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A4F255

- A4F255_HUMAN

UniProt

A4F255 - A4F255_HUMAN

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Protein
Submitted name:

Immunoblobulin G1 Fab heavy chain variable region

Gene

VHCH1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Immunoblobulin G1 Fab heavy chain variable regionImported
Gene namesi
Name:VHCH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiA4F255.
PRIDEiA4F255.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QADX-ray3.30D/H33-228[»]
ProteinModelPortaliA4F255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG313034.
HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A4F255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LEESGGGVVQ PGKSLRLSCT ASGFIFSDFG MHWVRQAPGK GLESVATIWS
60 70 80 90 100
DGSNEKYADS VTGRFAISRD NSKNMLYLHM DNLRAEDTAV YYCARDADMI
110 120 130 140 150
TFARILDPPF HKGMDVWGQG TTVIVSSAST KGPSVFPLAP SSKSTSGGTA
160 170 180 190 200
ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS
210 220 230
SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTS
Length:234
Mass (Da):24,904
Last modified:April 17, 2007 - v1
Checksum:i5B93F757FF3FFADA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei234 – 2341Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB274410 mRNA. Translation: BAF48997.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB274410 mRNA. Translation: BAF48997.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QAD X-ray 3.30 D/H 33-228 [» ]
ProteinModelPortali A4F255.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

Proteomic databases

PaxDbi A4F255.
PRIDEi A4F255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG313034.
HOVERGENi HBG005814.

Miscellaneous databases

NextBioi 35461721.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4."
    Huang C.C., Lam S.N., Acharya P., Tang M., Xiang S.H., Hussan S.S., Stanfield R.L., Robinson J., Sodroski J., Wilson I.A., Wyatt R., Bewley C.A., Kwong P.D.
    Science 317:1930-1934(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 33-228, ACTIVE SITE.
  2. "Identification of a human monoclonal Fab with neutralizing activity against H3N2 influenza A strain from a newly constructed human Fab library."
    Shibuya T., Yamashiro T., Masaike Y., Ohuchi M., Uechi G., Nishizono A.
    Microbiol. Immunol. 52:162-170(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA4F255_HUMAN
AccessioniPrimary (citable) accession number: A4F255
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3