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Protein

Actin-related protein 2/3 complex subunit

Gene

ARPC1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunitUniRule annotation
Gene namesi
Name:ARPC1BImported
ORF Names:hCG_19475Imported, tcag7.662Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000130429.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24998

Expressioni

Gene expression databases

BgeeiENSG00000130429

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 89WD_REPEATS_REGIONInterPro annotationAdd BLAST42
Repeati48 – 82WDPROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.UniRule annotation

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
HOGENOMiHOG000181752
HOVERGENiHBG050560
KOiK05757
OMAiVLFTYDS
OrthoDBiEOG091G096H

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

A4D275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAL
260 270 280 290 300
TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):40,950
Last modified:April 3, 2007 - v1
Checksum:i1939F5B63D40BD27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314818 mRNA Translation: BAG37341.1
CH236956 Genomic DNA Translation: EAL23882.1
CH471091 Genomic DNA Translation: EAW76677.1
CH471091 Genomic DNA Translation: EAW76678.1
CH471091 Genomic DNA Translation: EAW76679.1
CH471091 Genomic DNA Translation: EAW76680.1
RefSeqiNP_005711.1, NM_005720.3
XP_006715888.1, XM_006715825.1
XP_006715889.1, XM_006715826.1
UniGeneiHs.489284

Genome annotation databases

GeneIDi10095
KEGGihsa:10095

Similar proteinsi

Entry informationi

Entry nameiA4D275_HUMAN
AccessioniPrimary (citable) accession number: A4D275
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health