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Protein

Glutaminase

Gene

glsA

Organism
Saccharopolyspora erythraea (strain NRRL 23338)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631SubstrateUniRule annotation
Binding sitei113 – 1131SubstrateUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Binding sitei188 – 1881SubstrateUniRule annotation
Binding sitei239 – 2391SubstrateUniRule annotation
Binding sitei257 – 2571Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:SACE_1670
OrganismiSaccharopolyspora erythraea (strain NRRL 23338)
Taxonomic identifieri405948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharopolyspora
ProteomesiUP000006728 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303GlutaminasePRO_1000048353Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405948.SeryN2_010100007392.

Structurei

3D structure databases

ProteinModelPortaliA4FAB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVCEEVYE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4FAB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMSSLLERI TDQIAPLRGS GEVADYIPAL ARADPDRFGI AVAEVDGGVH
60 70 80 90 100
GAGDWEAPFS MQSISKVFTL AMVLAEGDDT LWRRVGREPS GNPFNSLVQL
110 120 130 140 150
EHERGIPRNP FINAGALAVT DQLISLTGDA VGNLLEFLRT ESANPALPID
160 170 180 190 200
DEVAISERAH ADRNLALAHF MASYGNMRNP VDDVIDQYVR QCSIAMSCHD
210 220 230 240 250
LAEAGLLLAR HGVRRDGSGY LSRSQAKRIN AIMLTCGTYD AAGEFAYHVG
260 270 280 290 300
IPGKSGVGGG ILAIVPGRCA VAVWSPGLDR RGNSVAGVAA LDHFTTLTGW

SVF
Length:303
Mass (Da):32,299
Last modified:April 17, 2007 - v1
Checksum:iC3C174BCB805BB7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM00989.1.
RefSeqiWP_009943877.1. NZ_ABFV01000010.1.
YP_001103914.1. NC_009142.1.

Genome annotation databases

EnsemblBacteriaiCAM00989; CAM00989; SACE_1670.
KEGGisen:SACE_1670.
PATRICi23410750. VBISacEry28377_1673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM420293 Genomic DNA. Translation: CAM00989.1.
RefSeqiWP_009943877.1. NZ_ABFV01000010.1.
YP_001103914.1. NC_009142.1.

3D structure databases

ProteinModelPortaliA4FAB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405948.SeryN2_010100007392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM00989; CAM00989; SACE_1670.
KEGGisen:SACE_1670.
PATRICi23410750. VBISacEry28377_1673.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVCEEVYE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
    Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
    Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 23338.

Entry informationi

Entry nameiGLSA_SACEN
AccessioniPrimary (citable) accession number: A4FAB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.