A4FND0 (A4FND0_SACEN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
2-oxoglutarate dehydrogenase E1 component EMBL CAM05555.1
EC=1.2.4.2 EMBL CAM05555.1

Gene names

Name:	sucA EMBL CAM05555.1
Ordered Locus Names:	SACE_6385

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	1206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423

Ontologies

Keywords
Ligand	Thiamine pyrophosphate SAAS SAAS001017
Molecular function	Oxidoreductase EMBL CAM05555.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4FND0 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: D6414CF26CEF84DB	FASTA	1,206	132,529
	10 20 30 40 50 60 MYEQFLHDPT SVDSAWHEFF ADYKPGQATE TTAAATGSAA APKATATAAR VVETNGQTPP 70 80 90 100 110 120 PSATAPSKPK PAEPKPSPQE AAKAAPVKEA PAGEQAKPLR GAAAAIAKNM EQSLTVPTAT 130 140 150 160 170 180 SVRAVPAKLL FDNRIVINNH LKRNKGGKVS FTHLIGYALI RALRNHPDMN RHYGEDAKGK 190 200 210 220 230 240 PAVVTPEHVN LGLAIDMPAK DGSRSLVVAS IKGCEEMTFQ QFWQAYEDII RKARNSALTA 250 260 270 280 290 300 DDFSGTTISL TNPGPSGTNH SVPRLTKGQS AIIGVGAMDY PAEFQGASEQ ALVDMGISKI 310 320 330 340 350 360 VTLTSTYDHR VIQGAESGDF LRTVHQLLLG ENGFYDDIFT SLRIPYEPVR WTRDIPEGAV 370 380 390 400 410 420 DKTARVLELI DAYRTRGHLM ADIDPLNYRQ RRHEDLDVLS HSLTLWDLDR TFAVGGFAGK 430 440 450 460 470 480 ERMKLRDVLG VLRDSYCRTV GVEYMHILEP DEREWLQGRV EKPHTKPEPT EQKYILSKLN 490 500 510 520 530 540 AAEAFETFLQ TKYVGQKRFS LEGAETVVPL LDAVLDTAAA SELDEVVIGM PHRGRLNVLA 550 560 570 580 590 600 NIVGKPISQI FREFEGNLDP GQAHGSGDVK YHLGAEGKYF RMFGDGETKV SLTSNPSHLE 610 620 630 640 650 660 AVDPVLEGIV RAKQDILDKG QEGFTVLPVL LHGDAAFAGQ GVVAETLNLS LLRGYRTGGT 670 680 690 700 710 720 VHVIVNNQVG YTTAPEHSRS SKYSTDVAKM IGAPVFHVNG DDPEACVWVA KLAVEYRQAF 730 740 750 760 770 780 GKDVVIDMVC YRRRGHNEGD DPSMTQPAMY DAIDKMRSVR KTYTEALIGR GDITVEEAEK 790 800 810 820 830 840 ALKDYASQLE HVFNEVRELE KHPPEPSPSV ESEQVVPQGL ATAIPVDTLK RIADAQVNMP 850 860 870 880 890 900 EGFTPHSRVK PVLERRAKMA TEGGIDWAFG ELLAFGSLTM EGRPVRLTGQ DSRRGTFGQR 910 920 930 940 950 960 HSVLIDRKTG AEYTPLQNLS EDQAKFLVYD SALSEFAAMG FEYGYSVANP DALVLWEAQF 970 980 990 1000 1010 1020 GDFFNGAQSI IDEFISSGEA KWGQRSDVVL LLPHGHEGQG PDHSSARIER WLQLCAEGSM 1030 1040 1050 1060 1070 1080 TVAMPSTPAN YFHLLRRHAL DGIHRPLVVF TPKSMLRLKA ATSPVEDFTE GKFTSVIDDP 1090 1100 1110 1120 1130 1140 TQPDPASVRR VVLCTGKLYY ELAAEKAKQG HDDTAVVRLE QLYPLPHRKL GRLLERYSNA 1150 1160 1170 1180 1190 1200 TDVRWVQEEP ANQGAWPFLG LALPELFPER LAGLRRVSRR PMAAPATGMA KVHEVEQAEV VQGAFA

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM05555.1.
RefSeq	YP_001108480.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FND0.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FND0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4946115.
GenomeReviews	Gene locus SACE_6385 in contig AM420293_GR.
KEGG	sen:SACE_6385.
PATRIC	23420158. VBISacEry28377_6365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HBG289950.
OMA	EGDEPAF.
PhylomeDB	A4FND0.
ProtClustDB	PRK12270.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_6385-MONOMER.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K01616.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4FND0_SACEN

Accession

Primary (citable) accession number: A4FND0

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)