A4FDY3 (IOLG1_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase 1
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase 1
Short name=MI 2-dehydrogenase 1

Gene names

Name:	iolG1
Ordered Locus Names:	SACE_2980

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.
Sequence caution	The sequence CAM02258.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase 1 HAMAP MF_01671		PRO_0000352590

Sequences

	Sequence		Length	Mass (Da)
	A4FDY3 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 0C12AEBE8A6A7B95	FASTA	337	35,446
	10 20 30 40 50 60 MTVRVGVVGT GVMGADHVRT LTGGVAGARV VAVSDADQGR GRAVAAEAGD EVVFHADPVD 70 80 90 100 110 120 LIGDAGVDAV VVASPDHTHE ALATACVEAG KPVLCEKPLA ATAADCLRIV AHEVAKGRRL 130 140 150 160 170 180 VQAGYMRRFD PSYVDMKRAL DAGSIGDPVL VHCVHRNARA LHFFTPEMPF TSAAVHEFDV 190 200 210 220 230 240 VRWLLSSEIV RVTVHRTRSS SRAAARLADP RLLVLETAAG VTVDVEVFVN AQYGYDVRCE 250 260 270 280 290 300 LVGELGTVSL ALPSTTVVRA GGAEGVAVHA DFRTRFAEAY RLQLQAWVDA AARGEACGPS 310 320 330 AWDGYAATAV AEACLRAQED GTPVEVELAD KPALYGT

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM02258.1. Different initiation.
RefSeq	YP_001105183.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FDY3.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FDY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4942807.
GenomeReviews	Gene locus SACE_2980 in contig AM420293_GR.
KEGG	sen:SACE_2980.
PATRIC	23413364. VBISacEry28377_2977.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
ProtClustDB	CLSK736006.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_2980-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG1_SACEN

Accession

Primary (citable) accession number: A4FDY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	December 14, 2011
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program