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A4D256

- CC14C_HUMAN

UniProt

A4D256 - CC14C_HUMAN

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Protein

Dual specificity protein phosphatase CDC14C

Gene

CDC14C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14C (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14C
Synonyms:CDC14B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:22427. CDC14C.

Subcellular locationi

Membrane Curated; Single-pass membrane protein Curated. Nucleusnucleolus
Note: Nucleolar during interphase.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Dual specificity protein phosphatase CDC14CPRO_0000315822Add
BLAST

Proteomic databases

PaxDbiA4D256.
PRIDEiA4D256.

PTM databases

PhosphoSiteiA4D256.

Expressioni

Gene expression databases

CleanExiHS_CDC14C.
GenevestigatoriA4D256.

Organism-specific databases

HPAiHPA013312.

Structurei

3D structure databases

ProteinModelPortaliA4D256.
SMRiA4D256. Positions 119-456.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei522 – 54423HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 275155ABy similarityAdd
BLAST
Regioni276 – 28914LinkerBy similarityAdd
BLAST
Regioni290 – 456167BBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi78 – 13154Nucleolar localization signalBy similarityAdd
BLAST

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2453.
HOVERGENiHBG050818.
InParanoidiA4D256.
PhylomeDBiA4D256.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D256-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEVSSECGK KCEPLGCSST NGDLQGEAGA VVSIFLRMVP RIKSNEGYGY
60 70 80 90 100
SNRNWRKENT MHSLDRNIVD GGQALGQWKR KSKGRSSWAA APHCSPRCSL
110 120 130 140 150
TSQGVKKMRS STLQDPRRRD PQDDVYVDIT DRLRFAILYS RPKSASNVHY
160 170 180 190 200
FSIDNELEYE NFSEDFGPLN LAMVYRYCCK INKKLKSITM LRKKIVHFTG
210 220 230 240 250
SDQRKQANAA FLVGCYMVIY LGRTPEAAYR ILIFGDTPYI PFRDAAYGSC
260 270 280 290 300
NFYITLLDCF HAVKKAMQYG FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR
310 320 330 340 350
FIAFCGPHSR ARLESGYHQH SPETYIQYFK NHNVTTIIRL NKRMYDAKRF
360 370 380 390 400
TDAGFDHHDL FFADGSTPTD AIVKRFLDIC ENAEGAIAVH CKAGLGRTGT
410 420 430 440 450
LIACYIMKHY RMTAAETIAW VRICRPGLVI GPQQQFLVMK QTSLWLEGDY
460 470 480 490 500
FRQRLKGQEN GQHRAAFSKL LSGVDDISIN GVENQDQQEP KPYSDDDEIN
510 520 530 540 550
GVTQGDRSRA LKRRRQSKTN DILLPSPLAV LTFTLCSVVI WWIVCDYILP

ILLF
Length:554
Mass (Da):63,299
Last modified:November 24, 2009 - v2
Checksum:i22B7014D4C2A60A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 8818GGQAL…GRSSW → LIGRGRLQEAEKQGAVEL in BC068452. (PubMed:15489334)CuratedAdd
BLAST
Sequence conflicti75 – 784LGQW → AASR in BC028690. (PubMed:15489334)Curated
Sequence conflicti78 – 781W → R in ABB92421. (PubMed:16201836)Curated
Sequence conflicti93 – 931H → L in EAL23906. (PubMed:12690205)Curated
Sequence conflicti96 – 961P → Q in EAL23906. (PubMed:12690205)Curated
Sequence conflicti102 – 1021S → L in EAL23906. (PubMed:12690205)Curated
Sequence conflicti103 – 1031Q → P in BC068452. (PubMed:15489334)Curated
Sequence conflicti103 – 1031Q → P in ABB92421. (PubMed:16201836)Curated
Sequence conflicti119 – 1191R → W in EAL23906. (PubMed:12690205)Curated
Sequence conflicti127 – 1271V → L in EAL23906. (PubMed:12690205)Curated
Sequence conflicti127 – 1271V → L in BC028690. (PubMed:15489334)Curated
Sequence conflicti454 – 4541R → K in EAL23906. (PubMed:12690205)Curated
Sequence conflicti494 – 4941S → G in EAL23906. (PubMed:12690205)Curated
Sequence conflicti494 – 4941S → G in BC068452. (PubMed:15489334)Curated
Sequence conflicti494 – 4941S → G in ABB92421. (PubMed:16201836)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381P → S.
Corresponds to variant rs1615556 [ dbSNP | Ensembl ].
VAR_038327
Natural varianti296 – 2961I → L.
Corresponds to variant rs421206 [ dbSNP | Ensembl ].
VAR_038328

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1.
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1.
UniGeneiHs.567757.

Genome annotation databases

UCSCiuc010kyv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1 .
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1 .
UniGenei Hs.567757.

3D structure databases

ProteinModelPortali A4D256.
SMRi A4D256. Positions 119-456.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A4D256.

Proteomic databases

PaxDbi A4D256.
PRIDEi A4D256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010kyv.1. human.

Organism-specific databases

GeneCardsi GC07P048960.
H-InvDB HIX0033628.
HGNCi HGNC:22427. CDC14C.
HPAi HPA013312.
neXtProti NX_A4D256.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
HOVERGENi HBG050818.
InParanoidi A4D256.
PhylomeDBi A4D256.

Miscellaneous databases

PROi A4D256.

Gene expression databases

CleanExi HS_CDC14C.
Genevestigatori A4D256.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-554.
    Tissue: Testis.
  4. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-536.

Entry informationi

Entry nameiCC14C_HUMAN
AccessioniPrimary (citable) accession number: A4D256
Secondary accession number(s): Q2VIP7, Q6NUS3, Q8NCT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May act as an autosomal functional substitute.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3