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A4F255

- A4F255_HUMAN

UniProt

A4F255 - A4F255_HUMAN

Protein
Submitted name:

Immunoblobulin G1 Fab heavy chain variable region

Gene

VHCH1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Immunoblobulin G1 Fab heavy chain variable regionImported
    Gene namesi
    Name:VHCH1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Proteomic databases

    PaxDbiA4F255.
    PRIDEiA4F255.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QADX-ray3.30D/H33-228[»]
    ProteinModelPortaliA4F255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG313034.
    HOVERGENiHBG005814.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A4F255-1 [UniParc]FASTAAdd to Basket

    « Hide

    LEESGGGVVQ PGKSLRLSCT ASGFIFSDFG MHWVRQAPGK GLESVATIWS    50
    DGSNEKYADS VTGRFAISRD NSKNMLYLHM DNLRAEDTAV YYCARDADMI 100
    TFARILDPPF HKGMDVWGQG TTVIVSSAST KGPSVFPLAP SSKSTSGGTA 150
    ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS 200
    SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTS 234
    Length:234
    Mass (Da):24,904
    Last modified:April 17, 2007 - v1
    Checksum:i5B93F757FF3FFADA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei234 – 2341Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB274410 mRNA. Translation: BAF48997.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB274410 mRNA. Translation: BAF48997.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QAD X-ray 3.30 D/H 33-228 [» ]
    ProteinModelPortali A4F255.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Proteomic databases

    PaxDbi A4F255.
    PRIDEi A4F255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG313034.
    HOVERGENi HBG005814.

    Miscellaneous databases

    NextBioi 35461721.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4."
      Huang C.C., Lam S.N., Acharya P., Tang M., Xiang S.H., Hussan S.S., Stanfield R.L., Robinson J., Sodroski J., Wilson I.A., Wyatt R., Bewley C.A., Kwong P.D.
      Science 317:1930-1934(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 33-228.
    2. "Identification of a human monoclonal Fab with neutralizing activity against H3N2 influenza A strain from a newly constructed human Fab library."
      Shibuya T., Yamashiro T., Masaike Y., Ohuchi M., Uechi G., Nishizono A.
      Microbiol. Immunol. 52:162-170(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA4F255_HUMAN
    AccessioniPrimary (citable) accession number: A4F255
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3