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A4FBY2

- PSA_SACEN

UniProt

A4FBY2 - PSA_SACEN

Protein

Proteasome subunit alpha

Gene

prcA

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.UniRule annotation

    Enzyme regulationi

    The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    UniPathwayiUPA00997.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
    Alternative name(s):
    20S proteasome alpha subunitUniRule annotation
    Proteasome core protein PrcAUniRule annotation
    Gene namesi
    Name:prcAUniRule annotation
    Ordered Locus Names:SACE_2252
    OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
    Taxonomic identifieri405948 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
    ProteomesiUP000006728: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Proteasome subunit alphaPRO_0000397171Add
    BLAST

    Interactioni

    Subunit structurei

    The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

    Protein-protein interaction databases

    STRINGi405948.SACE_2252.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000245319.
    KOiK03432.
    OMAiGRYNEFE.
    OrthoDBiEOG6NKQZG.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00289_B. Proteasome_A_B.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR022296. Proteasome_asu_bac.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
    PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4FBY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMPFYTSPE QLMRERSELA RKGIARGRSV VVLKYAGGVL FVAENPSTTL    50
    HKVSEIYDRI GFAAVGRYSE FESLRVAGVR IADVRGYSYD RRDVTGRALA 100
    NTYAQHLGAI FTEQIKPFEV EICVAEVGQT ADNDQLYRLT YDGSIVDEPQ 150
    YVVMGGQADT ITTTLKDSFS DGLELAEAAG LAIRALSSGG EGTRELGVGQ 200
    LEVAVLDRAR PNRTFRRITG AALKALLPSQ EESGSTDGEA SGDAGDDKKT 250
    GDDKKS 256
    Length:256
    Mass (Da):27,685
    Last modified:April 17, 2007 - v1
    Checksum:i9A02ADAE4EEB42C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM01557.1.
    RefSeqiYP_001104482.1. NC_009142.1.

    Genome annotation databases

    EnsemblBacteriaiCAM01557; CAM01557; SACE_2252.
    GeneIDi4942105.
    KEGGisen:SACE_2252.
    PATRICi23411932. VBISacEry28377_2261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM420293 Genomic DNA. Translation: CAM01557.1 .
    RefSeqi YP_001104482.1. NC_009142.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405948.SACE_2252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM01557 ; CAM01557 ; SACE_2252 .
    GeneIDi 4942105.
    KEGGi sen:SACE_2252.
    PATRICi 23411932. VBISacEry28377_2261.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000245319.
    KOi K03432.
    OMAi GRYNEFE.
    OrthoDBi EOG6NKQZG.

    Enzyme and pathway databases

    UniPathwayi UPA00997 .

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00289_B. Proteasome_A_B.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR022296. Proteasome_asu_bac.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR03691. 20S_bact_alpha. 1 hit.
    PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
      Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
      Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL 23338.

    Entry informationi

    Entry nameiPSA_SACEN
    AccessioniPrimary (citable) accession number: A4FBY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3