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Protein

Insulin-induced gene protein

Gene

INSIG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates feedback control of cholesterol synthesis.UniRule annotation

GO - Biological processi

Keywordsi

Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-induced gene proteinUniRule annotation
Gene namesi
Name:INSIG1Imported
ORF Names:hCG_1641980Imported, tcag7.832Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 107HelicalUniRule annotationAdd BLAST19
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 204HelicalUniRule annotationAdd BLAST22
Transmembranei211 – 230HelicalUniRule annotationAdd BLAST20
Transmembranei242 – 262HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiA4D2M9
PRIDEiA4D2M9

Family & Domainsi

Sequence similaritiesi

Belongs to the INSIG family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG4363 Eukaryota
ENOG410XQ2M LUCA
HOGENOMiHOG000253021
HOVERGENiHBG058958

Family and domain databases

InterProiView protein in InterPro
IPR009904 INSIG-1
IPR025929 INSIG_fam
PANTHERiPTHR15301 PTHR15301, 1 hit
PTHR15301:SF11 PTHR15301:SF11, 1 hit
PfamiView protein in Pfam
PF07281 INSIG, 1 hit

Sequencei

Sequence statusi: Complete.

A4D2M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA
60 70 80 90 100
HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL
110 120 130 140 150
VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH
160 170 180 190 200
LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL
210 220 230 240 250
WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC
260 270 280 290 300
IFFSGGVTVG NIGRQLAMLI PFCEELNLKT TWLFHKTRSN YRVFLKSPIV
310 320 330
IESSKPPILR ARKILEENLT VDYDKDYLFS
Length:330
Mass (Da):36,452
Last modified:April 3, 2007 - v1
Checksum:i26F51232C0875C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236962 Genomic DNA Translation: EAL23728.1
CH471149 Genomic DNA Translation: EAX04531.1
RefSeqiNP_001333519.1, NM_001346590.1
NP_001333520.1, NM_001346591.1
XP_005249599.1, XM_005249542.1
XP_005249600.1, XM_005249543.1
UniGeneiHs.520819

Genome annotation databases

GeneIDi3638

Similar proteinsi

Entry informationi

Entry nameiA4D2M9_HUMAN
AccessioniPrimary (citable) accession number: A4D2M9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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