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A4FH01

- T23O_SACEN

UniProt

A4FH01 - T23O_SACEN

Protein

Tryptophan 2,3-dioxygenase

Gene

kynA

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

    Catalytic activityi

    L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

    Cofactori

    Binds 2 heme groups per tetramer.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei112 – 1121SubstrateUniRule annotation
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei123 – 1231HemeUniRule annotation
    Metal bindingi239 – 2391Iron (heme axial ligand)UniRule annotation
    Binding sitei253 – 2531SubstrateUniRule annotation

    GO - Molecular functioni

    1. heme binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. tryptophan 2,3-dioxygenase activity Source: UniProtKB

    GO - Biological processi

    1. protein homotetramerization Source: UniProtKB
    2. tryptophan catabolic process to kynurenine Source: UniProtKB

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Tryptophan catabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00333; UER00453.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
    Short name:
    TDOUniRule annotation
    Alternative name(s):
    Tryptamin 2,3-dioxygenaseUniRule annotation
    Tryptophan oxygenaseUniRule annotation
    Short name:
    TOUniRule annotation
    Short name:
    TRPOUniRule annotation
    Tryptophan pyrrolaseUniRule annotation
    TryptophanaseUniRule annotation
    Gene namesi
    Name:kynAUniRule annotation
    Ordered Locus Names:SACE_4055
    OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
    Taxonomic identifieri405948 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
    ProteomesiUP000006728: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Tryptophan 2,3-dioxygenasePRO_0000360132Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405948.SACE_4055.

    Structurei

    3D structure databases

    ProteinModelPortaliA4FH01.
    SMRiA4FH01. Positions 22-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 275Substrate bindingUniRule annotation
    Regioni50 – 545Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3483.
    HOGENOMiHOG000221583.
    KOiK00453.
    OMAiFPELWQV.
    OrthoDBiEOG6WMHXR.

    Family and domain databases

    HAMAPiMF_01972. T23O.
    InterProiIPR004981. Trp_2_3_dOase.
    [Graphical view]
    PANTHERiPTHR10138. PTHR10138. 1 hit.
    PfamiPF03301. Trp_dioxygenase. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FH01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHGNSRPLE KDVVRDLRRE LSYGQYLRLD RLLDAQHPVS EPEHHDELLF    50
    IIQHQTVELW LKLILHELRT AREHLARDEL KPALKQLARV KHVQHTLTEQ 100
    WSVLATLTPA EYVEFRGFLG RSSGFQSYQY RAIELILGNK NAEMLEVFAH 150
    DEFAHELLNG LLKEPSVYDE FVRLLHRRGH DVPAAFLQRD VSLPHTFTPE 200
    LVPLFRGIYE TAAENWDAYE ACEELVDLEE NFQFWRFRHL KTVERTIGLK 250
    HGTGGSSGVS FLRRALELTF FPELYAVRTE I 281
    Length:281
    Mass (Da):32,858
    Last modified:April 17, 2007 - v1
    Checksum:i46D47E07ABE1CE8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM03326.1.
    RefSeqiYP_001106251.1. NC_009142.1.

    Genome annotation databases

    EnsemblBacteriaiCAM03326; CAM03326; SACE_4055.
    GeneIDi4943876.
    KEGGisen:SACE_4055.
    PATRICi23415556. VBISacEry28377_4072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM03326.1 .
    RefSeqi YP_001106251.1. NC_009142.1.

    3D structure databases

    ProteinModelPortali A4FH01.
    SMRi A4FH01. Positions 22-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405948.SACE_4055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM03326 ; CAM03326 ; SACE_4055 .
    GeneIDi 4943876.
    KEGGi sen:SACE_4055.
    PATRICi 23415556. VBISacEry28377_4072.

    Phylogenomic databases

    eggNOGi COG3483.
    HOGENOMi HOG000221583.
    KOi K00453.
    OMAi FPELWQV.
    OrthoDBi EOG6WMHXR.

    Enzyme and pathway databases

    UniPathwayi UPA00333 ; UER00453 .

    Family and domain databases

    HAMAPi MF_01972. T23O.
    InterProi IPR004981. Trp_2_3_dOase.
    [Graphical view ]
    PANTHERi PTHR10138. PTHR10138. 1 hit.
    Pfami PF03301. Trp_dioxygenase. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
      Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
      Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL 23338.

    Entry informationi

    Entry nameiT23O_SACEN
    AccessioniPrimary (citable) accession number: A4FH01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3