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A4FL80

- FTHS_SACEN

UniProt

A4FL80 - FTHS_SACEN

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SACE_5619
OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
ProteomesiUP000006728: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293057Add
BLAST

Proteomic databases

PRIDEiA4FL80.

Interactioni

Protein-protein interaction databases

STRINGi405948.SACE_5619.

Structurei

3D structure databases

ProteinModelPortaliA4FL80.
SMRiA4FL80. Positions 6-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FL80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVPSDLDIS RATALRPLED IAAQLGLGPH LLEPYGHNVA KISLDAIEEL
60 70 80 90 100
SDRPQARYVV VSAITPTPLG EGKTTTTVGL GQALRHLGKV SAVAVRQPSM
110 120 130 140 150
GPTFGIKGGA AGGGYSQVVP MEALNLHLTG DMHAVTAAHN LLSAMLDNHL
160 170 180 190 200
HKGNRLGVDP HRITWRRVLD VNDRDLRNIV TGMGGRADGT PRQTGFDITA
210 220 230 240 250
ASEVMAVLAL STSLRDMRRR LGRIVVGYTR DGSPVTAEDL RAAGAMTAIM
260 270 280 290 300
REAIKPNLMQ TTENTPVLVH AGPFGNIAHG NSSVVADRIA GRCADYLVTE
310 320 330 340 350
AGFGADMGAE RFFNIKCRTS GMRPDAAVLV ATVRALKAHS GRYKVVAGRP
360 370 380 390 400
LPPEMLAENP DDVLAGAENL RKQIDNIRLH GVSPVVAVNA FPTDHGSEHD
410 420 430 440 450
AIRRVAEEEG ARVAVSNHYS EGGKGALELA EVVVEAAEEP NRFRLLYPDS
460 470 480 490 500
ADLRTKIETI ATRVYGADGV SYQPAAARAL ADYEAIGFGS LPVCIAKTHL
510 520 530 540 550
SLSSDPSLLG APTGWTLPVR EVRASIGAGF IYAICGEMRT MPGLGSHPAA
560
ERIDIDEHGQ IVGLS
Length:565
Mass (Da):59,922
Last modified:April 17, 2007 - v1
Checksum:i8C202C45707AE1E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM04805.1.
RefSeqiYP_001107730.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM04805; CAM04805; SACE_5619.
GeneIDi4945361.
KEGGisen:SACE_5619.
PATRICi23418570. VBISacEry28377_5575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM04805.1 .
RefSeqi YP_001107730.1. NC_009142.1.

3D structure databases

ProteinModelPortali A4FL80.
SMRi A4FL80. Positions 6-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405948.SACE_5619.

Proteomic databases

PRIDEi A4FL80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM04805 ; CAM04805 ; SACE_5619 .
GeneIDi 4945361.
KEGGi sen:SACE_5619.
PATRICi 23418570. VBISacEry28377_5575.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 23338.

Entry informationi

Entry nameiFTHS_SACEN
AccessioniPrimary (citable) accession number: A4FL80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3