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A4F743 (PSD_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:SACE_0521
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000026692
Chain203 – 23634Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000026693

Sites

Site202 – 2032Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2031Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
A4F743 [UniParc].

Last modified April 17, 2007. Version 1.
Checksum: 26C6ECC294309A58

FASTA23625,166
        10         20         30         40         50         60 
MSTEQEPKTS PLTHLVALAR DTVPPMHPAG RPFVLGAAVA TLLLRRRWRG AGVLGGILTA 

        70         80         90        100        110        120 
WCAWFFREPR RTAPTRDGIA VAPADGTVAH VEKAVPPAEL GLGAAPMTRV SVFLTIFDVH 

       130        140        150        160        170        180 
VQRVPLSGEV TKVSYRAGKF LSADLDKASE DNERNSMLIR GADGTEVAVV QIAGLVARRI 

       190        200        210        220        230 
VCSASEGDQV LAGHTYGLIR FGSRVDLYVP ADSRVLVEPG QRTIGGETVI AELARA

« Hide

References

[1]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed: 17369815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM420293 Genomic DNA. Translation: CAL99867.1.
RefSeqYP_001102793.1. NC_009142.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4F743.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4940387.
GenomeReviewsGene locus SACE_0521 in contig AM420293_GR.
KEGGsen:SACE_0521.
PATRIC23408422. VBISacEry28377_0531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBCLSK2535886.

Enzyme and pathway databases

BioCycSERY405948:SACE_0521-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_SACEN
AccessionPrimary (citable) accession number: A4F743
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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