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A4FBG2 (A4FBG2_SACEN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:SACE_2080
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
A4FBG2 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: C84CCAE6D664C0B1

FASTA43245,636
        10         20         30         40         50         60 
MSRVLLKDVR PYGEGEPVDL LVDGGLIAEI GADLRVDADE IVHAGGAVAL PGFVDLHTHL 

        70         80         90        100        110        120 
REPGREDTET IETGSVAAAL GGYTAVFAMA NTDPVADNAV VVEHVWRRGR EVGLVDVHPV 

       130        140        150        160        170        180 
GAVTVGLAGE KLAELGTMAR SSAGVRLFSD DGHCVHDPLV MRRALEYTRA LGGVVAQHAE 

       190        200        210        220        230        240 
EPRLTVGAQA HEGANAAKLG LEGWPAPAEE AIVARDCLLS GHTGGTLHVC HVSTAGTAEI 

       250        260        270        280        290        300 
LRWWKSQERR GRVSAEVTPH HLLLTDDLLA GYDPLYKVNP PLRTDDDVRA LRQALADGTV 

       310        320        330        340        350        360 
DCVATDHAPH ADQDKTCEWS AARPGMLGLQ TALGVVVATM VETGLLDWRG VARVMSERPA 

       370        380        390        400        410        420 
EIAGLADQGR PVAAGEPANL VLVDGGARWT VRGAELASIA ENSPYEGMEL PGRVVATMLR 

       430 
GTITAVEGKV RR

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References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM420293 Genomic DNA. Translation: CAM01387.1.
RefSeqYP_001104312.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4FBG2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4FBG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4941935.
GenomeReviewsGene locus SACE_2080 in contig AM420293_GR.
KEGGsen:SACE_2080.
PATRIC23411584. VBISacEry28377_2087.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
HOGENOMHBG724623.
OMACDVHPVG.
ProtClustDBPRK09357.

Enzyme and pathway databases

BioCycSERY405948:SACE_2080-MONOMER.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4FBG2_SACEN
AccessionPrimary (citable) accession number: A4FBG2
Entry history
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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