Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4FAF8 (A4FAF8_SACEN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862
Gene names
Name:metF EMBL CAM01033.1
Ordered Locus Names:SACE_1715
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862

Cofactor

FAD By similarity. RuleBase RU003862

Pathway

One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255

Sequence similarities

Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Sequences

Sequence LengthMass (Da)Tools
A4FAF8 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 8137F250E0E62DF1

FASTA29432,126
        10         20         30         40         50         60 
MTAVVDRLAG GRTGFSVEFF PPRDDEEERI LWRAVRELEP LDPAFVSVTY GAGGSSRDRT 

        70         80         90        100        110        120 
IRTTGRIAQE TTLTPVAHLT AVNHSVAELR NVIGWYAAVG VCNVLAIRGD PPGDPNGEWV 

       130        140        150        160        170        180 
THPEGLTYAE ELVRLVRELG DFCVGVAAFP HGHPRSTCLD TDVEHLVRKI QTGAEFAVAQ 

       190        200        210        220        230        240 
LFLEPEHFLR LRDRMSERGC DVPLLPGIMP ITTPRVLRKF GELSGAPVPP AVLERLEPLA 

       250        260        270        280        290 
DDAAAFRAEG VVLATELCER LIAEGVPALH FYTLNRSKAT REVVSNLGLL PARA

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM420293 Genomic DNA. Translation: CAM01033.1.
RefSeqYP_001103958.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4FAF8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4FAF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4941577.
GenomeReviewsGene locus SACE_1715 in contig AM420293_GR.
KEGGsen:SACE_1715.
PATRIC23410842. VBISacEry28377_1719.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0685.
HOGENOMHBG649727.
OMAITQMFFD.
PhylomeDBA4FAF8.
ProtClustDBCLSK735936.

Enzyme and pathway databases

BioCycSERY405948:SACE_1715-MONOMER.

Family and domain databases

InterProIPR003171. Mehydrof_redctse.
IPR004620. MTHF_reductase_bac.
[Graphical view]
KOK00297.
PfamPF02219. MTHFR. 1 hit.
[Graphical view]
TIGRFAMsTIGR00676. Fadh2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4FAF8_SACEN
AccessionPrimary (citable) accession number: A4FAF8
Entry history
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info