A4FFN9 (UPPP_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA
Ordered Locus Names:	SACE_3590

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora › Saccharopolyspora erythraea

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290759
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A4FFN9 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: B90908271733F971	FASTA	273	29,304
	10 20 30 40 50 60 MQAMVLAVVQ GLTEFLPISS SGHLSIVSKL FFGSDAGASF TAVTQIGTEL AVVIYFAGDI 70 80 90 100 110 120 VRLVVTWFRG LVNAEVRRTQ DYRLAWYVIV GSLPIGVLGF LFQDYIRGAL RSLWITGAML 130 140 150 160 170 180 ILFGILMGLA ERFGAQRRGH DKLTMRDGVL MGSAQALALI PGVSRSGGTI TAGLSLGLDR 190 200 210 220 230 240 PTAVRFSFLL AIPAVFAAGV SEVSHVFEPS AHGLQPTGAQ MIVATVVAGV VGYAVIAWLL 250 260 270 RYVQKHSVYL FVWYRIVLGL VLFGLLGFGV IQP

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM02864.1.
RefSeq	YP_001105789.1. NC_009142.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	405948.SACE_3590.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAM02864; CAM02864; SACE_3590.
GeneID	4943414.
KEGG	sen:SACE_3590.
PATRIC	23414608. VBISacEry28377_3598.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HLAIFTA.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_SACEN

Accession

Primary (citable) accession number: A4FFN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program