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A4D2G3

- O2A25_HUMAN

UniProt

A4D2G3 - O2A25_HUMAN

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Protein

Olfactory receptor 2A25

Gene
OR2A25, OR2A25P, OR2A27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A25
Alternative name(s):
Olfactory receptor 2A27
Gene namesi
Name:OR2A25
Synonyms:OR2A25P, OR2A27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19562. OR2A25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed predictionAdd
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7822Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9921Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 11920Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15719Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini158 – 19538Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21823Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 23517Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 31019Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A25PRO_0000293718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA4D2G3.

PTM databases

PhosphoSiteiA4D2G3.

Expressioni

Gene expression databases

CleanExiHS_OR2A25.
GenevestigatoriA4D2G3.

Organism-specific databases

HPAiHPA058272.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386167.

Structurei

3D structure databases

ProteinModelPortaliA4D2G3.
SMRiA4D2G3. Positions 26-156.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266913.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA4D2G3.
KOiK04257.
OMAiHINEVMV.
OrthoDBiEOG793B85.
PhylomeDBiA4D2G3.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D2G3-1 [UniParc]FASTAAdd to Basket

« Hide

MGGNQTSITE FLLLGFPIGP RIQMLLFGLF SLFYIFILLG NGTILGLISL    50
DSRLHTPMYF FLSHLAVVDI ACACSTVPQM LVNLLHPAKP ISFAGCMTQM 100
FLFLSFAHTE CLLLVVMSYD RYVAICHPLR YSTIMTWKVC ITLALTSWIL 150
GVLLALVHLV LLLPLSFCGP QKLNHFFCEI MAVLKLACAD THINEVMVLA 200
GAVSVLVGAF FSTVISYVHI LCAILKIQSG EGCQKAFSIC SSHLCVVGLF 250
YGTAIIMYVE PQYESPKEQK KYLLLFHSLF NPMLNPLIYS LRNKEVQGTL 300
KRMLEKKRTS 310
Length:310
Mass (Da):34,606
Last modified:March 24, 2009 - v2
Checksum:i57E11DC1FFF050B3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751S → N.1 Publication
Corresponds to variant rs6951485 [ dbSNP | Ensembl ].
VAR_054664
Natural varianti209 – 2091A → P.1 Publication
Corresponds to variant rs2961135 [ dbSNP | Ensembl ].
VAR_054665

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091768 Genomic DNA. No translation available.
CH236959 Genomic DNA. Translation: EAL23797.1.
BC136814 mRNA. Translation: AAI36815.1.
BC136829 mRNA. Translation: AAI36830.1.
CCDSiCCDS43669.1.
RefSeqiNP_001004488.1. NM_001004488.1.
UniGeneiHs.553787.

Genome annotation databases

EnsembliENST00000408898; ENSP00000386167; ENSG00000221933.
GeneIDi392138.
KEGGihsa:392138.
UCSCiuc011ktx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091768 Genomic DNA. No translation available.
CH236959 Genomic DNA. Translation: EAL23797.1 .
BC136814 mRNA. Translation: AAI36815.1 .
BC136829 mRNA. Translation: AAI36830.1 .
CCDSi CCDS43669.1.
RefSeqi NP_001004488.1. NM_001004488.1.
UniGenei Hs.553787.

3D structure databases

ProteinModelPortali A4D2G3.
SMRi A4D2G3. Positions 26-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386167.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei A4D2G3.

Proteomic databases

PRIDEi A4D2G3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408898 ; ENSP00000386167 ; ENSG00000221933 .
GeneIDi 392138.
KEGGi hsa:392138.
UCSCi uc011ktx.2. human.

Organism-specific databases

CTDi 392138.
GeneCardsi GC07P143771.
HGNCi HGNC:19562. OR2A25.
HPAi HPA058272.
neXtProti NX_A4D2G3.
PharmGKBi PA134892120.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266913.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi A4D2G3.
KOi K04257.
OMAi HINEVMV.
OrthoDBi EOG793B85.
PhylomeDBi A4D2G3.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

NextBioi 104963.
PROi A4D2G3.

Gene expression databases

CleanExi HS_OR2A25.
Genevestigatori A4D2G3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ASN-75 AND PRO-209.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO2A25_HUMAN
AccessioniPrimary (citable) accession number: A4D2G3
Secondary accession number(s): B2RNC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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