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Protein

Catalase-peroxidase

Gene

katG

Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Transition state stabilizerUniRule annotation
Active sitei102 – 1021Proton acceptorUniRule annotation
Metal bindingi268 – 2681Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei5232. SerCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:SACE_4668
OrganismiSaccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
Proteomesi
  • UP000006728 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Catalase-peroxidasePRO_0000354900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki101 ↔ 227Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-253)UniRule annotation
Cross-linki227 ↔ 253Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-101)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SeryN2_010100005622.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FIR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSPDATTG GCPVAHGDRL PHPTQGGANT HWWPNRLNLK LLAKNPAVAD
60 70 80 90 100
PMGEEFDYAA EFKTLDLPAV KADIQEVLTT SQDWWPADFG HYGPLMIRMA
110 120 130 140 150
WHSAGTYRVS DGRGGAGTGQ QRFAPLNSWP DNVSLDKARR LLWPVKQKYG
160 170 180 190 200
RKLSWADLMI LAGNVALESM GFETFGFAGG RVDAWEPEDD VYWGAETTWL
210 220 230 240 250
GSDQRISGGE QRELEKPLGA THMGLIYVNP EGPEGKPDPV AAARDIRETF
260 270 280 290 300
GRMAMNDEET VALIAGGHTF GKTHGAAPDS NLGPDSEAAP LEAQGLGWHN
310 320 330 340 350
SHGTGKGADT ITSGLEVTWT STPTQWSNGF FENLFGYEYE LYQGPGGGWQ
360 370 380 390 400
WRPKDGAGEG TVPDAHDPSK KIAPNMLTTD LSLKVDPIYE PISRRFWENP
410 420 430 440 450
QEFADAFARA WFKLTHRDMG PADRYLGPEV PSEELIWQDP IPKPDHELVG
460 470 480 490 500
PAEIAELKGR IAESGLTVRQ LVSTAWAAAS TFRGSDKRGG ANGGRIRLEP
510 520 530 540 550
QRSWEVNEPD QLATVISTLE GIQESFNAGS GAKKVSFADL VVLAGGVGVE
560 570 580 590 600
QAAQAAGFDV EVPFTPGRGD ATAEQTDVES FSHLEPSSDG FRNYLGKGHP
610 620 630 640 650
LPAEYQLVDK ANLLTLSAPE MTVLVGGLRV LGANYQQSEQ GVFTEKPGTL
660 670 680 690 700
TNDFFVNLLQ MGNTWKATDE TSETFEATDA SGQVKWTGTR FDLVFGSNSE
710 720 730
LRAVAEVYAS DDAKEKFVRD FVAAWDKVMN LDRFDLA
Length:737
Mass (Da):80,278
Last modified:April 17, 2007 - v1
Checksum:i5B4718AA45995ED2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03936.1.
RefSeqiWP_009943439.1. NZ_ABFV01000008.1.

Genome annotation databases

EnsemblBacteriaiCAM03936; CAM03936; SACE_4668.
KEGGisen:SACE_4668.
PATRICi23416806. VBISacEry28377_4697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03936.1.
RefSeqiWP_009943439.1. NZ_ABFV01000008.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405948.SeryN2_010100005622.

Protein family/group databases

PeroxiBasei5232. SerCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM03936; CAM03936; SACE_4668.
KEGGisen:SACE_4668.
PATRICi23416806. VBISacEry28377_4697.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SACEN
AccessioniPrimary (citable) accession number: A4FIR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.