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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyaseUniRule annotation (EC:4.3.1.1UniRule annotation)
Short name:
AspartaseUniRule annotation
Gene namesi
Name:aspAImported
Ordered Locus Names:SACE_2829Imported
OrganismiSaccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)Imported
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
Proteomesi
  • UP000006728 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi405948.SeryN2_010100036965.

Structurei

3D structure databases

ProteinModelPortaliA4FDI3.
SMRiA4FDI3. Positions 3-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 342331Lyase_1InterPro annotationAdd
BLAST
Domaini408 – 46053FumaraseC_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.
OMAiPEAMNQT.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4FDI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRTEHDLI GDREVPADAY YGVHTARAVD NFRITGTPIA TYPDLINALA
60 70 80 90 100
SVKEAAARAN HDLGLLDQRR AEAITAACAE IRAGKLHEQF VVDVIQGGAG
110 120 130 140 150
TSTNMNANEV IANRALEHLG HTRGDYHHLH PLEHVNLAQS TNDVYPTAIK
160 170 180 190 200
LALTTGLHRL HTAMGALAEA FHDKSVEFAD VLKMGRTQLQ DAVPMTLGQE
210 220 230 240 250
LKTYAIMLEE DRQRLTEATD LLLEINLGGT AIGTGINTHP DYAASACTHL
260 270 280 290 300
ARITAIPVRT ADNLVEATQD AGALVQLSGV LKRVAVKLSK TCNDLRLTSS
310 320 330 340 350
GPRAGLNEIN LPAVQAGSSI MPGKVNPVIP EVVNQVAFEV IGNDVTVTLA
360 370 380 390 400
AEAGQLQLNA FEPVIVHSAL KSLTHLTAAC DTLTTRCVTG ITANRTQLEH
410 420 430 440 450
TVRNSIGLIT ALSPYIGYTN ATTIAQQALT TDRSITDLVL DTGLITPDQL
460 470
ATLLQPEQLT QPRPLGNAPA N
Length:471
Mass (Da):50,254
Last modified:April 17, 2007 - v1
Checksum:i22284F91BE701A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM02108.1.
RefSeqiWP_011873844.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM02108; CAM02108; SACE_2829.
KEGGisen:SACE_2829.
PATRICi23413048. VBISacEry28377_2819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM02108.1.
RefSeqiWP_011873844.1. NC_009142.1.

3D structure databases

ProteinModelPortaliA4FDI3.
SMRiA4FDI3. Positions 3-454.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405948.SeryN2_010100036965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM02108; CAM02108; SACE_2829.
KEGGisen:SACE_2829.
PATRICi23413048. VBISacEry28377_2819.

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.
OMAiPEAMNQT.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338Imported.

Entry informationi

Entry nameiA4FDI3_SACEN
AccessioniPrimary (citable) accession number: A4FDI3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: March 16, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.