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A4D2P0

- A4D2P0_HUMAN

UniProt

A4D2P0 - A4D2P0_HUMAN

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Protein
Submitted name: Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)
Gene
RAC1, hCG_14926, tcag7.839
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: Ensembl

GO - Biological processi

  1. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
  2. actin filament organization Source: Ensembl
  3. anatomical structure arrangement Source: Ensembl
  4. auditory receptor cell morphogenesis Source: Ensembl
  5. axon guidance Source: Ensembl
  6. bone resorption Source: Ensembl
  7. cell proliferation Source: Ensembl
  8. cell-cell junction organization Source: Ensembl
  9. cerebral cortex radially oriented cell migration Source: Ensembl
  10. cochlea morphogenesis Source: Ensembl
  11. dendrite morphogenesis Source: Ensembl
  12. dopaminergic neuron differentiation Source: Ensembl
  13. embryonic olfactory bulb interneuron precursor migration Source: Ensembl
  14. engulfment of apoptotic cell Source: Ensembl
  15. epithelial cell morphogenesis Source: Ensembl
  16. hyperosmotic response Source: Ensembl
  17. mast cell chemotaxis Source: Ensembl
  18. positive regulation of DNA replication Source: Ensembl
  19. positive regulation of actin filament polymerization Source: Ensembl
  20. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  21. regulation of cell migration Source: Ensembl
  22. ruffle assembly Source: Ensembl
  23. small GTPase mediated signal transduction Source: Ensembl
  24. substrate adhesion-dependent cell spreading Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)Imported
Submitted name:
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_eImported
Submitted name:
cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNAImported
Gene namesi
Name:RAC1Imported
ORF Names:hCG_14926Imported, tcag7.839Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: Ensembl
  2. cytoplasmic membrane-bounded vesicle Source: Ensembl
  3. extrinsic component of plasma membrane Source: Ensembl
  4. lamellipodium Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotations

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34162.

PTM / Processingi

Miscellaneous databases

PMAP-CutDBA4D2P0.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000233974.
HOVERGENiHBG009351.
KOiK04392.
OMAiYPQTVAE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 2 hits.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D2P0-1 [UniParc]FASTAAdd to Basket

« Hide

MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP    50
VNLGLWDTAG QEDYDRLRPL SYPQTVGETY GKDITSRGKD KPIADVFLIC 100
FSLVSPASFE NVRAKWYPEV RHHCPNTPII LVGTKLDLRD DKDTIEKLKE 150
KKLTPITYPQ GLAMAKEIGA VKYLECSALT QRGLKTVFDE AIRAVLCPPP 200
VKKRKRKCLL L 211
Length:211
Mass (Da):23,467
Last modified:April 3, 2007 - v1
Checksum:i93745E0CFBA5281F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291815 mRNA. Translation: BAF84504.1.
CH236963 Genomic DNA. Translation: EAL23718.1.
CH878731 Genomic DNA. Translation: EAW55044.1.
RefSeqiNP_061485.1. NM_018890.3.
UniGeneiHs.413812.

Genome annotation databases

GeneIDi5879.
KEGGihsa:5879.
UCSCiuc003spw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291815 mRNA. Translation: BAF84504.1 .
CH236963 Genomic DNA. Translation: EAL23718.1 .
CH878731 Genomic DNA. Translation: EAW55044.1 .
RefSeqi NP_061485.1. NM_018890.3.
UniGenei Hs.413812.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5879.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5879.
KEGGi hsa:5879.
UCSCi uc003spw.3. human.

Organism-specific databases

CTDi 5879.
PharmGKBi PA34162.

Phylogenomic databases

HOGENOMi HOG000233974.
HOVERGENi HBG009351.
KOi K04392.
OMAi YPQTVAE.

Miscellaneous databases

ChiTaRSi RAC1. human.
GenomeRNAii 5879.
NextBioi 22846.
PMAP-CutDB A4D2P0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 2 hits.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J., Grzeschik K.H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Dohner H., Dohner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Nusskern D., Zhang Q., Gu Z., Lu F., Zeesman S., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P., Lococo F., Belloni E., Shaffer L.G., Morton C.C., Pober B., Gusella J., Bruns G., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.Angel., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ProstateImported.

Entry informationi

Entry nameiA4D2P0_HUMAN
AccessioniPrimary (citable) accession number: A4D2P0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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