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Protein

Mitochondrial import receptor subunit TOM40B

Gene

Tomm40l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:Tomm40lBy similarity
Synonyms:Tomm40bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1562006. Tomm40l.

Subcellular locationi

  • Mitochondrion outer membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Mitochondrial import receptor subunit TOM40BPRO_0000312687Add
BLAST

Proteomic databases

PaxDbiA4F267.
PeptideAtlasiA4F267.
PRIDEiA4F267.

Expressioni

Tissue specificityi

Widely expressed. Higher levels in heart, brain and liver, very low level in testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000003398.
GenevisibleiA4F267. RN.

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences.1 Publication

Protein-protein interaction databases

BioGridi258038. 1 interaction.
STRINGi10116.ENSRNOP00000004641.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 30828Required for mitochondrial targeting1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the Tom40 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiA4F267.
KOiK11518.
OMAiHLHAAFV.
OrthoDBiEOG091G0MNA.
PhylomeDBiA4F267.
TreeFamiTF106204.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4F267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTLGLAPM GTLPRWSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSALHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):34,049
Last modified:April 17, 2007 - v1
Checksum:iABD54E0E91673E18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB274732 mRNA. Translation: BAF49085.1.
RefSeqiNP_001076807.1. NM_001083338.1.
XP_006250309.1. XM_006250247.2.
UniGeneiRn.113744.

Genome annotation databases

EnsembliENSRNOT00000004641; ENSRNOP00000004641; ENSRNOG00000003398.
GeneIDi304971.
KEGGirno:304971.
UCSCiRGD:1562006. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB274732 mRNA. Translation: BAF49085.1.
RefSeqiNP_001076807.1. NM_001083338.1.
XP_006250309.1. XM_006250247.2.
UniGeneiRn.113744.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi258038. 1 interaction.
STRINGi10116.ENSRNOP00000004641.

Proteomic databases

PaxDbiA4F267.
PeptideAtlasiA4F267.
PRIDEiA4F267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004641; ENSRNOP00000004641; ENSRNOG00000003398.
GeneIDi304971.
KEGGirno:304971.
UCSCiRGD:1562006. rat.

Organism-specific databases

CTDi84134.
RGDi1562006. Tomm40l.

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiA4F267.
KOiK11518.
OMAiHLHAAFV.
OrthoDBiEOG091G0MNA.
PhylomeDBiA4F267.
TreeFamiTF106204.

Miscellaneous databases

PROiA4F267.

Gene expression databases

BgeeiENSRNOG00000003398.
GenevisibleiA4F267. RN.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM40L_RAT
AccessioniPrimary (citable) accession number: A4F267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.