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A4FU01 (MTMRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 11
Alternative name(s):
Cisplatin resistance-associated protein
Short name=hCRA
Gene names
Name:MTMR11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.

Tissue specificity

Expressed in bone marrow, spleen and thymus. Ref.6

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 myotubularin phosphatase domain.

Sequence caution

The sequence AAB36952.1 differs from that shown. Reason: Frameshift at position 8.

The sequence AAB36953.1 differs from that shown. Reason: Frameshift at position 8.

The sequence AAH94756.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A4FU01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A4FU01-2)

Also known as: hCRA alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: A4FU01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: A4FU01-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-75: TNF → MPP
     703-709: RAEGDLG → QSHPFWITRC
Isoform 5 (identifier: A4FU01-5)

Also known as: hCRA beta;

The sequence of this isoform differs from the canonical sequence as follows:
     228-272: SLPRYFWVPN...HPGGSDLLRC → RLRCFSSSLI...VSGFLTPLPS
     273-709: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: A4FU01-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     375-382: ERGDRDLN → GSGVSPLP
     383-709: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Myotubularin-related protein 11
PRO_0000337098

Regions

Domain196 – 639444Myotubularin phosphatase

Natural variations

Alternative sequence1 – 7272Missing in isoform 4.
VSP_033883
Alternative sequence1 – 2828Missing in isoform 3 and isoform 6.
VSP_033884
Alternative sequence73 – 753TNF → MPP in isoform 4.
VSP_033885
Alternative sequence228 – 27245SLPRY…DLLRC → RLRCFSSSLIVSGSSSSSFQ LILNSLSFSFLLFMTVSGFL TPLPS in isoform 5.
VSP_033886
Alternative sequence258 – 26811RLSWHHPGGSD → VSVMVRVMAVD in isoform 2 and isoform 3.
VSP_033887
Alternative sequence269 – 709441Missing in isoform 2 and isoform 3.
VSP_033888
Alternative sequence273 – 709437Missing in isoform 5.
VSP_033889
Alternative sequence375 – 3828ERGDRDLN → GSGVSPLP in isoform 6.
VSP_035725
Alternative sequence383 – 709327Missing in isoform 6.
VSP_035726
Alternative sequence703 – 7097RAEGDLG → QSHPFWITRC in isoform 4.
VSP_033890
Natural variant1591M → V. Ref.5
Corresponds to variant rs11205303 [ dbSNP | Ensembl ].
VAR_043598
Natural variant5311Q → P.
Corresponds to variant rs16836857 [ dbSNP | Ensembl ].
VAR_043599

Experimental info

Sequence conflict861W → R in BAG60917. Ref.2
Sequence conflict1651R → G in BAG60917. Ref.2
Sequence conflict2631H → R in BAG53406. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: AC07581E26364D1F

FASTA70979,545
        10         20         30         40         50         60 
MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ ILAWAPGVRK 

        70         80         90        100        110        120 
GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL VNIGRLEAVS GLSRVQLLRP 

       130        140        150        160        170        180 
GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL EPQAFQVTMA IVQARAQSNQ AQQYSGITLS 

       190        200        210        220        230        240 
KAGQGSGSRK PPIPLMETAE DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL 

       250        260        270        280        290        300 
DSEVRRAFGH FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV 

       310        320        330        340        350        360 
VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV RACLRKASDI 

       370        380        390        400        410        420 
SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL FGFQSLVQRE WVAAGHPFLT 

       430        440        450        460        470        480 
RLGGTGASEE APVFLLFLDC VWQLLQQFPA DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW 

       490        500        510        520        530        540 
ERGKQSGQLN SYTQVYTPGY SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC 

       550        560        570        580        590        600 
PDSWLPRPQP SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE 

       610        620        630        640        650        660 
SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL SAPTISGLQD 

       670        680        690        700 
ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL KGRAEGDLG 

« Hide

Isoform 2 (hCRA alpha) [UniParc].

Checksum: 3767F7815C94AAE0
Show »

FASTA26830,116
Isoform 3 [UniParc].

Checksum: E8D6FA7FD8657504
Show »

FASTA24026,885
Isoform 4 [UniParc].

Checksum: DB67312F79750231
Show »

FASTA64072,117
Isoform 5 (hCRA beta) [UniParc].

Checksum: 24FE481676EF146D
Show »

FASTA27230,195
Isoform 6 [UniParc].

Checksum: 2032989C2E856CAA
Show »

FASTA35439,372

References

« Hide 'large scale' references
[1]Tanimura H., Ledakis P., Fojo T.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5).
Tissue: Ovary tumor, Small intestine, Thalamus and Uterus.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 6).
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-709 (ISOFORM 1), VARIANT VAL-159.
Tissue: Ovary.
[6]"A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma."
La Starza R., Crescenzi B., Pierini V., Romoli S., Gorello P., Brandimarte L., Matteucci C., Kropp M.G., Barba G., Martelli M.F., Mecucci C.
Cancer Genet. Cytogenet. 175:73-76(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78556 mRNA. Translation: AAB36952.1. Frameshift.
U78557 mRNA. Translation: AAB36953.1. Frameshift.
AK097000 mRNA. Translation: BAG53406.1.
AK296094 mRNA. Translation: BAG58848.1.
AK298775 mRNA. Translation: BAG60917.1.
AK304820 mRNA. Translation: BAG65568.1.
AL590487 Genomic DNA. Translation: CAI12649.1.
CH471121 Genomic DNA. Translation: EAW53589.1.
CH471121 Genomic DNA. Translation: EAW53590.1.
CH471121 Genomic DNA. Translation: EAW53594.1.
BC064372 mRNA. No translation available.
BC094756 mRNA. Translation: AAH94756.1. Different initiation.
BC100818 mRNA. Translation: AAI00819.1.
BC100819 mRNA. Translation: AAI00820.1.
BC100820 mRNA. Translation: AAI00821.1.
RefSeqNP_001139334.1. NM_001145862.1.
NP_870988.2. NM_181873.3.
UniGeneHs.425144.

3D structure databases

ProteinModelPortalA4FU01.
SMRA4FU01. Positions 46-535.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116109. 1 interaction.
IntActA4FU01. 1 interaction.
MINTMINT-1186094.

PTM databases

PhosphoSiteA4FU01.

Proteomic databases

PaxDbA4FU01.
PRIDEA4FU01.

Protocols and materials databases

DNASU10903.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361405; ENSP00000354941; ENSG00000014914. [A4FU01-5]
ENST00000369140; ENSP00000358136; ENSG00000014914. [A4FU01-4]
ENST00000406732; ENSP00000383948; ENSG00000014914. [A4FU01-6]
ENST00000439741; ENSP00000391668; ENSG00000014914. [A4FU01-1]
ENST00000580100; ENSP00000464585; ENSG00000264524. [A4FU01-5]
ENST00000581914; ENSP00000462570; ENSG00000264524. [A4FU01-1]
ENST00000582796; ENSP00000463324; ENSG00000264524. [A4FU01-4]
ENST00000583248; ENSP00000464592; ENSG00000264524. [A4FU01-6]
GeneID10903.
KEGGhsa:10903.
UCSCuc001etl.4. human. [A4FU01-1]
uc001etm.2. human. [A4FU01-4]
uc010pbm.1. human. [A4FU01-6]

Organism-specific databases

CTD10903.
GeneCardsGC01M149900.
H-InvDBHIX0001007.
HGNCHGNC:24307. MTMR11.
HPAHPA030351.
neXtProtNX_A4FU01.
PharmGKBPA142671303.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299000.
HOVERGENHBG108155.
InParanoidA4FU01.
OMAGPRLSWH.
OrthoDBEOG7K0ZBZ.
PhylomeDBA4FU01.
TreeFamTF315197.

Gene expression databases

BgeeA4FU01.
CleanExHS_MTMR11.
GenevestigatorA4FU01.

Family and domain databases

InterProIPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
[Graphical view]
PfamPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10903.
NextBio41411.
PROA4FU01.

Entry information

Entry nameMTMRB_HUMAN
AccessionPrimary (citable) accession number: A4FU01
Secondary accession number(s): B3KUE4 expand/collapse secondary AC list , B4DJI6, B4DQF5, B4E3Q6, Q3ZCP7, Q5SZ62, Q6P2Q8, Q99752, Q99753
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM