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Protein

Delphilin

Gene

GRID2IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Delphilin
Alternative name(s):
Glutamate receptor, ionotropic, delta 2-interacting protein 1
Gene namesi
Name:GRID2IP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18464. GRID2IP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951825.

Polymorphism and mutation databases

BioMutaiGRID2IP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12111211DelphilinPRO_0000331624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei580 – 5801PhosphoserineBy similarity
Modified residuei621 – 6211PhosphoserineBy similarity
Modified residuei652 – 6521PhosphoserineBy similarity
Modified residuei655 – 6551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA4D2P6.
PRIDEiA4D2P6.

PTM databases

PhosphoSiteiA4D2P6.

Expressioni

Gene expression databases

BgeeiA4D2P6.
CleanExiHS_GRID2IP.
ExpressionAtlasiA4D2P6. baseline and differential.

Organism-specific databases

HPAiHPA045381.

Interactioni

Subunit structurei

Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain.By similarity

Protein-protein interaction databases

BioGridi134314. 1 interaction.
DIPiDIP-59489N.
STRINGi9606.ENSP00000397351.

Structurei

3D structure databases

ProteinModelPortaliA4D2P6.
SMRiA4D2P6. Positions 15-83, 275-352, 829-1190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8482PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 35678PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini820 – 1211392FH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi581 – 66282Pro-richAdd
BLAST
Compositional biasi750 – 81263Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 FH2 (formin homology 2) domain.PROSITE-ProRule annotation
Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
KOG3528. Eukaryota.
ENOG410XSM6. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000112812.
HOVERGENiHBG107964.
InParanoidiA4D2P6.
OMAiCQSMSPS.
PhylomeDBiA4D2P6.
TreeFamiTF329416.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015425. FH2_Formin.
IPR001478. PDZ.
[Graphical view]
PfamiPF02181. FH2. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
SM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS51444. FH2. 1 hit.
PS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D2P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTATPATN QGWPEDFGFR LGGSGPCFVL EVAKGSSAHA GGLRPGDQIL
60 70 80 90 100
EVEGLAVGGL SRERLVRLAR RCPRVPPSLG VLPAPDGGPG PGSGPAAPTT
110 120 130 140 150
VLRAPRCGRG LALGRELLRL AGRKRPDAVH RERRRKAQEF SRKVDEILGD
160 170 180 190 200
QPTAKEQVFA ALKQFAAEQR VDDLVWTLTL ALPREACGPL LDNLRIFIPK
210 220 230 240 250
KHRARFDEVV SQGLLGKLCR ARRAQGAQRL RRSRSEERPE RLLVSTRASA
260 270 280 290 300
PPRRPDEPPP RRASLLVGGL AGPGGARRTV RVYKGNKSFG FTLRGHGPVW
310 320 330 340 350
IESVLPGSPA DNAALKSGDR ILFLNGLDMR NCSHDKVVSM LQGSGAMPTL
360 370 380 390 400
VVEEGLVPFA SDSDSLDSPN PSSALTSLQW VAEILPSSIR VQGRTFSQQL
410 420 430 440 450
EHLLTPPERY GVCRALESFF QHRNIDTLIV DVYPVLDTPA KQVLWQFIYQ
460 470 480 490 500
LLTYEEQELC QEKIACFLGY TAMTAEPEPE LDLESEPTPE PQPRSSLRAS
510 520 530 540 550
SMCRRSLRSQ GLEAGLSCGP SECPEMPLPL IPGERQAGDG TSLPETPNPK
560 570 580 590 600
MMSAVYAELE SRLNSSFKGK MGTVSKSRAS PPGPSPAVTT GPRTLSGVSW
610 620 630 640 650
PSERLLPSPC YHPLCSGGLA SPSSSESHPY ASLDSSRAPS PQPGPGPICP
660 670 680 690 700
DSPPSPDPTR PPSRRKLFTF SHPVRSRDTD RFLDVLSEQL GPRVTIVDDF
710 720 730 740 750
LTPENDYEEM SFHDDQGSFV TNERSSASDC ISSSEEGSSL TYSSISDHIP
760 770 780 790 800
PPPLSPPPPP PLPFHDAKPS SRSSDGSRGP AQALAKPLTQ LSHPVPPPPP
810 820 830 840 850
PPLPPPVPCA PPMLSRGLGH RRSETSHMSV KRLRWEQVEN SEGTIWGQLG
860 870 880 890 900
EDSDYDKLSD MVKYLDLELH FGTQKPAKPV PGPEPFRKKE VVEILSHKKA
910 920 930 940 950
YNTSILLAHL KLSPAELRQV LMSMEPRRLE PAHLAQLLLF APDADEEQRY
960 970 980 990 1000
QAFREAPGRL SEPDQFVLQM LSVPEYKTRL RSLHFQATLQ EKTEEIRGSL
1010 1020 1030 1040 1050
ECLRQASLEL KNSRKLAKIL EFVLAMGNYL NDGQPKTNKT TGFKINFLTE
1060 1070 1080 1090 1100
LNSTKTVDGK STFLHILAKS LSQHFPELLG FAQDLPTVPL AAKVNQRALT
1110 1120 1130 1140 1150
SDLADLHGTI SEIQDACQSI SPSSEDKFAM VMSSFLETAQ PALRALDGLQ
1160 1170 1180 1190 1200
REAMEELGKA LAFFGEDSKA TTSEAFFGIF AEFMSKFERA LSDLQAGEGL
1210
RSSGMVSPLA W
Length:1,211
Mass (Da):132,276
Last modified:April 29, 2008 - v2
Checksum:i44D7B5C97461E2E0
GO

Sequence cautioni

The sequence EAL23724.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201R → Q.
Corresponds to variant rs11761490 [ dbSNP | Ensembl ].
VAR_042909

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC072052 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23724.1. Sequence problems.
CCDSiCCDS47537.1.
RefSeqiNP_001138590.1. NM_001145118.1.
UniGeneiHs.512174.

Genome annotation databases

EnsembliENST00000457091; ENSP00000397351; ENSG00000215045.
GeneIDi392862.
KEGGihsa:392862.
UCSCiuc011jwx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC072052 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23724.1. Sequence problems.
CCDSiCCDS47537.1.
RefSeqiNP_001138590.1. NM_001145118.1.
UniGeneiHs.512174.

3D structure databases

ProteinModelPortaliA4D2P6.
SMRiA4D2P6. Positions 15-83, 275-352, 829-1190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134314. 1 interaction.
DIPiDIP-59489N.
STRINGi9606.ENSP00000397351.

PTM databases

PhosphoSiteiA4D2P6.

Polymorphism and mutation databases

BioMutaiGRID2IP.

Proteomic databases

PaxDbiA4D2P6.
PRIDEiA4D2P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457091; ENSP00000397351; ENSG00000215045.
GeneIDi392862.
KEGGihsa:392862.
UCSCiuc011jwx.3. human.

Organism-specific databases

CTDi392862.
GeneCardsiGRID2IP.
HGNCiHGNC:18464. GRID2IP.
HPAiHPA045381.
MIMi610639. gene.
neXtProtiNX_A4D2P6.
PharmGKBiPA134951825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
KOG3528. Eukaryota.
ENOG410XSM6. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000112812.
HOVERGENiHBG107964.
InParanoidiA4D2P6.
OMAiCQSMSPS.
PhylomeDBiA4D2P6.
TreeFamiTF329416.

Miscellaneous databases

GenomeRNAii392862.
NextBioi105345.
PROiA4D2P6.
SOURCEiSearch...

Gene expression databases

BgeeiA4D2P6.
CleanExiHS_GRID2IP.
ExpressionAtlasiA4D2P6. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015425. FH2_Formin.
IPR001478. PDZ.
[Graphical view]
PfamiPF02181. FH2. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
SM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS51444. FH2. 1 hit.
PS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 12:1015-1019(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
  4. "Characterization of the delta2 glutamate receptor-binding protein delphilin: splicing variants with differential palmitoylation and an additional PDZ domain."
    Matsuda K., Matsuda S., Gladding C.M., Yuzaki M.
    J. Biol. Chem. 281:25577-25587(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
    Tissue: Cerebellum.

Entry informationi

Entry nameiGRD2I_HUMAN
AccessioniPrimary (citable) accession number: A4D2P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 16, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.