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Unreviewed, UniProtKB/TrEMBL A4D2P0 (A4D2P0_HUMAN)

Last modified February 9, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA EMBL BAF84504.1
Submitted name:
    Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1) EMBL EAL23718.1
    Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e EMBL EAW55044.1
Gene names
Name: RAC1 EMBL EAL23718.1
ORF Names: hCG_14926 EMBL EAW55044.1, tcag7.839 EMBL EAL23718.1
OrganismHomo sapiens (Human) EMBL EAL23718.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

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Ontologies

Keywords
   Cellular componentMembrane Spearmint SPM003578
   LigandGTP-binding RuleBase RU003312V0 Spearmint SPM003578
Nucleotide-binding
Gene Ontology (GO)
   Biological processaxon guidance

Inferred from electronic annotation. Source: Compara

cell adhesion

Inferred from electronic annotation. Source: Compara

cerebral cortex radially oriented cell migration

Inferred from electronic annotation. Source: Compara

cytoskeleton organization

Inferred from electronic annotation. Source: Compara

dendrite development

Inferred from electronic annotation. Source: Compara

embryonic olfactory bulb interneuron precursor migration

Inferred from electronic annotation. Source: Compara

endocytosis

Inferred from electronic annotation. Source: Compara

hyperosmotic response

Inferred from electronic annotation. Source: Compara

positive regulation of actin filament polymerization

Inferred from electronic annotation. Source: Compara

positive regulation of phosphoinositide 3-kinase activity

Inferred from electronic annotation. Source: Compara

regulation of cell migration

Inferred from electronic annotation. Source: Compara

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: Compara

   Cellular componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: Compara

extrinsic to plasma membrane

Inferred from electronic annotation. Source: Compara

lamellipodium

Inferred from electronic annotation. Source: Compara

membrane fraction

Inferred from electronic annotation. Source: Compara

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
A4D2P0-1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 93745E0CFBA5281F

FASTA21123,467
        10         20         30         40         50         60 
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 

        70         80         90        100        110        120 
QEDYDRLRPL SYPQTVGETY GKDITSRGKD KPIADVFLIC FSLVSPASFE NVRAKWYPEV 

       130        140        150        160        170        180 
RHHCPNTPII LVGTKLDLRD DKDTIEKLKE KKLTPITYPQ GLAMAKEIGA VKYLECSALT 

       190        200        210 
QRGLKTVFDE AIRAVLCPPP VKKRKRKCLL L

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References

« Hide 'large scale' references
[1]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed: 12690205] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Nusskern D., Zhang Q., Gu Z., Lu F., Zeesman S., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P., Lococo F., Belloni E., Shaffer L.G., Morton C.C., Pober B., Gusella J., Bruns G., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.Angel., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[5]"NEDO human cDNA sequencing project."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Prostate EMBL BAF84504.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK291815 mRNA. Translation: BAF84504.1.
CH236963 Genomic DNA. Translation: EAL23718.1.
CH878731 Genomic DNA. Translation: EAW55044.1.
IPIIPI00219675.
RefSeqNP_061485.1.
UniGeneHs.413812

3D structure databases

SMRA4D2P0. Positions 1-211.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4D2P0.

Proteomic databases

PRIDEA4D2P0.

Genome annotation databases

EnsemblENST00000356142; ENSP00000348461; ENSG00000136238; Homo sapiens. [Genome view]
GeneID5879.

Organism-specific databases

CTD5879.
HGNCHGNC:9801. RAC1.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12205.
HOGENOMHBG745225.
OMADTYGKDI.
OrthoDBEOG9X0QC9.
PhylomeDBA4D2P0.

Gene expression databases

BgeeA4D2P0.

Family and domain databases

InterProIPR003578. GTPase_Rho.
IPR013753. Ras.
IPR001806. Ras_GTPase.
IPR005225. Small_GTP_bd.
[Graphical view]
PfamPF00071. Ras. 2 hits.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio22846.
PMAP-CutDBA4D2P0.

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Entry information

Entry nameA4D2P0_HUMAN
AccessionPrimary (citable) accession number: A4D2P0
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information