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A4FAB4

- GLSA_SACEN

UniProt

A4FAB4 - GLSA_SACEN

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Protein
Glutaminase
Gene
glsA, SACE_1670
Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei239 – 2391Substrate By similarity
Binding sitei257 – 2571Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:SACE_1670
OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora
ProteomesiUP000006728: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303GlutaminaseUniRule annotation
PRO_1000048353Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SACE_1670.

Structurei

3D structure databases

ProteinModelPortaliA4FAB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FAB4-1 [UniParc]FASTAAdd to Basket

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MEMSSLLERI TDQIAPLRGS GEVADYIPAL ARADPDRFGI AVAEVDGGVH    50
GAGDWEAPFS MQSISKVFTL AMVLAEGDDT LWRRVGREPS GNPFNSLVQL 100
EHERGIPRNP FINAGALAVT DQLISLTGDA VGNLLEFLRT ESANPALPID 150
DEVAISERAH ADRNLALAHF MASYGNMRNP VDDVIDQYVR QCSIAMSCHD 200
LAEAGLLLAR HGVRRDGSGY LSRSQAKRIN AIMLTCGTYD AAGEFAYHVG 250
IPGKSGVGGG ILAIVPGRCA VAVWSPGLDR RGNSVAGVAA LDHFTTLTGW 300
SVF 303
Length:303
Mass (Da):32,299
Last modified:April 17, 2007 - v1
Checksum:iC3C174BCB805BB7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM00989.1.
RefSeqiYP_001103914.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM00989; CAM00989; SACE_1670.
GeneIDi4941533.
KEGGisen:SACE_1670.
PATRICi23410750. VBISacEry28377_1673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM420293 Genomic DNA. Translation: CAM00989.1 .
RefSeqi YP_001103914.1. NC_009142.1.

3D structure databases

ProteinModelPortali A4FAB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405948.SACE_1670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM00989 ; CAM00989 ; SACE_1670 .
GeneIDi 4941533.
KEGGi sen:SACE_1670.
PATRICi 23410750. VBISacEry28377_1673.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 23338.

Entry informationi

Entry nameiGLSA_SACEN
AccessioniPrimary (citable) accession number: A4FAB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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