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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:SACE_5701
OrganismiSaccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
Proteomesi
  • UP000006728 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000476951 – 367AminomethyltransferaseAdd BLAST367

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SeryN2_010100023989

Structurei

3D structure databases

ProteinModelPortaliA4FLG1
SMRiA4FLG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43 Bacteria
COG0404 LUCA
HOGENOMiHOG000239381
KOiK00605
OMAiMPVQYPA
OrthoDBiPOG091H04FV

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
HAMAPiMF_00259 GcvT, 1 hit
InterProiView protein in InterPro
IPR006223 GCS_T
IPR022903 GCS_T_bac
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

A4FLG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPRQTPLH EIHEALGATF TEFAGWRMPL RYTGDAAEHN AVRTAAGLFD
60 70 80 90 100
LTHMGEIRIS GPQAPEALDY ALVANASAIT VGRARYTMIC NSEGGVLDDL
110 120 130 140 150
IVYRLGEQEY LVVANAANAA VVSAELAERV ARFEASHEDV SDDYALIAVQ
160 170 180 190 200
GPKAVDILAP LTSTDLSTVK YYAGYRSEVA GARVMLARTG YTGEDGFELF
210 220 230 240 250
TSPADAPAVW QALADSGAEH GLRPAGLSCR DTLRLEAGMP LYGNELSAEL
260 270 280 290 300
TPFHANLGRV VKLDKPGDFV GKAPLAAAAE KPTERKLVGL RTDQRRAPRH
310 320 330 340 350
GYRVLDAGGA EIGVVTSGAP SPTLGHPIAM AYVDRDHAEP GTALQVDIRG
360
TAVPVEVVAL PFYRRNA
Length:367
Mass (Da):39,090
Last modified:April 17, 2007 - v1
Checksum:i5B00810A3E950A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA Translation: CAM04886.1
RefSeqiWP_009948208.1, NZ_PDBV01000001.1

Genome annotation databases

EnsemblBacteriaiCAM04886; CAM04886; SACE_5701
KEGGisen:SACE_5701

Similar proteinsi

Entry informationi

Entry nameiGCST_SACEN
AccessioniPrimary (citable) accession number: A4FLG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health