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A4FL80

- FTHS_SACEN

UniProt

A4FL80 - FTHS_SACEN

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, SACE_5619
Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SACE_5619
OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
ProteomesiUP000006728: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293057Add
BLAST

Proteomic databases

PRIDEiA4FL80.

Interactioni

Protein-protein interaction databases

STRINGi405948.SACE_5619.

Structurei

3D structure databases

ProteinModelPortaliA4FL80.
SMRiA4FL80. Positions 6-563.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FL80-1 [UniParc]FASTAAdd to Basket

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MTVPSDLDIS RATALRPLED IAAQLGLGPH LLEPYGHNVA KISLDAIEEL    50
SDRPQARYVV VSAITPTPLG EGKTTTTVGL GQALRHLGKV SAVAVRQPSM 100
GPTFGIKGGA AGGGYSQVVP MEALNLHLTG DMHAVTAAHN LLSAMLDNHL 150
HKGNRLGVDP HRITWRRVLD VNDRDLRNIV TGMGGRADGT PRQTGFDITA 200
ASEVMAVLAL STSLRDMRRR LGRIVVGYTR DGSPVTAEDL RAAGAMTAIM 250
REAIKPNLMQ TTENTPVLVH AGPFGNIAHG NSSVVADRIA GRCADYLVTE 300
AGFGADMGAE RFFNIKCRTS GMRPDAAVLV ATVRALKAHS GRYKVVAGRP 350
LPPEMLAENP DDVLAGAENL RKQIDNIRLH GVSPVVAVNA FPTDHGSEHD 400
AIRRVAEEEG ARVAVSNHYS EGGKGALELA EVVVEAAEEP NRFRLLYPDS 450
ADLRTKIETI ATRVYGADGV SYQPAAARAL ADYEAIGFGS LPVCIAKTHL 500
SLSSDPSLLG APTGWTLPVR EVRASIGAGF IYAICGEMRT MPGLGSHPAA 550
ERIDIDEHGQ IVGLS 565
Length:565
Mass (Da):59,922
Last modified:April 17, 2007 - v1
Checksum:i8C202C45707AE1E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM04805.1.
RefSeqiWP_009944604.1. NZ_ABFV01000015.1.
YP_001107730.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM04805; CAM04805; SACE_5619.
GeneIDi4945361.
KEGGisen:SACE_5619.
PATRICi23418570. VBISacEry28377_5575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM04805.1 .
RefSeqi WP_009944604.1. NZ_ABFV01000015.1.
YP_001107730.1. NC_009142.1.

3D structure databases

ProteinModelPortali A4FL80.
SMRi A4FL80. Positions 6-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405948.SACE_5619.

Proteomic databases

PRIDEi A4FL80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM04805 ; CAM04805 ; SACE_5619 .
GeneIDi 4945361.
KEGGi sen:SACE_5619.
PATRICi 23418570. VBISacEry28377_5575.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 23338.

Entry informationi

Entry nameiFTHS_SACEN
AccessioniPrimary (citable) accession number: A4FL80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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