A4FTV9 (A4FTV9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone H2A RuleBase RU003556

Gene names

Name:	HIST1H2AK EMBL AAH34487.1
Synonyms:	HIST1H2AG EMBL EAX03083.1, HIST1H2AI EMBL EAX03107.1, HIST1H2AL EMBL EAX03118.1, HIST1H2AM EMBL EAX03123.1
ORF Names:	hCG_1640463 EMBL EAX03107.1, hCG_1640467 EMBL EAX03123.1, hCG_1641458 EMBL EAX03083.1, hCG_1643754 EMBL EAX03113.1, hCG_1743060 EMBL EAX03118.1

Organism

Homo sapiens (Human) EMBL AAH34487.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity. RuleBase RU003556
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone H2A family. RuleBase RU003767

Ontologies

Keywords
Cellular component	Chromosome Nucleosome core SAAS SAAS002119 RuleBase RU000527 Nucleus SAAS SAAS002119 RuleBase RU000527
Ligand	DNA-binding
Gene Ontology (GO)
Biological_process	nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4FTV9 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 48DD539793FE8256	FASTA	130	14,091
	10 20 30 40 50 60 MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 70 80 90 100 110 120 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 130 TESHHKAKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH34487.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAG34882.1, Thymus EMBL BAG35157.1 and Tongue EMBL BAG34709.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC034487 mRNA. Translation: AAH34487.1. AK311766 mRNA. Translation: BAG34709.1. AK311941 mRNA. Translation: BAG34882.1. AK312224 mRNA. Translation: BAG35157.1. CH471081 Genomic DNA. Translation: EAX03083.1. CH471081 Genomic DNA. Translation: EAX03107.1. CH471081 Genomic DNA. Translation: EAX03113.1. CH471081 Genomic DNA. Translation: EAX03118.1. CH471081 Genomic DNA. Translation: EAX03123.1.
IPI	IPI00291764.
RefSeq	NP_003500.1. NM_003509.2. NP_003501.1. NM_003510.2. NP_003502.1. NM_003511.2. NP_003505.1. NM_003514.2. NP_066408.1. NM_021064.4.
UniGene	Hs.134999. Hs.233568. Hs.51011. Hs.534035. Hs.734717.
3D structure databases
ProteinModelPortal	A4FTV9.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FTV9.
Proteomic databases
PRIDE	A4FTV9.
Protocols and materials databases
DNASU	8329. 8330. 8332. 8969.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8329. 8330. 8332. 8336. 8969.
KEGG	hsa:8329. hsa:8330. hsa:8332. hsa:8336. hsa:8969.
Organism-specific databases
CTD	8329. 8330. 8332. 8336. 8969.
PharmGKB	PA29114.
Phylogenomic databases
HOVERGEN	HBG009342.
KO	K11251.
OMA	KSRINPR.
PhylomeDB	A4FTV9.
Gene expression databases
ArrayExpress	A4FTV9.
Bgee	A4FTV9.
Family and domain databases
Gene3D	1.10.20.10. 1 hit.
InterPro	IPR009072. Histone-fold. IPR007125. Histone_core_D. IPR002119. Histone_H2A. [Graphical view]
Pfam	PF00125. Histone. 1 hit. [Graphical view]
PRINTS	PR00620. HISTONEH2A.
SMART	SM00414. H2A. 1 hit. [Graphical view]
SUPFAM	SSF47113. Histone-fold. 1 hit.
PROSITE	PS00046. HISTONE_H2A. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	31190.

Entry information

Entry name

A4FTV9_HUMAN

Accession

Primary (citable) accession number: A4FTV9

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.