Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4D7S0

- WNT2_BOVIN

UniProt

A4D7S0 - WNT2_BOVIN

Protein

Protein Wnt-2

Gene

WNT2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    2. canonical Wnt signaling pathway Source: Ensembl
    3. cardiac epithelial to mesenchymal transition Source: Ensembl
    4. cell fate commitment Source: RefGenome
    5. cellular response to transforming growth factor beta stimulus Source: Ensembl
    6. labyrinthine layer blood vessel development Source: Ensembl
    7. lung induction Source: Ensembl
    8. mammary gland epithelium development Source: Ensembl
    9. neuron differentiation Source: RefGenome
    10. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    11. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    12. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    13. positive regulation of fibroblast proliferation Source: Ensembl
    14. positive regulation of mesenchymal cell proliferation Source: Ensembl
    15. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_204109. Class B/2 (Secretin family receptors).
    REACT_209527. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2
    Gene namesi
    Name:WNT2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: RefGenome
    3. plasma membrane Source: Ensembl
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 360335Protein Wnt-2PRO_0000284947Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 87By similarity
    Disulfide bondi127 ↔ 135By similarity
    Disulfide bondi137 ↔ 157By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiA4D7S0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000010650.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115400.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiA4D7S0.
    KOiK00182.
    OMAiWKKYNGA.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4D7S0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNACLVGIWL WLPLLFTWLS PEVSSSWWYM RATSGSSRVM CDNVPGLVSH    50
    QRQLCHRHPD VMRAIGLGVT EWTMECQHQF RQHRWNCNTL DRDHSLFGRV 100
    LLRSSRESAF VYAISSAGVV FAITRACSQG ELKSCSCDPK KKGTAKDNKG 150
    TFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR 200
    FLKQECKCHG VSGSCTLRTC WLAMADFRKT GNYLWRKYNG AIQVVMNQDG 250
    TGFTVANKRF KKPTKNDLVY FENSPDYCIR DRDAGSLGTA GRVCNLTSRG 300
    MDSCEVMCCG RGYDTSHITR KTKCECKFHW CCAVRCQDCV EALDVHTCKA 350
    PKSPDWAAPT 360
    Length:360
    Mass (Da):40,643
    Last modified:April 3, 2007 - v1
    Checksum:i1E4ACAC9E18D8A80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000008 Genomic DNA. Translation: AAR16261.1.
    RefSeqiNP_001013019.1. NM_001013001.1.
    UniGeneiBt.37360.

    Genome annotation databases

    EnsembliENSBTAT00000010650; ENSBTAP00000010650; ENSBTAG00000008097.
    GeneIDi493729.
    KEGGibta:493729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000008 Genomic DNA. Translation: AAR16261.1 .
    RefSeqi NP_001013019.1. NM_001013001.1.
    UniGenei Bt.37360.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000010650.

    Proteomic databases

    PRIDEi A4D7S0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010650 ; ENSBTAP00000010650 ; ENSBTAG00000008097 .
    GeneIDi 493729.
    KEGGi bta:493729.

    Organism-specific databases

    CTDi 7472.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115400.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi A4D7S0.
    KOi K00182.
    OMAi WKKYNGA.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_204109. Class B/2 (Secretin family receptors).
    REACT_209527. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 20865472.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of multi-species sequences from targeted genomic regions."
      Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
      , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
      Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiWNT2_BOVIN
    AccessioniPrimary (citable) accession number: A4D7S0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3