ID   A4FAA7_SACEN            Unreviewed;       417 AA.
AC   A4FAA7;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=SACE_1663 {ECO:0000313|EMBL:CAM00982.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00982.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM00982.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
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DR   EMBL; AM420293; CAM00982.1; -; Genomic_DNA.
DR   RefSeq; WP_009943887.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FAA7; -.
DR   STRING; 405948.SACE_1663; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; sen:SACE_1663; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:CAM00982.1};
KW   Hydrolase {ECO:0000313|EMBL:CAM00982.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..417
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038521608"
FT   DOMAIN          78..383
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          109..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  43469 MW;  A782218C24A065B4 CRC64;
     MRTAAAVLAA AALGSACAGA PAAAPEEPKG AGNAASPVFA KAEGGGAAIA GTTIFRKGEG
     GYNCFRIPAI VRTQDRSTLL AFAEGRNNNC DDTGDIDVVL KRSTDDGRTW GGLEPVSDGA
     GDTRGNPVPV VDRGTGRISL LTTHNPGPEC NPGTKCTRTP YLQHSTDPKG TGWTAPKAQP
     QLKKADWSTW YATGPGHGLQ LTRPGDHQNR MLAGINFGGG GGLKGAGLVH SDDGGTTWQL
     GALDDRTGEK ITPQELSLLE TVDGRVYTAA RNQDNSGTET PTGNRADAVS TDAGASFSQD
     FAVVPELKGP VVQGSVVRLR AKTAGDPNNL VLFSGPYNTD PAMDHRRHTM RIRTSSDEGA
     TWQEGGTVID ATWAAYSDLV NLGGGWAGLL YEAGSPASED AHETIRYARF NESDLAR
//