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A4FH01

- T23O_SACEN

UniProt

A4FH01 - T23O_SACEN

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Protein

Tryptophan 2,3-dioxygenase

Gene

kynA

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 2 heme groups per tetramer.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei123 – 1231HemeUniRule annotation
Metal bindingi239 – 2391Iron (heme axial ligand)UniRule annotation
Binding sitei253 – 2531SubstrateUniRule annotation

GO - Molecular functioni

  1. heme binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. tryptophan 2,3-dioxygenase activity Source: UniProtKB

GO - Biological processi

  1. protein homotetramerization Source: UniProtKB
  2. tryptophan catabolic process to kynurenine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Tryptophan catabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Short name:
TOUniRule annotation
Short name:
TRPOUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:kynAUniRule annotation
Ordered Locus Names:SACE_4055
OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
ProteomesiUP000006728: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Tryptophan 2,3-dioxygenasePRO_0000360132Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SACE_4055.

Structurei

3D structure databases

ProteinModelPortaliA4FH01.
SMRiA4FH01. Positions 22-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 275Substrate bindingUniRule annotation
Regioni50 – 545Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3483.
HOGENOMiHOG000221583.
KOiK00453.
OMAiFPELWQV.
OrthoDBiEOG6WMHXR.

Family and domain databases

HAMAPiMF_01972. T23O.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FH01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHGNSRPLE KDVVRDLRRE LSYGQYLRLD RLLDAQHPVS EPEHHDELLF
60 70 80 90 100
IIQHQTVELW LKLILHELRT AREHLARDEL KPALKQLARV KHVQHTLTEQ
110 120 130 140 150
WSVLATLTPA EYVEFRGFLG RSSGFQSYQY RAIELILGNK NAEMLEVFAH
160 170 180 190 200
DEFAHELLNG LLKEPSVYDE FVRLLHRRGH DVPAAFLQRD VSLPHTFTPE
210 220 230 240 250
LVPLFRGIYE TAAENWDAYE ACEELVDLEE NFQFWRFRHL KTVERTIGLK
260 270 280
HGTGGSSGVS FLRRALELTF FPELYAVRTE I
Length:281
Mass (Da):32,858
Last modified:April 17, 2007 - v1
Checksum:i46D47E07ABE1CE8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03326.1.
RefSeqiYP_001106251.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM03326; CAM03326; SACE_4055.
GeneIDi4943876.
KEGGisen:SACE_4055.
PATRICi23415556. VBISacEry28377_4072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03326.1 .
RefSeqi YP_001106251.1. NC_009142.1.

3D structure databases

ProteinModelPortali A4FH01.
SMRi A4FH01. Positions 22-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405948.SACE_4055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM03326 ; CAM03326 ; SACE_4055 .
GeneIDi 4943876.
KEGGi sen:SACE_4055.
PATRICi 23415556. VBISacEry28377_4072.

Phylogenomic databases

eggNOGi COG3483.
HOGENOMi HOG000221583.
KOi K00453.
OMAi FPELWQV.
OrthoDBi EOG6WMHXR.

Enzyme and pathway databases

UniPathwayi UPA00333 ; UER00453 .

Family and domain databases

HAMAPi MF_01972. T23O.
InterProi IPR004981. Trp_2_3_dOase.
[Graphical view ]
PANTHERi PTHR10138. PTHR10138. 1 hit.
Pfami PF03301. Trp_dioxygenase. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 23338.

Entry informationi

Entry nameiT23O_SACEN
AccessioniPrimary (citable) accession number: A4FH01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3