ID   O2A25_HUMAN             Reviewed;         310 AA.
AC   A4D2G3; B2RNC9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=Olfactory receptor 2A25;
DE   AltName: Full=Olfactory receptor 2A27;
GN   Name=OR2A25; Synonyms=OR2A25P, OR2A27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ASN-75 AND
RP   PRO-209.
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A25";
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DR   EMBL; AC091768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236959; EAL23797.1; -; Genomic_DNA.
DR   EMBL; BC136814; AAI36815.1; -; mRNA.
DR   EMBL; BC136829; AAI36830.1; -; mRNA.
DR   CCDS; CCDS43669.1; -.
DR   RefSeq; NP_001004488.1; NM_001004488.1.
DR   AlphaFoldDB; A4D2G3; -.
DR   SMR; A4D2G3; -.
DR   BioGRID; 134111; 1.
DR   STRING; 9606.ENSP00000493343; -.
DR   GlyCosmos; A4D2G3; 1 site, No reported glycans.
DR   GlyGen; A4D2G3; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; A4D2G3; -.
DR   PhosphoSitePlus; A4D2G3; -.
DR   BioMuta; OR2A25; -.
DR   MassIVE; A4D2G3; -.
DR   PaxDb; 9606-ENSP00000386167; -.
DR   PeptideAtlas; A4D2G3; -.
DR   Antibodypedia; 64076; 64 antibodies from 17 providers.
DR   DNASU; 392138; -.
DR   Ensembl; ENST00000408898.2; ENSP00000386167.2; ENSG00000221933.3.
DR   Ensembl; ENST00000641441.1; ENSP00000493159.1; ENSG00000221933.3.
DR   Ensembl; ENST00000641663.1; ENSP00000493343.1; ENSG00000221933.3.
DR   GeneID; 392138; -.
DR   KEGG; hsa:392138; -.
DR   MANE-Select; ENST00000641663.1; ENSP00000493343.1; NM_001386096.1; NP_001373025.1.
DR   UCSC; uc011ktx.3; human.
DR   AGR; HGNC:19562; -.
DR   CTD; 392138; -.
DR   GeneCards; OR2A25; -.
DR   HGNC; HGNC:19562; OR2A25.
DR   HPA; ENSG00000221933; Not detected.
DR   neXtProt; NX_A4D2G3; -.
DR   PharmGKB; PA134892120; -.
DR   VEuPathDB; HostDB:ENSG00000221933; -.
DR   eggNOG; ENOG502SM15; Eukaryota.
DR   GeneTree; ENSGT00940000161677; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; A4D2G3; -.
DR   OMA; HINETMV; -.
DR   OrthoDB; 5259681at2759; -.
DR   PhylomeDB; A4D2G3; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; A4D2G3; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 392138; 15 hits in 735 CRISPR screens.
DR   GenomeRNAi; 392138; -.
DR   Pharos; A4D2G3; Tdark.
DR   PRO; PR:A4D2G3; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A4D2G3; Protein.
DR   Bgee; ENSG00000221933; Expressed in apex of heart and 2 other cell types or tissues.
DR   ExpressionAtlas; A4D2G3; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15420; 7tmA_OR2A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF257; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Olfactory receptor 2A25"
FT                   /id="PRO_0000293718"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         75
FT                   /note="S -> N (in dbSNP:rs6951485)"
FT                   /evidence="ECO:0000269|PubMed:12690205"
FT                   /id="VAR_054664"
FT   VARIANT         209
FT                   /note="A -> P (in dbSNP:rs2961135)"
FT                   /evidence="ECO:0000269|PubMed:12690205"
FT                   /id="VAR_054665"
SQ   SEQUENCE   310 AA;  34606 MW;  57E11DC1FFF050B3 CRC64;
     MGGNQTSITE FLLLGFPIGP RIQMLLFGLF SLFYIFILLG NGTILGLISL DSRLHTPMYF
     FLSHLAVVDI ACACSTVPQM LVNLLHPAKP ISFAGCMTQM FLFLSFAHTE CLLLVVMSYD
     RYVAICHPLR YSTIMTWKVC ITLALTSWIL GVLLALVHLV LLLPLSFCGP QKLNHFFCEI
     MAVLKLACAD THINEVMVLA GAVSVLVGAF FSTVISYVHI LCAILKIQSG EGCQKAFSIC
     SSHLCVVGLF YGTAIIMYVE PQYESPKEQK KYLLLFHSLF NPMLNPLIYS LRNKEVQGTL
     KRMLEKKRTS
//