ID MTMRB_HUMAN Reviewed; 709 AA. AC A4FU01; B3KUE4; B4DJI6; B4DQF5; B4E3Q6; Q3ZCP7; Q5SZ62; Q6P2Q8; Q99752; AC Q99753; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 24-JAN-2024, entry version 123. DE RecName: Full=Myotubularin-related protein 11; DE AltName: Full=Cisplatin resistance-associated protein; DE Short=hCRA; DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 11 {ECO:0000305}; GN Name=MTMR11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5). RC TISSUE=Ovary tumor, Small intestine, Thalamus, and Uterus; RA Tanimura H., Ledakis P., Fojo T.; RL Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 6). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 31-709 (ISOFORM 1), AND VARIANT VAL-159. RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP TISSUE SPECIFICITY. RX PubMed=17498563; DOI=10.1016/j.cancergencyto.2007.01.011; RA La Starza R., Crescenzi B., Pierini V., Romoli S., Gorello P., RA Brandimarte L., Matteucci C., Kropp M.G., Barba G., Martelli M.F., RA Mecucci C.; RT "A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic RT leukemia and Burkitt lymphoma."; RL Cancer Genet. Cytogenet. 175:73-76(2007). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; CC IsoId=A4FU01-1; Sequence=Displayed; CC Name=2; Synonyms=hCRA alpha; CC IsoId=A4FU01-2; Sequence=VSP_033887, VSP_033888; CC Name=3; CC IsoId=A4FU01-3; Sequence=VSP_033884, VSP_033887, VSP_033888; CC Name=4; CC IsoId=A4FU01-4; Sequence=VSP_033883, VSP_033885, VSP_033890; CC Name=5; Synonyms=hCRA beta; CC IsoId=A4FU01-5; Sequence=VSP_033886, VSP_033889; CC Name=6; CC IsoId=A4FU01-6; Sequence=VSP_033884, VSP_035725, VSP_035726; CC -!- TISSUE SPECIFICITY: Expressed in bone marrow, spleen and thymus. CC {ECO:0000269|PubMed:17498563}. CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA CC decay. {ECO:0000305}. CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA CC decay. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non- CC receptor class myotubularin subfamily. {ECO:0000305}. CC -!- CAUTION: Although it belongs to the non-receptor class myotubularin CC subfamily, lacks the conserved active site cysteine residue at position CC 375 in the dsPTPase catalytic loop, suggesting that it has no CC phosphatase activity. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAB36952.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAB36953.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAH94756.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U78556; AAB36952.1; ALT_FRAME; mRNA. DR EMBL; U78557; AAB36953.1; ALT_FRAME; mRNA. DR EMBL; AK097000; BAG53406.1; -; mRNA. DR EMBL; AK296094; BAG58848.1; -; mRNA. DR EMBL; AK298775; BAG60917.1; -; mRNA. DR EMBL; AK304820; BAG65568.1; -; mRNA. DR EMBL; AL590487; CAI12649.1; -; Genomic_DNA. DR EMBL; CH471121; EAW53589.1; -; Genomic_DNA. DR EMBL; CH471121; EAW53590.1; -; Genomic_DNA. DR EMBL; CH471121; EAW53594.1; -; Genomic_DNA. DR EMBL; BC064372; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC094756; AAH94756.1; ALT_INIT; mRNA. DR EMBL; BC100818; AAI00819.1; -; mRNA. DR EMBL; BC100819; AAI00820.1; -; mRNA. DR EMBL; BC100820; AAI00821.1; -; mRNA. DR CCDS; CCDS72901.1; -. [A4FU01-4] DR CCDS; CCDS72902.1; -. [A4FU01-1] DR RefSeq; NP_001139334.1; NM_001145862.1. [A4FU01-1] DR RefSeq; NP_870988.2; NM_181873.3. [A4FU01-4] DR AlphaFoldDB; A4FU01; -. DR SMR; A4FU01; -. DR BioGRID; 116109; 20. DR IntAct; A4FU01; 17. DR MINT; A4FU01; -. DR STRING; 9606.ENSP00000391668; -. DR DEPOD; MTMR11; -. DR iPTMnet; A4FU01; -. DR PhosphoSitePlus; A4FU01; -. DR BioMuta; MTMR11; -. DR EPD; A4FU01; -. DR jPOST; A4FU01; -. DR MassIVE; A4FU01; -. DR MaxQB; A4FU01; -. DR PaxDb; 9606-ENSP00000391668; -. DR PeptideAtlas; A4FU01; -. DR ProteomicsDB; 656; -. [A4FU01-1] DR ProteomicsDB; 657; -. [A4FU01-2] DR ProteomicsDB; 658; -. [A4FU01-3] DR ProteomicsDB; 659; -. [A4FU01-4] DR ProteomicsDB; 660; -. [A4FU01-5] DR ProteomicsDB; 661; -. [A4FU01-6] DR Antibodypedia; 34015; 62 antibodies from 13 providers. DR DNASU; 10903; -. DR Ensembl; ENST00000369140.7; ENSP00000358136.3; ENSG00000014914.21. [A4FU01-4] DR Ensembl; ENST00000439741.4; ENSP00000391668.2; ENSG00000014914.21. [A4FU01-1] DR GeneID; 10903; -. DR KEGG; hsa:10903; -. DR MANE-Select; ENST00000439741.4; ENSP00000391668.2; NM_001145862.2; NP_001139334.1. DR UCSC; uc001etl.5; human. [A4FU01-1] DR AGR; HGNC:24307; -. DR CTD; 10903; -. DR DisGeNET; 10903; -. DR GeneCards; MTMR11; -. DR HGNC; HGNC:24307; MTMR11. DR HPA; ENSG00000014914; Tissue enhanced (intestine). DR neXtProt; NX_A4FU01; -. DR OpenTargets; ENSG00000014914; -. DR PharmGKB; PA142671303; -. DR VEuPathDB; HostDB:ENSG00000014914; -. DR eggNOG; KOG1089; Eukaryota. DR GeneTree; ENSGT00940000160276; -. DR HOGENOM; CLU_021912_1_0_1; -. DR InParanoid; A4FU01; -. DR OMA; GWQRSQD; -. DR OrthoDB; 5474662at2759; -. DR PhylomeDB; A4FU01; -. DR TreeFam; TF315197; -. DR PathwayCommons; A4FU01; -. DR SignaLink; A4FU01; -. DR BioGRID-ORCS; 10903; 15 hits in 1161 CRISPR screens. DR ChiTaRS; MTMR11; human. DR GenomeRNAi; 10903; -. DR Pharos; A4FU01; Tdark. DR PRO; PR:A4FU01; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; A4FU01; Protein. DR Bgee; ENSG00000014914; Expressed in mucosa of transverse colon and 133 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR InterPro; IPR022587; MTMR12-like_C. DR InterPro; IPR010569; Myotubularin-like_Pase_dom. DR InterPro; IPR030564; Myotubularin_fam. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1. DR PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1. DR Pfam; PF12578; 3-PAP; 1. DR Pfam; PF06602; Myotub-related; 2. DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1. DR Genevisible; A4FU01; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Reference proteome. FT CHAIN 1..709 FT /note="Myotubularin-related protein 11" FT /id="PRO_0000337098" FT DOMAIN 196..639 FT /note="Myotubularin phosphatase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00669" FT REGION 1..39 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..72 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_033883" FT VAR_SEQ 1..28 FT /note="Missing (in isoform 3 and isoform 6)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_033884" FT VAR_SEQ 73..75 FT /note="TNF -> MPP (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_033885" FT VAR_SEQ 228..272 FT /note="SLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRC -> RLR FT CFSSSLIVSGSSSSSFQLILNSLSFSFLLFMTVSGFLTPLPS (in isoform 5)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_033886" FT VAR_SEQ 258..268 FT /note="RLSWHHPGGSD -> VSVMVRVMAVD (in isoform 2 and isoform FT 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1" FT /id="VSP_033887" FT VAR_SEQ 269..709 FT /note="Missing (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1" FT /id="VSP_033888" FT VAR_SEQ 273..709 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_033889" FT VAR_SEQ 375..382 FT /note="ERGDRDLN -> GSGVSPLP (in isoform 6)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_035725" FT VAR_SEQ 383..709 FT /note="Missing (in isoform 6)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_035726" FT VAR_SEQ 703..709 FT /note="RAEGDLG -> QSHPFWITRC (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_033890" FT VARIANT 159 FT /note="M -> V (in dbSNP:rs11205303)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_043598" FT VARIANT 531 FT /note="Q -> P (in dbSNP:rs16836857)" FT /id="VAR_043599" FT CONFLICT 86 FT /note="W -> R (in Ref. 2; BAG60917)" FT /evidence="ECO:0000305" FT CONFLICT 165 FT /note="R -> G (in Ref. 2; BAG60917)" FT /evidence="ECO:0000305" FT CONFLICT 263 FT /note="H -> R (in Ref. 2; BAG53406)" FT /evidence="ECO:0000305" SQ SEQUENCE 709 AA; 79545 MW; AC07581E26364D1F CRC64; MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ ILAWAPGVRK GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL VNIGRLEAVS GLSRVQLLRP GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL EPQAFQVTMA IVQARAQSNQ AQQYSGITLS KAGQGSGSRK PPIPLMETAE DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL DSEVRRAFGH FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV RACLRKASDI SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL FGFQSLVQRE WVAAGHPFLT RLGGTGASEE APVFLLFLDC VWQLLQQFPA DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW ERGKQSGQLN SYTQVYTPGY SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC PDSWLPRPQP SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL SAPTISGLQD ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL KGRAEGDLG //