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A4FFN9 (UPPP_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:SACE_3590
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290759

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4FFN9 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: B90908271733F971

FASTA27329,304
        10         20         30         40         50         60 
MQAMVLAVVQ GLTEFLPISS SGHLSIVSKL FFGSDAGASF TAVTQIGTEL AVVIYFAGDI 

        70         80         90        100        110        120 
VRLVVTWFRG LVNAEVRRTQ DYRLAWYVIV GSLPIGVLGF LFQDYIRGAL RSLWITGAML 

       130        140        150        160        170        180 
ILFGILMGLA ERFGAQRRGH DKLTMRDGVL MGSAQALALI PGVSRSGGTI TAGLSLGLDR 

       190        200        210        220        230        240 
PTAVRFSFLL AIPAVFAAGV SEVSHVFEPS AHGLQPTGAQ MIVATVVAGV VGYAVIAWLL 

       250        260        270 
RYVQKHSVYL FVWYRIVLGL VLFGLLGFGV IQP 

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM420293 Genomic DNA. Translation: CAM02864.1.
RefSeqYP_001105789.1. NC_009142.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405948.SACE_3590.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM02864; CAM02864; SACE_3590.
GeneID4943414.
KEGGsen:SACE_3590.
PATRIC23414608. VBISacEry28377_3598.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SACEN
AccessionPrimary (citable) accession number: A4FFN9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families