A4FMK4 (A4FMK4_SACEN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase HAMAP MF_00151
EC=2.7.7.3 HAMAP MF_00151

Alternative name(s):
Dephospho-CoA pyrophosphorylase HAMAP MF_00151
Pantetheine-phosphate adenylyltransferase HAMAP MF_00151

Gene names

Name:	coaD HAMAP MF_00151 EMBL CAM05279.1
Ordered Locus Names:	SACE_6106

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family. HAMAP MF_00151

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis HAMAP MF_00151
Cellular component	Cytoplasm HAMAP MF_00151
Ligand	ATP-binding HAMAP MF_00151 Nucleotide-binding
Molecular function	Nucleotidyltransferase HAMAP MF_00151 EMBL CAM05279.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4FMK4 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: FDFADB6E79E9B791	FASTA	156	17,569
	10 20 30 40 50 60 MCPGSYDPVT NGHLDIIERA AGLFDEVVVA VLVNKSKKSL FTVDERLEML REVTSQWPNV 70 80 90 100 110 120 RIDSWHGLLV DYCREHHIGA IVKGLRAVSD FDYELQMAQM NQRLSGVETL FMSTNPLYSF 130 140 150 LASSLVKEVA TYGGDVSNLL PPKIEQRLLE RLAEQS

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM05279.1.
RefSeq	YP_001108204.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FMK4.
SMR	A4FMK4. Positions 2-152.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FMK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4945835.
GenomeReviews	Gene locus SACE_6106 in contig AM420293_GR.
KEGG	sen:SACE_6106.
PATRIC	23419580. VBISacEry28377_6080.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0669.
HOGENOM	HBG288308.
OMA	YLIRSAR.
PhylomeDB	A4FMK4.
ProtClustDB	CLSK2536611.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_6106-MONOMER.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4FMK4_SACEN

Accession

Primary (citable) accession number: A4FMK4

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)