A4FLS4 (A4FLS4_SACEN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III alpha subunit EMBL CAM04999.1
EC=2.7.7.7 EMBL CAM04999.1

Gene names

Name:	dnaE EMBL CAM04999.1
Ordered Locus Names:	SACE_5815

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	1194 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS004013

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS004013
Cellular component	Cytoplasm SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4FLS4 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 77A8755083D640B3	FASTA	1,194	131,197
	10 20 30 40 50 60 MPVDPFVHLH VHTEYSMLDG AAKVGALFAE AQRLEMPAVG MTDHGNMFGA DEFYQQAKKT 70 80 90 100 110 120 GIKPIIGIEA YLAPGSRFHK KPVFWGEAKQ RGTDEYGEGG DVSGAGAYTH MTMLARNATG 130 140 150 160 170 180 LRNLFTLSSR ASMEGQYRKP RMDRELVAEY AEGIIATTGC PSGEVQTRLR LRQFDEAMQA 190 200 210 220 230 240 ASDYKDIFGA ENFFLELMDH GLPIERSVRE GLLKIAKELG LKPVATNDSH YVTADQAESH 250 260 270 280 290 300 GALLCVQSGK TLNDESRFKF DGDGYYLKSA AEMREYWDKE VPGAADNTLL IAERVESYED 310 320 330 340 350 360 VWSFQDRMPR VTDGSGKTER QLLEAEVEQY LPTRYPEGAT QECLDRIKVE LDVLDTKGYC 370 380 390 400 410 420 AYFLVVGDLT RWAKSQGIHV GPGRGSAAGS LLAYILHITN LDPLEHGLIF ERFLNPERDS 430 440 450 460 470 480 PPDIDLDFDD RRRDEVLQYA IDKYGRDKVA QVITFGKIKT KAAIKDSARV HHGQPGFAIA 490 500 510 520 530 540 DKISKALPPP IAAKDIPLSG IVDPQHERYA EAAEVRNLIE TDPSVSQIFD TARGLEGLIR 550 560 570 580 590 600 NAGVHACAVI LSSQPLMGTV PLWARDDGSI ITGWDYPSCE AIGLLKMDFL GLSNLTILGD 610 620 630 640 650 660 ALKMVKANHD REIDLSNLGL DDAKTYELLA RGESLGVFQL EGGGMRELLK RMQPTEFADI 670 680 690 700 710 720 VACNALYRPG PMEVNAHNDY ADRKNGKKPV EPIHPDLDEP LKDILSETYG LIVYQEQIMA 730 740 750 760 770 780 IAQKVAGYSL GRADILRRAM GKKKKEVLDQ EFEGFQAGMR EQGFRDEAID KLWATVLPFA 790 800 810 820 830 840 GYAFNKSHAA GYALVAYWTA YLKANYPAEY MAALLTSNGD NKDKMAVYLA ECRRMGVKVL 850 860 870 880 890 900 SPDVNDSLND FTAVGSDIRF GLSAVRNVGS NVVASIAKVR EDKGRYSSFT DFLDKSETVA 910 920 930 940 950 960 CNKRVIESLI KAGAFDSLGH TRMSLAQHHE AAVDAVIGLK RQQALGQFDL FGGGDDAGGE 970 980 990 1000 1010 1020 ESSSPLAHLQ FTPDEWPRKQ MLSYEREMLG LYVSAHPLDG AERLLAPYQD TGIAELVGGE 1030 1040 1050 1060 1070 1080 REAGKDQVKI AGMISGIQRR INKNGHPWAI VTLEDLDASV EVLFFPKSYE MFADCLVEDT 1090 1100 1110 1120 1130 1140 AIAVKGRINE REGTISIFAS DAVPVDISAA ETDPGTSPAF VIKVPASRVD RSLVAELKRT 1150 1160 1170 1180 1190 LQAHSGTVPV HVKLQGPRGV TRLALSSDYF VSTENGLQGE LKGLLGAGCF ETVL

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM04999.1.
RefSeq	YP_001107924.1. NC_009142.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4FLS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4945555.
GenomeReviews	Gene locus SACE_5815 in contig AM420293_GR.
KEGG	sen:SACE_5815.
PATRIC	23418974. VBISacEry28377_5777.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	RVLQMPY.
ProtClustDB	PRK05673.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_5815-MONOMER.
Family and domain databases
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K02337.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4FLS4_SACEN

Accession

Primary (citable) accession number: A4FLS4

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)