A4FID1 (IOLG2_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase 2
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase 2
Short name=MI 2-dehydrogenase 2

Gene names

Name:	iolG2
Ordered Locus Names:	SACE_4537

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Inositol 2-dehydrogenase 2 HAMAP MF_01671		PRO_0000352591

Sequences

	Sequence		Length	Mass (Da)
	A4FID1 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: CE088D69EE28AB6F	FASTA	339	35,899
	10 20 30 40 50 60 MTMNIGVIGC GLMGADHIRT LTTAVSGARV AAVNDADEGR AAGAAAEAEG ARVHSDPFGL 70 80 90 100 110 120 IDDAEVDAVV VASADETHEE FALACVRAGK PVLCEKPLAT TSEACLRVVE AEMRGGRPLV 130 140 150 160 170 180 QVGFMRRFDP SYLEMKRVLD SGRIGRALML HSVHRNAGYP PALPDSALIT GTGVHDIDIA 190 200 210 220 230 240 RWLLGQEIVT ATAHTPRRSG LARPDFQDTR FLVLETENGV LVDVEIFVNA GYGYDVRGEL 250 260 270 280 290 300 VGELGSISLH PPATLTTRYE GLEGRPVARD FRPRFQDAYR NELQAWVTAG ASGEVRGATA 310 320 330 WDGYASAAVA EACLHSVATG STAPVEIAPQ PALYAPLAA

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM03806.1.
RefSeq	YP_001106731.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FID1.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FID1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4944356.
GenomeReviews	Gene locus SACE_4537 in contig AM420293_GR.
KEGG	sen:SACE_4537.
PATRIC	23416538. VBISacEry28377_4563.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	SADETHE.
PhylomeDB	A4FID1.
ProtClustDB	CLSK736006.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_4537-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG2_SACEN

Accession

Primary (citable) accession number: A4FID1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program