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A4FAB4 (GLSA_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:SACE_1670
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Glutaminase HAMAP-Rule MF_00313
PRO_1000048353

Sites

Binding site631Substrate By similarity
Binding site1131Substrate By similarity
Binding site1571Substrate By similarity
Binding site1641Substrate By similarity
Binding site1881Substrate By similarity
Binding site2391Substrate By similarity
Binding site2571Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A4FAB4 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: C3C174BCB805BB7E

FASTA30332,299
        10         20         30         40         50         60 
MEMSSLLERI TDQIAPLRGS GEVADYIPAL ARADPDRFGI AVAEVDGGVH GAGDWEAPFS 

        70         80         90        100        110        120 
MQSISKVFTL AMVLAEGDDT LWRRVGREPS GNPFNSLVQL EHERGIPRNP FINAGALAVT 

       130        140        150        160        170        180 
DQLISLTGDA VGNLLEFLRT ESANPALPID DEVAISERAH ADRNLALAHF MASYGNMRNP 

       190        200        210        220        230        240 
VDDVIDQYVR QCSIAMSCHD LAEAGLLLAR HGVRRDGSGY LSRSQAKRIN AIMLTCGTYD 

       250        260        270        280        290        300 
AAGEFAYHVG IPGKSGVGGG ILAIVPGRCA VAVWSPGLDR RGNSVAGVAA LDHFTTLTGW 


SVF 

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM420293 Genomic DNA. Translation: CAM00989.1.
RefSeqYP_001103914.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4FAB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405948.SACE_1670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM00989; CAM00989; SACE_1670.
GeneID4941533.
KEGGsen:SACE_1670.
PATRIC23410750. VBISacEry28377_1673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAQRARRIN.
OrthoDBEOG6N94BK.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_SACEN
AccessionPrimary (citable) accession number: A4FAB4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families