Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myotubularin-related protein 11

Gene

MTMR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 11
Alternative name(s):
Cisplatin resistance-associated protein
Short name:
hCRA
Gene namesi
Name:MTMR11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24307. MTMR11.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10903.
OpenTargetsiENSG00000014914.
PharmGKBiPA142671303.

Polymorphism and mutation databases

BioMutaiMTMR11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370981 – 709Myotubularin-related protein 11Add BLAST709

Proteomic databases

EPDiA4FU01.
MaxQBiA4FU01.
PaxDbiA4FU01.
PRIDEiA4FU01.

PTM databases

DEPODiA4FU01.
iPTMnetiA4FU01.
PhosphoSitePlusiA4FU01.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000014914.
CleanExiHS_MTMR11.
GenevisibleiA4FU01. HS.

Organism-specific databases

HPAiHPA030351.

Interactioni

Protein-protein interaction databases

BioGridi116109. 1 interactor.
IntActiA4FU01. 1 interactor.
MINTiMINT-1186094.
STRINGi9606.ENSP00000391668.

Structurei

3D structure databases

ProteinModelPortaliA4FU01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 639Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST444

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00860000133763.
HOVERGENiHBG108155.
InParanoidiA4FU01.
KOiK18085.
OMAiFHQGRGP.
OrthoDBiEOG091G0DYN.
PhylomeDBiA4FU01.
TreeFamiTF315197.

Family and domain databases

InterProiIPR030580. MTMR11.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 2 hits.
PTHR10807:SF51. PTHR10807:SF51. 2 hits.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4FU01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ
60 70 80 90 100
ILAWAPGVRK GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL
110 120 130 140 150
VNIGRLEAVS GLSRVQLLRP GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL
160 170 180 190 200
EPQAFQVTMA IVQARAQSNQ AQQYSGITLS KAGQGSGSRK PPIPLMETAE
210 220 230 240 250
DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL DSEVRRAFGH
260 270 280 290 300
FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV
310 320 330 340 350
VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV
360 370 380 390 400
RACLRKASDI SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL
410 420 430 440 450
FGFQSLVQRE WVAAGHPFLT RLGGTGASEE APVFLLFLDC VWQLLQQFPA
460 470 480 490 500
DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW ERGKQSGQLN SYTQVYTPGY
510 520 530 540 550
SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC PDSWLPRPQP
560 570 580 590 600
SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE
610 620 630 640 650
SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL
660 670 680 690 700
SAPTISGLQD ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL

KGRAEGDLG
Length:709
Mass (Da):79,545
Last modified:May 20, 2008 - v2
Checksum:iAC07581E26364D1F
GO
Isoform 2 (identifier: A4FU01-2) [UniParc]FASTAAdd to basket
Also known as: hCRA alpha

The sequence of this isoform differs from the canonical sequence as follows:
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:268
Mass (Da):30,116
Checksum:i3767F7815C94AAE0
GO
Isoform 3 (identifier: A4FU01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:240
Mass (Da):26,885
Checksum:iE8D6FA7FD8657504
GO
Isoform 4 (identifier: A4FU01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-75: TNF → MPP
     703-709: RAEGDLG → QSHPFWITRC

Show »
Length:640
Mass (Da):72,117
Checksum:iDB67312F79750231
GO
Isoform 5 (identifier: A4FU01-5) [UniParc]FASTAAdd to basket
Also known as: hCRA beta

The sequence of this isoform differs from the canonical sequence as follows:
     228-272: SLPRYFWVPN...HPGGSDLLRC → RLRCFSSSLI...VSGFLTPLPS
     273-709: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,195
Checksum:i24FE481676EF146D
GO
Isoform 6 (identifier: A4FU01-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     375-382: ERGDRDLN → GSGVSPLP
     383-709: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):39,372
Checksum:i2032989C2E856CAA
GO

Sequence cautioni

The sequence AAB36952 differs from that shown. Reason: Frameshift at position 8.Curated
The sequence AAB36953 differs from that shown. Reason: Frameshift at position 8.Curated
The sequence AAH94756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86W → R in BAG60917 (PubMed:14702039).Curated1
Sequence conflicti165R → G in BAG60917 (PubMed:14702039).Curated1
Sequence conflicti263H → R in BAG53406 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043598159M → V.1 PublicationCorresponds to variant rs11205303dbSNPEnsembl.1
Natural variantiVAR_043599531Q → P.Corresponds to variant rs16836857dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0338831 – 72Missing in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0338841 – 28Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_03388573 – 75TNF → MPP in isoform 4. 1 Publication3
Alternative sequenceiVSP_033886228 – 272SLPRY…DLLRC → RLRCFSSSLIVSGSSSSSFQ LILNSLSFSFLLFMTVSGFL TPLPS in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_033887258 – 268RLSWHHPGGSD → VSVMVRVMAVD in isoform 2 and isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_033888269 – 709Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST441
Alternative sequenceiVSP_033889273 – 709Missing in isoform 5. 1 PublicationAdd BLAST437
Alternative sequenceiVSP_035725375 – 382ERGDRDLN → GSGVSPLP in isoform 6. 1 Publication8
Alternative sequenceiVSP_035726383 – 709Missing in isoform 6. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_033890703 – 709RAEGDLG → QSHPFWITRC in isoform 4. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78556 mRNA. Translation: AAB36952.1. Frameshift.
U78557 mRNA. Translation: AAB36953.1. Frameshift.
AK097000 mRNA. Translation: BAG53406.1.
AK296094 mRNA. Translation: BAG58848.1.
AK298775 mRNA. Translation: BAG60917.1.
AK304820 mRNA. Translation: BAG65568.1.
AL590487 Genomic DNA. Translation: CAI12649.1.
CH471121 Genomic DNA. Translation: EAW53589.1.
CH471121 Genomic DNA. Translation: EAW53590.1.
CH471121 Genomic DNA. Translation: EAW53594.1.
BC064372 mRNA. No translation available.
BC094756 mRNA. Translation: AAH94756.1. Different initiation.
BC100818 mRNA. Translation: AAI00819.1.
BC100819 mRNA. Translation: AAI00820.1.
BC100820 mRNA. Translation: AAI00821.1.
CCDSiCCDS72901.1. [A4FU01-4]
CCDS72902.1. [A4FU01-1]
RefSeqiNP_001139334.1. NM_001145862.1. [A4FU01-1]
NP_870988.2. NM_181873.3. [A4FU01-4]
UniGeneiHs.425144.

Genome annotation databases

EnsembliENST00000369140; ENSP00000358136; ENSG00000014914. [A4FU01-4]
ENST00000439741; ENSP00000391668; ENSG00000014914. [A4FU01-1]
GeneIDi10903.
KEGGihsa:10903.
UCSCiuc001etl.5. human. [A4FU01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78556 mRNA. Translation: AAB36952.1. Frameshift.
U78557 mRNA. Translation: AAB36953.1. Frameshift.
AK097000 mRNA. Translation: BAG53406.1.
AK296094 mRNA. Translation: BAG58848.1.
AK298775 mRNA. Translation: BAG60917.1.
AK304820 mRNA. Translation: BAG65568.1.
AL590487 Genomic DNA. Translation: CAI12649.1.
CH471121 Genomic DNA. Translation: EAW53589.1.
CH471121 Genomic DNA. Translation: EAW53590.1.
CH471121 Genomic DNA. Translation: EAW53594.1.
BC064372 mRNA. No translation available.
BC094756 mRNA. Translation: AAH94756.1. Different initiation.
BC100818 mRNA. Translation: AAI00819.1.
BC100819 mRNA. Translation: AAI00820.1.
BC100820 mRNA. Translation: AAI00821.1.
CCDSiCCDS72901.1. [A4FU01-4]
CCDS72902.1. [A4FU01-1]
RefSeqiNP_001139334.1. NM_001145862.1. [A4FU01-1]
NP_870988.2. NM_181873.3. [A4FU01-4]
UniGeneiHs.425144.

3D structure databases

ProteinModelPortaliA4FU01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116109. 1 interactor.
IntActiA4FU01. 1 interactor.
MINTiMINT-1186094.
STRINGi9606.ENSP00000391668.

PTM databases

DEPODiA4FU01.
iPTMnetiA4FU01.
PhosphoSitePlusiA4FU01.

Polymorphism and mutation databases

BioMutaiMTMR11.

Proteomic databases

EPDiA4FU01.
MaxQBiA4FU01.
PaxDbiA4FU01.
PRIDEiA4FU01.

Protocols and materials databases

DNASUi10903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369140; ENSP00000358136; ENSG00000014914. [A4FU01-4]
ENST00000439741; ENSP00000391668; ENSG00000014914. [A4FU01-1]
GeneIDi10903.
KEGGihsa:10903.
UCSCiuc001etl.5. human. [A4FU01-1]

Organism-specific databases

CTDi10903.
DisGeNETi10903.
GeneCardsiMTMR11.
H-InvDBHIX0001007.
HGNCiHGNC:24307. MTMR11.
HPAiHPA030351.
neXtProtiNX_A4FU01.
OpenTargetsiENSG00000014914.
PharmGKBiPA142671303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00860000133763.
HOVERGENiHBG108155.
InParanoidiA4FU01.
KOiK18085.
OMAiFHQGRGP.
OrthoDBiEOG091G0DYN.
PhylomeDBiA4FU01.
TreeFamiTF315197.

Miscellaneous databases

ChiTaRSiMTMR11. human.
GenomeRNAii10903.
PROiA4FU01.

Gene expression databases

BgeeiENSG00000014914.
CleanExiHS_MTMR11.
GenevisibleiA4FU01. HS.

Family and domain databases

InterProiIPR030580. MTMR11.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 2 hits.
PTHR10807:SF51. PTHR10807:SF51. 2 hits.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTMRB_HUMAN
AccessioniPrimary (citable) accession number: A4FU01
Secondary accession number(s): B3KUE4
, B4DJI6, B4DQF5, B4E3Q6, Q3ZCP7, Q5SZ62, Q6P2Q8, Q99752, Q99753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.