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A4FNW6 (A4FNW6_SACEN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase 2 HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540
Alternative name(s):
Adenosine aminohydrolase 2 HAMAP MF_00540
Gene names
Name:add EMBL CAM05741.1
Synonyms:add2 HAMAP MF_00540
Ordered Locus Names:SACE_6573
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 SAAS SAAS006330

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2111Proton donor By similarity HAMAP MF_00540
Metal binding191Zinc; catalytic By similarity HAMAP MF_00540
Metal binding211Zinc; catalytic By similarity HAMAP MF_00540
Metal binding2081Zinc; catalytic By similarity HAMAP MF_00540
Metal binding3001Zinc; catalytic By similarity HAMAP MF_00540
Binding site211Substrate By similarity HAMAP MF_00540
Binding site231Substrate By similarity HAMAP MF_00540
Binding site1811Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
Site2321Important for catalytic activity By similarity HAMAP MF_00540

Sequences

Sequence LengthMass (Da)Tools
A4FNW6 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: B192FDD007F41D8C

FASTA36239,943
        10         20         30         40         50         60 
MATPVSFDTI RSAPKVLLHD HLDGGLRPQT VIDLAAETGY SGLPHTDAAE LGEWFHRAAD 

        70         80         90        100        110        120 
SGSLERYLET FSHTVGVMQT PDALVRVAAE CAEDLAADGV VYAEVRYAPE LFQDGGMTID 

       130        140        150        160        170        180 
EVVQAVQDGF REGERRVAES GKRIRIGTLL CAMRQNARAT EIANLAVRYR DAEVVGFDIA 

       190        200        210        220        230        240 
GPEAGFPPTR NLDAFEYLRQ QNAHFTIHAG EAFGLPSIWE AIQHCGAERL GHGVRIVDDI 

       250        260        270        280        290        300 
KVDDNGEVQL GRLASYVRDR RIPLEMCPSS NLQTGAAPSL AEHPIGLLAR LRFRVTVNTD 

       310        320        330        340        350        360 
NRLMSHCSMS SEFHALHETF GYDWADMQWF TVNAMKSSFL GFDERLAIIN DVVKPGYARL 


MA

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References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM420293 Genomic DNA. Translation: CAM05741.1.
RefSeqYP_001108666.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4FNW6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4FNW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4946305.
GenomeReviewsGene locus SACE_6573 in contig AM420293_GR.
KEGGsen:SACE_6573.
PATRIC23420564. VBISacEry28377_6565.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAPYYMAMN.
PhylomeDBA4FNW6.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycSERY405948:SACE_6573-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4FNW6_SACEN
AccessionPrimary (citable) accession number: A4FNW6
Entry history
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info