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Protein

Mitochondrial import receptor subunit TOM40B

Gene

Tomm40l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.1 Publication

GO - Molecular functioni

  • mitochondrion targeting sequence binding Source: RGD
  • preprotein binding Source: RGD
  • protein transmembrane transporter activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:Tomm40lBy similarity
Synonyms:Tomm40bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1562006 Tomm40l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126871 – 308Mitochondrial import receptor subunit TOM40BAdd BLAST308

Proteomic databases

PaxDbiA4F267
PeptideAtlasiA4F267
PRIDEiA4F267

Expressioni

Tissue specificityi

Widely expressed. Higher levels in heart, brain and liver, very low level in testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000003398
GenevisibleiA4F267 RN

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences.1 Publication

GO - Molecular functioni

  • preprotein binding Source: RGD

Protein-protein interaction databases

BioGridi258038, 1 interactor
STRINGi10116.ENSRNOP00000004641

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 308Required for mitochondrial targeting1 PublicationAdd BLAST28

Sequence similaritiesi

Belongs to the Tom40 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiA4F267
KOiK11518
OMAiMINSRCI
OrthoDBiEOG091G0MNA
PhylomeDBiA4F267
TreeFamiTF106204

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4F267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTLGLAPM GTLPRWSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSALHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):34,049
Last modified:April 17, 2007 - v1
Checksum:iABD54E0E91673E18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB274732 mRNA Translation: BAF49085.1
RefSeqiNP_001076807.1, NM_001083338.1
XP_006250309.1, XM_006250247.3
UniGeneiRn.113744

Genome annotation databases

EnsembliENSRNOT00000004641; ENSRNOP00000004641; ENSRNOG00000003398
GeneIDi304971
KEGGirno:304971
UCSCiRGD:1562006 rat

Similar proteinsi

Entry informationi

Entry nameiTM40L_RAT
AccessioniPrimary (citable) accession number: A4F267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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