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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:SACE_2113
OrganismiSaccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
Proteomesi
  • UP000006728 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201501 – 309Methionyl-tRNA formyltransferaseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi405948.SeryN2_010100003832

Structurei

3D structure databases

ProteinModelPortaliA4FBJ4
SMRiA4FBJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A4FBJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFAGTPE PAVPSLRALI ESANHEVAAV VTRPDAPAGR GRKLMRSPVG
60 70 80 90 100
ALADEHGIEV LTPAKASDPE FLARLRELEP ECCPVVAYGA LLRQTALDIP
110 120 130 140 150
EHGWVNLHFS LLPAWRGAAP VQAAIKHGDQ ITGASTFRLV PELDAGPVYG
160 170 180 190 200
VVTEEVRDTD TSGVLLERLS VSGAKLLVAT LDGIADGTLR AEEQPADGVS
210 220 230 240 250
YAPKVEVEDA RVDFTAPARA VDRLVRSVTP DPGAWASFRD ERLKLGPVSI
260 270 280 290 300
VDEDLGLAPG EIRVERRRVL AGTGSAPVAL GEVQAQGKKR MAATDWARGS

RIEQGERLK
Length:309
Mass (Da):32,953
Last modified:April 17, 2007 - v1
Checksum:i930E2CC6F5BED533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA Translation: CAM01419.1
RefSeqiWP_009943007.1, NZ_PDBV01000001.1

Genome annotation databases

EnsemblBacteriaiCAM01419; CAM01419; SACE_2113
KEGGisen:SACE_2113

Similar proteinsi

Entry informationi

Entry nameiFMT_SACEN
AccessioniPrimary (citable) accession number: A4FBJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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