ID   A4FF44_SACEN            Unreviewed;       292 AA.
AC   A4FF44;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=ATP-dependent DNA ligase {ECO:0000313|EMBL:CAM02669.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:CAM02669.1};
DE   SubName: Full=Bifunctional non-homologous end joining protein LigD {ECO:0000313|EMBL:PFG96394.1};
GN   OrderedLocusNames=SACE_3394 {ECO:0000313|EMBL:CAM02669.1};
GN   ORFNames=A8924_3787 {ECO:0000313|EMBL:PFG96394.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02669.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM02669.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM02669.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG96394.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96394.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAM02669.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG96394.1; -; Genomic_DNA.
DR   RefSeq; WP_009949585.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FF44; -.
DR   STRING; 405948.SACE_3394; -.
DR   KEGG; sen:SACE_3394; -.
DR   eggNOG; COG3285; Bacteria.
DR   HOGENOM; CLU_008325_1_1_11; -.
DR   OrthoDB; 4296267at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd04864; LigD_Pol_like_1; 1.
DR   Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR   InterPro; IPR014145; LigD_pol_dom.
DR   NCBIfam; TIGR02778; ligD_pol; 1.
DR   PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR   PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR   Pfam; PF21686; LigD_Prim-Pol; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CAM02669.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN          31..283
FT                   /note="DNA ligase D polymerase"
FT                   /evidence="ECO:0000259|Pfam:PF21686"
SQ   SEQUENCE   292 AA;  32267 MW;  A61B8116DB7DA202 CRC64;
     MTANSETLDI DGRSVELSKG DKVMYPDDGF TKRDVVCHYR AVAPVMLPHV RGKPLTLRRF
     PDGIGSGGFF QKEASEHFPD WIRVVSVPQR GADDSVHHVV ADDAATLVYL ANQACLEFHV
     ALSTADDLEH PVLAVVDLDP PESTGIADLR SITKDMCDRF RDAGLDPFVQ ATGGKGFHVV
     APLDARRDFD DVRAHMAEIA DRAAQEDERL TTQQRKDKRG DRVFLDINRN AYGQTMIAPY
     SLRARPGAPA ATPIDLAEIS RATPNRHGLA NMTRRLARKA DPWARIDRHA AV
//