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A4FL80

- FTHS_SACEN

UniProt

A4FL80 - FTHS_SACEN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SACE_5619
    OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
    Taxonomic identifieri405948 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
    ProteomesiUP000006728: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293057Add
    BLAST

    Proteomic databases

    PRIDEiA4FL80.

    Interactioni

    Protein-protein interaction databases

    STRINGi405948.SACE_5619.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FL80.
    SMRiA4FL80. Positions 6-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FL80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVPSDLDIS RATALRPLED IAAQLGLGPH LLEPYGHNVA KISLDAIEEL    50
    SDRPQARYVV VSAITPTPLG EGKTTTTVGL GQALRHLGKV SAVAVRQPSM 100
    GPTFGIKGGA AGGGYSQVVP MEALNLHLTG DMHAVTAAHN LLSAMLDNHL 150
    HKGNRLGVDP HRITWRRVLD VNDRDLRNIV TGMGGRADGT PRQTGFDITA 200
    ASEVMAVLAL STSLRDMRRR LGRIVVGYTR DGSPVTAEDL RAAGAMTAIM 250
    REAIKPNLMQ TTENTPVLVH AGPFGNIAHG NSSVVADRIA GRCADYLVTE 300
    AGFGADMGAE RFFNIKCRTS GMRPDAAVLV ATVRALKAHS GRYKVVAGRP 350
    LPPEMLAENP DDVLAGAENL RKQIDNIRLH GVSPVVAVNA FPTDHGSEHD 400
    AIRRVAEEEG ARVAVSNHYS EGGKGALELA EVVVEAAEEP NRFRLLYPDS 450
    ADLRTKIETI ATRVYGADGV SYQPAAARAL ADYEAIGFGS LPVCIAKTHL 500
    SLSSDPSLLG APTGWTLPVR EVRASIGAGF IYAICGEMRT MPGLGSHPAA 550
    ERIDIDEHGQ IVGLS 565
    Length:565
    Mass (Da):59,922
    Last modified:April 17, 2007 - v1
    Checksum:i8C202C45707AE1E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM04805.1.
    RefSeqiWP_009944604.1. NZ_ABFV01000015.1.
    YP_001107730.1. NC_009142.1.

    Genome annotation databases

    EnsemblBacteriaiCAM04805; CAM04805; SACE_5619.
    GeneIDi4945361.
    KEGGisen:SACE_5619.
    PATRICi23418570. VBISacEry28377_5575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM04805.1 .
    RefSeqi WP_009944604.1. NZ_ABFV01000015.1.
    YP_001107730.1. NC_009142.1.

    3D structure databases

    ProteinModelPortali A4FL80.
    SMRi A4FL80. Positions 6-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405948.SACE_5619.

    Proteomic databases

    PRIDEi A4FL80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM04805 ; CAM04805 ; SACE_5619 .
    GeneIDi 4945361.
    KEGGi sen:SACE_5619.
    PATRICi 23418570. VBISacEry28377_5575.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
      Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
      Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL 23338.

    Entry informationi

    Entry nameiFTHS_SACEN
    AccessioniPrimary (citable) accession number: A4FL80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3