A4F6K2 (A4F6K2_SACEN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III beta subunit EMBL CAL99676.1
EC=2.7.7.7 EMBL CAL99676.1

Gene names

Name:	dnaN EMBL CAL99676.1
Ordered Locus Names:	SACE_0327 EMBL CAL99676.1

Organism

Saccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP] EMBL CAL99676.1

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora › Saccharopolyspora erythraea

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity. SAAS SAAS022634
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS022634

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS022634
Cellular component	Cytoplasm SAAS SAAS022634
Molecular function	DNA-directed DNA polymerase SAAS SAAS022634 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	DNA polymerase III complex Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4F6K2 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 51285AEF90E99F05	FASTA	364	38,719
	10 20 30 40 50 60 MDLDVTAPTR ALAAAAADLV RLLPGRLLDP VLAGMVLTAT PQGLELAGTD RERGIRLSRR 70 80 90 100 110 120 ARTHAEGRIL VPARPLAETL RNLDSVEVRL VVEGAKLALR TRNARFALPL LDLAAHPGVR 130 140 150 160 170 180 AAPPRAGALD AALLPAVAVV AAATSRDDAL PVFTGVHVKQ RGERLVLAGT DRFRMAVATL 190 200 210 220 230 240 PWRPGTDDLD VLVPSGLLTE VAKQASGDEV MLRADADRVG LSWADAEVST TLLDAPFPDE 250 260 270 280 290 300 SRHLLPEVDC AVEVRADEVA GAVRRVSPYA GAHGAVVLDV GDAEVRVRAA DPQFGDAQEA 310 320 330 340 350 360 VKATVTGDRF SPAFQPRYLA DALQAFAGRT VRMGLRSGLR RSTVISDVDA PEADLRYVLM PKRI

References

[1]

"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338." Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NRRL 23338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM420293 Genomic DNA. Translation: CAL99676.1.
RefSeq	YP_001102602.1. NC_009142.1.
3D structure databases
ProteinModelPortal	A4F6K2.
ModBase	Search...
Protein-protein interaction databases
STRING	405948.SACE_0327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL99676; CAL99676; SACE_0327.
GeneID	4940194.
KEGG	sen:SACE_0327.
PATRIC	23408016. VBISacEry28377_0330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0592.
HOGENOM	HOG000071793.
KO	K02338.
OMA	QAGESSE.
ProtClustDB	CLSK2535836.
Family and domain databases
InterPro	IPR001001. DNA_polIII_beta. IPR022635. DNA_polIII_beta_C. IPR022637. DNA_polIII_beta_cen. IPR022634. DNA_polIII_beta_N. [Graphical view]
Pfam	PF00712. DNA_pol3_beta. 1 hit. PF02767. DNA_pol3_beta_2. 1 hit. PF02768. DNA_pol3_beta_3. 1 hit. [Graphical view]
SMART	SM00480. POL3Bc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00663. dnan. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4F6K2_SACEN

Accession

Primary (citable) accession number: A4F6K2

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)