A4F910 (MURI_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	SACE_1209

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Glutamate racemase HAMAP MF_00258		PRO_1000078570

Sequences

	Sequence		Length	Mass (Da)
	A4F910 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 93EE07A26C592654	FASTA	271	28,312
	10 20 30 40 50 60 MTHAPIGIFD SGVGGLTVAR AIMDQLPGEA LRYVGDTANA PYGPRPLADI RARTLAITDS 70 80 90 100 110 120 LVAEGVKMLV IACNSASAAC LRDARERYDV PVVEVVLPAV RRAVATTRNG RVGVIGTQAT 130 140 150 160 170 180 ITSRAYDDAF TAAPGVTLST AACPRFADFV ERGITSGRQV LGLAQAYLDP LQQADVDTLV 190 200 210 220 230 240 LGCTHYPLLT GVLQLAMGDH VTLVSSAEET AKDVLRVLTE HDLLAEADGE PAHEFRATGS 250 260 270 GESFAKLARR FLGPSLAADA IDPLAVSSSS A

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAM00535.1.
RefSeq	YP_001103460.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4F910.
ModBase	Search...
Protein-protein interaction databases
STRING	A4F910.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4941062.
GenomeReviews	Gene locus SACE_1209 in contig AM420293_GR.
KEGG	sen:SACE_1209.
PATRIC	23409788. VBISacEry28377_1207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0796.
HOGENOM	HBG645102.
OMA	PQEDTIY.
PhylomeDB	A4F910.
ProtClustDB	PRK00865.
Enzyme and pathway databases
BioCyc	SERY405948:SACE_1209-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_SACEN

Accession

Primary (citable) accession number: A4F910

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program