A4FIQ1 (IOLG3_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase 3
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase 3
Short name=MI 2-dehydrogenase 3

Gene names

Name:	iolG3
Ordered Locus Names:	SACE_4657

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Inositol 2-dehydrogenase 3 HAMAP MF_01671		PRO_0000352592

Sequences

	Sequence		Length	Mass (Da)
	A4FIQ1 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 905B0B425EF22E3C	FASTA	338	36,130
	10 20 30 40 50 60 MTVRVGVIGT GMIGQDHIRR LTRVVTGAEI VAVTDIDADR AASVAGGVGA RTMPSGADVI 70 80 90 100 110 120 GSADVDAVLV TSWGPTHAEH VLAAIEAGKA VFCEKPLATE VEDCLRIVEA ESARGKRLVQ 130 140 150 160 170 180 VGFMRRYDAG YREMKELVDA GGIGTPLMAH CVHRNPTVPE TYHSAMAAQD TAVHEIDTLR 190 200 210 220 230 240 WLLDDEIVSA QVIRPRRTSK RFEHLQDPQI MLFETESGAR IDVEVFVNCQ YGYDIQCEVV 250 260 270 280 290 300 GESGTVRLPD PARTGLPSAG SVRAAITQDW KQRFADAFDA ELQSWVDSVA HGAAGGPSAW 310 320 330 DGYAATAICG ATVEALHSGQ VVPVALKDRP GLYGGNNQ

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM03926.1.
RefSeq	YP_001106851.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FIQ1.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FIQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4944476.
GenomeReviews	Gene locus SACE_4657 in contig AM420293_GR.
KEGG	sen:SACE_4657.
PATRIC	23416784. VBISacEry28377_4686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	HINRITN.
ProtClustDB	CLSK2786872.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_4657-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG3_SACEN

Accession

Primary (citable) accession number: A4FIQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program