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Protein

Tryptophan 2,3-dioxygenase

Gene

kynA

Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 2 heme groups per tetramer.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112SubstrateUniRule annotation1
Binding sitei116SubstrateUniRule annotation1
Binding sitei123HemeUniRule annotation1
Metal bindingi239Iron (heme axial ligand)UniRule annotation1
Binding sitei253SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Tryptophan catabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Short name:
TOUniRule annotation
Short name:
TRPOUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:kynAUniRule annotation
Ordered Locus Names:SACE_4055
OrganismiSaccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
Proteomesi
  • UP000006728 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003601321 – 281Tryptophan 2,3-dioxygenaseAdd BLAST281

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SeryN2_010100017951.

Structurei

3D structure databases

ProteinModelPortaliA4FH01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 27Substrate bindingUniRule annotation5
Regioni50 – 54Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HJ8. Bacteria.
COG3483. LUCA.
HOGENOMiHOG000221583.
KOiK00453.
OMAiFITIHQV.
OrthoDBiPOG091H0DJ4.

Family and domain databases

HAMAPiMF_01972. T23O. 1 hit.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FH01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGNSRPLE KDVVRDLRRE LSYGQYLRLD RLLDAQHPVS EPEHHDELLF
60 70 80 90 100
IIQHQTVELW LKLILHELRT AREHLARDEL KPALKQLARV KHVQHTLTEQ
110 120 130 140 150
WSVLATLTPA EYVEFRGFLG RSSGFQSYQY RAIELILGNK NAEMLEVFAH
160 170 180 190 200
DEFAHELLNG LLKEPSVYDE FVRLLHRRGH DVPAAFLQRD VSLPHTFTPE
210 220 230 240 250
LVPLFRGIYE TAAENWDAYE ACEELVDLEE NFQFWRFRHL KTVERTIGLK
260 270 280
HGTGGSSGVS FLRRALELTF FPELYAVRTE I
Length:281
Mass (Da):32,858
Last modified:April 17, 2007 - v1
Checksum:i46D47E07ABE1CE8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03326.1.

Genome annotation databases

EnsemblBacteriaiCAM03326; CAM03326; SACE_4055.
KEGGisen:SACE_4055.
PATRICi23415556. VBISacEry28377_4072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM03326.1.

3D structure databases

ProteinModelPortaliA4FH01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405948.SeryN2_010100017951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM03326; CAM03326; SACE_4055.
KEGGisen:SACE_4055.
PATRICi23415556. VBISacEry28377_4072.

Phylogenomic databases

eggNOGiENOG4105HJ8. Bacteria.
COG3483. LUCA.
HOGENOMiHOG000221583.
KOiK00453.
OMAiFITIHQV.
OrthoDBiPOG091H0DJ4.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453.

Family and domain databases

HAMAPiMF_01972. T23O. 1 hit.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT23O_SACEN
AccessioniPrimary (citable) accession number: A4FH01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: October 5, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.