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A4F891 (FENR_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP+ reductase
EC=1.18.1.2
Gene names
Ordered Locus Names:SACE_0932
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_01685

Subunit structure

Homodimer By similarity. HAMAP MF_01685

Sequence similarities

Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionferredoxin-NADP+ reductase activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Ferredoxin--NADP reductase HAMAP MF_01685
PRO_0000364931

Sites

Binding site181FAD By similarity
Binding site371FAD By similarity
Binding site451FAD By similarity
Binding site501FAD By similarity
Binding site901FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1241FAD; via amide nitrogen By similarity
Binding site2831FAD By similarity
Binding site3241FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A4F891 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 8E9ECE76B8412EBE

FASTA32734,374
        10         20         30         40         50         60 
MTPVPGEVDL LVVGAGPTGL FAAYYAGFRG MSVAVVDALP EPGGQVTAMY PEKMIYDVAG 

        70         80         90        100        110        120 
FPEVRGRDLV DALVRQAAQY DPVYLLGRHA EKLSEVEGGL LVDVGERESV RAGAVLVTAG 

       130        140        150        160        170        180 
IGEFTPRPLP AADDWLGRGV VHFIPELGAH SGQDVVVVGG GDSAFDWALA LHPVARSVTL 

       190        200        210        220        230        240 
VHRRARFRAH AGLVDKVRGL GVPLITDAEV AEIRGDDAGP HEVELALAGD RRQVLPAQAV 

       250        260        270        280        290        300 
VAALGFTADL GPIESWGLEL EKRTIRVDST MRTSRERVYA AGDVAAYPGK VKLIATGFGE 

       310        320 
AATAVNNIAV ALNPEAHLFP GHSSNMG

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM420293 Genomic DNA. Translation: CAM00266.1.
RefSeqYP_001103191.1. NC_009142.1.

3D structure databases

ProteinModelPortalA4F891.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4F891.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4940790.
GenomeReviewsGene locus SACE_0932 in contig AM420293_GR.
KEGGsen:SACE_0932.
PATRIC23409240. VBISacEry28377_0936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0492.
HOGENOMHBG669726.
OMAYPNKQKL.
ProtClustDBCLSK947807.

Enzyme and pathway databases

BioCycSERY405948:SACE_0932-MONOMER.

Family and domain databases

HAMAPMF_01685. FENR2.
[Tree]
InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
KOK00384.
PANTHERPTHR22912:SF53. PTHR22912:SF53. 1 hit.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetSearch...

Entry information

Entry nameFENR_SACEN
AccessionPrimary (citable) accession number: A4F891
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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