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Protein

Histone H2A

Gene

HIST1H2AK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:HIST1H2AKImported
Synonyms:HIST1H2AGImported, HIST1H2AIImported, HIST1H2ALImported, HIST1H2AMImported
ORF Names:hCG_1640463Imported, hCG_1640467Imported, hCG_1641458Imported, hCG_1643754Imported, hCG_1743060Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29114.

Expressioni

Gene expression databases

BgeeiENSG00000184348.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000352627.

Structurei

3D structure databases

SMRiA4FTV9. Positions 14-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8985HistoneInterPro annotationAdd
BLAST
Domaini92 – 12635Histone_H2A_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
HOVERGENiHBG009342.
KOiK11251.
OMAiGRIVPRH.
OrthoDBiEOG091G0XGD.
PhylomeDBiA4FTV9.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FTV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK
110 120 130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Length:130
Mass (Da):14,091
Last modified:April 17, 2007 - v1
Checksum:i48DD539793FE8256
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034487 mRNA. Translation: AAH34487.1.
AK311766 mRNA. Translation: BAG34709.1.
AK311941 mRNA. Translation: BAG34882.1.
AK312224 mRNA. Translation: BAG35157.1.
CH471081 Genomic DNA. Translation: EAX03083.1.
CH471081 Genomic DNA. Translation: EAX03107.1.
CH471081 Genomic DNA. Translation: EAX03113.1.
CH471081 Genomic DNA. Translation: EAX03118.1.
CH471081 Genomic DNA. Translation: EAX03123.1.
RefSeqiNP_003500.1. NM_003509.2.
NP_003501.1. NM_003510.2.
NP_003502.1. NM_003511.2.
NP_003505.1. NM_003514.2.
NP_066408.1. NM_021064.4.
UniGeneiHs.134999.
Hs.233568.
Hs.51011.
Hs.534035.
Hs.734717.

Genome annotation databases

GeneIDi8329.
8330.
8332.
8336.
8969.
KEGGihsa:8329.
hsa:8330.
hsa:8332.
hsa:8336.
hsa:8969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034487 mRNA. Translation: AAH34487.1.
AK311766 mRNA. Translation: BAG34709.1.
AK311941 mRNA. Translation: BAG34882.1.
AK312224 mRNA. Translation: BAG35157.1.
CH471081 Genomic DNA. Translation: EAX03083.1.
CH471081 Genomic DNA. Translation: EAX03107.1.
CH471081 Genomic DNA. Translation: EAX03113.1.
CH471081 Genomic DNA. Translation: EAX03118.1.
CH471081 Genomic DNA. Translation: EAX03123.1.
RefSeqiNP_003500.1. NM_003509.2.
NP_003501.1. NM_003510.2.
NP_003502.1. NM_003511.2.
NP_003505.1. NM_003514.2.
NP_066408.1. NM_021064.4.
UniGeneiHs.134999.
Hs.233568.
Hs.51011.
Hs.534035.
Hs.734717.

3D structure databases

SMRiA4FTV9. Positions 14-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352627.

Protocols and materials databases

DNASUi8329.
8330.
8332.
8969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8329.
8330.
8332.
8336.
8969.
KEGGihsa:8329.
hsa:8330.
hsa:8332.
hsa:8336.
hsa:8969.

Organism-specific databases

CTDi8329.
8330.
8332.
8336.
8969.
PharmGKBiPA29114.

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
HOVERGENiHBG009342.
KOiK11251.
OMAiGRIVPRH.
OrthoDBiEOG091G0XGD.
PhylomeDBiA4FTV9.

Gene expression databases

BgeeiENSG00000184348.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4FTV9_HUMAN
AccessioniPrimary (citable) accession number: A4FTV9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.