FU49-3]
GeneIDi79729.
KEGGihsa:79729.
UCSCiuc009vuz.1. human. [A4FU49-1]
uc010oia.1. human.
uc010oib.1. human. [A4FU49-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026591 mRNA. Translation: BAB15504.1. Different initiation.
AK297015 mRNA. Translation: BAG59548.1.
AK056459 mRNA. Translation: BAB71191.1. Sequence problems.
AL591845 Genomic DNA. Translation: CAH71860.2. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07374.1.
CH471059 Genomic DNA. Translation: EAX07375.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07376.1. Sequence problems.
BC036763 mRNA. Translation: AAH36763.1.
BC048273 mRNA. Translation: AAH48273.1.
BC101676 mRNA. Translation: AAI01677.1. Sequence problems.
BC101678 mRNA. Translation: AAI01679.1. Sequence problems.
CCDSiCCDS30674.2. [A4FU49-3]
RefSeqiNP_001156002.1. NM_001162530.1. [A4FU49-6]
NP_078952.4. NM_024676.4. [A4FU49-3]
UniGeneiHs.524496.

3D structure databases

ProteinModelPortaliA4FU49.
SMRiA4FU49. Positions 71-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4FU49. 1 interaction.
STRINGi9606.ENSP00000321936.

PTM databases

PhosphoSiteiA4FU49.

Proteomic databases

MaxQBiA4FU49.
PaxDbiA4FU49.
PRIDEiA4FU49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453908; ENSP00000403476; ENSG00000214193. [A4FU49-6]
ENST00000505871; ENSP00000421294; ENSG00000214193. [A4FU49-3]
GeneIDi79729.
KEGGihsa:79729.
UCSCiuc009vuz.1. human. [A4FU49-1]
uc010oia.1. human.
uc010oib.1. human. [A4FU49-3]

Organism-specific databases

CTDi79729.
GeneCardsiGC01P036772.
H-InvDBHIX0199850.
HGNCiHGNC:26236. SH3D21.
HPAiHPA042212.
HPA042456.
neXtProtiNX_A4FU49.
PharmGKBiPA142672497.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119357.
GeneTreeiENSGT00530000063594.
HOVERGENiHBG107554.
InParanoidiA4FU49.
OMAiFAQKTRP.
OrthoDBiEOG7P8P7T.
PhylomeDBiA4FU49.
TreeFamiTF351294.

Miscellaneous databases

ChiTaRSiSH3D21. human.
GenomeRNAii79729.
NextBioi35535373.
PROiA4FU49.

Gene expression databases

BgeeiA4FU49.
CleanExiHS_C1orf113.
ExpressionAtlasiA4FU49. baseline and differential.
GenevestigatoriA4FU49.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Signet-ring cell carcinoma, Teratocarcinoma and Umbilical cord blood.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-640 (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-640 (ISOFORM 2).
    Tissue: Brain, Liver and Ovary.

Entry informationi

Entry nameiSH321_HUMAN
AccessioniPrimary (citable) accession number: A4FU49
Secondary accession number(s): B4DLI6
, D3DPS6, J3KQM5, Q5VTK7, Q86XZ6, Q8N445, Q96DN4, Q9H5W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: May 19, 2008
Last modified: January 6, 2015
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.