A4FBW7 (HIS2_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	SACE_2237

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000063382

Sequences

	Sequence		Length	Mass (Da)
	A4FBW7 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: DD7F5AB8ED30325A	FASTA	87	9,746
	10 20 30 40 50 60 MKTFDELFAE LQERARTRPE GSATVAALDA GVHAQGKKVI EEAGEVWIAA EYESDEALAE 70 80 EISQLLYRLQ VVMLGRGLSL EDVYRYL

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM01542.1.
RefSeq	YP_001104467.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4FBW7.
SMR	A4FBW7. Positions 1-87.
ModBase	Search...
Protein-protein interaction databases
STRING	A4FBW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4942090.
GenomeReviews	Gene locus SACE_2237 in contig AM420293_GR.
KEGG	sen:SACE_2237.
PATRIC	23411900. VBISacEry28377_2245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0140.
HOGENOM	HBG646527.
OMA	VWMAAEY.
ProtClustDB	PRK00400.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_2237-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. [Graphical view]
KO	K01523.
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_SACEN

Accession

Primary (citable) accession number: A4FBW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program