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Protein

Histone H2A

Gene

HIST1H2AK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:HIST1H2AKImported
Synonyms:HIST1H2AGImported, HIST1H2AIImported, HIST1H2ALImported, HIST1H2AMImported
ORF Names:hCG_1640463Imported, hCG_1640467Imported, hCG_1641458Imported, hCG_1643754Imported, hCG_1743060Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000196747.4.
HostDB:ENSG00000196787.3.
HostDB:ENSG00000275221.1.
HostDB:ENSG00000276903.1.
HostDB:ENSG00000278677.1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29114.

Expressioni

Gene expression databases

BgeeiENSG00000196747.
ExpressionAtlasiA4FTV9. baseline and differential.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiA4FTV9. 2 interactors.

Structurei

3D structure databases

SMRiA4FTV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89HistoneInterPro annotationAdd BLAST85
Domaini92 – 126Histone_H2A_CInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
HOVERGENiHBG009342.
KOiK11251.
OMAiKGKYAKR.
OrthoDBiEOG091G0XGD.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00046. HISTONE_H2A. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FTV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK
110 120 130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Length:130
Mass (Da):14,091
Last modified:April 17, 2007 - v1
Checksum:i48DD539793FE8256
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034487 mRNA. Translation: AAH34487.1.
AK311766 mRNA. Translation: BAG34709.1.
AK311941 mRNA. Translation: BAG34882.1.
AK312224 mRNA. Translation: BAG35157.1.
CH471081 Genomic DNA. Translation: EAX03083.1.
CH471081 Genomic DNA. Translation: EAX03107.1.
CH471081 Genomic DNA. Translation: EAX03113.1.
CH471081 Genomic DNA. Translation: EAX03118.1.
CH471081 Genomic DNA. Translation: EAX03123.1.
RefSeqiNP_003500.1. NM_003509.2.
NP_003501.1. NM_003510.2.
NP_003502.1. NM_003511.2.
NP_003505.1. NM_003514.2.
NP_066408.1. NM_021064.4.
UniGeneiHs.134999.
Hs.233568.
Hs.51011.
Hs.534035.
Hs.734717.

Genome annotation databases

GeneIDi8329.
8330.
8332.
8336.
8969.
KEGGihsa:8329.
hsa:8330.
hsa:8332.
hsa:8336.
hsa:8969.

Similar proteinsi

Entry informationi

Entry nameiA4FTV9_HUMAN
AccessioniPrimary (citable) accession number: A4FTV9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.