Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4FH01 (T23O_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 2,3-dioxygenase

Short name=TDO
EC=1.13.11.11
Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase
Gene names
Name:kynA
Ordered Locus Names:SACE_4055
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity. HAMAP-Rule MF_01972

Catalytic activity

L-tryptophan + O2 = N-formyl-L-kynurenine. HAMAP-Rule MF_01972

Cofactor

Binds 2 heme groups per tetramer By similarity. HAMAP-Rule MF_01972

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. HAMAP-Rule MF_01972

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01972

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Tryptophan 2,3-dioxygenase HAMAP-Rule MF_01972
PRO_0000360132

Regions

Region23 – 275Substrate binding By similarity
Region50 – 545Substrate binding By similarity

Sites

Metal binding2391Iron (heme axial ligand) By similarity
Binding site1121Substrate By similarity
Binding site1161Substrate By similarity
Binding site1231Heme By similarity
Binding site2531Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A4FH01 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 46D47E07ABE1CE8E

FASTA28132,858
        10         20         30         40         50         60 
MVHGNSRPLE KDVVRDLRRE LSYGQYLRLD RLLDAQHPVS EPEHHDELLF IIQHQTVELW 

        70         80         90        100        110        120 
LKLILHELRT AREHLARDEL KPALKQLARV KHVQHTLTEQ WSVLATLTPA EYVEFRGFLG 

       130        140        150        160        170        180 
RSSGFQSYQY RAIELILGNK NAEMLEVFAH DEFAHELLNG LLKEPSVYDE FVRLLHRRGH 

       190        200        210        220        230        240 
DVPAAFLQRD VSLPHTFTPE LVPLFRGIYE TAAENWDAYE ACEELVDLEE NFQFWRFRHL 

       250        260        270        280 
KTVERTIGLK HGTGGSSGVS FLRRALELTF FPELYAVRTE I 

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM420293 Genomic DNA. Translation: CAM03326.1.
RefSeqYP_001106251.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4FH01.
SMRA4FH01. Positions 22-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405948.SACE_4055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM03326; CAM03326; SACE_4055.
GeneID4943876.
KEGGsen:SACE_4055.
PATRIC23415556. VBISacEry28377_4072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3483.
HOGENOMHOG000221583.
KOK00453.
OMAMLKPHAH.
OrthoDBEOG6WMHXR.

Enzyme and pathway databases

UniPathwayUPA00333; UER00453.

Family and domain databases

HAMAPMF_01972. T23O.
InterProIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERPTHR10138. PTHR10138. 1 hit.
PfamPF03301. Trp_dioxygenase. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT23O_SACEN
AccessionPrimary (citable) accession number: A4FH01
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 17, 2007
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways