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Protein

Dual specificity protein phosphatase CDC14C

Gene

CDC14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS11321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14C (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14C
Synonyms:CDC14B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:22427. CDC14C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei522 – 544HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi168448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158221 – 554Dual specificity protein phosphatase CDC14CAdd BLAST554

Proteomic databases

PRIDEiA4D256.

PTM databases

DEPODiA4D256.
iPTMnetiA4D256.
PhosphoSitePlusiA4D256.

Expressioni

Gene expression databases

CleanExiHS_CDC14C.

Organism-specific databases

HPAiHPA013312.

Structurei

3D structure databases

ProteinModelPortaliA4D256.
SMRiA4D256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 275ABy similarityAdd BLAST155
Regioni276 – 289LinkerBy similarityAdd BLAST14
Regioni290 – 456BBy similarityAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 131Nucleolar localization signalBy similarityAdd BLAST54

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG050818.
InParanoidiA4D256.
PhylomeDBiA4D256.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEVSSECGK KCEPLGCSST NGDLQGEAGA VVSIFLRMVP RIKSNEGYGY
60 70 80 90 100
SNRNWRKENT MHSLDRNIVD GGQALGQWKR KSKGRSSWAA APHCSPRCSL
110 120 130 140 150
TSQGVKKMRS STLQDPRRRD PQDDVYVDIT DRLRFAILYS RPKSASNVHY
160 170 180 190 200
FSIDNELEYE NFSEDFGPLN LAMVYRYCCK INKKLKSITM LRKKIVHFTG
210 220 230 240 250
SDQRKQANAA FLVGCYMVIY LGRTPEAAYR ILIFGDTPYI PFRDAAYGSC
260 270 280 290 300
NFYITLLDCF HAVKKAMQYG FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR
310 320 330 340 350
FIAFCGPHSR ARLESGYHQH SPETYIQYFK NHNVTTIIRL NKRMYDAKRF
360 370 380 390 400
TDAGFDHHDL FFADGSTPTD AIVKRFLDIC ENAEGAIAVH CKAGLGRTGT
410 420 430 440 450
LIACYIMKHY RMTAAETIAW VRICRPGLVI GPQQQFLVMK QTSLWLEGDY
460 470 480 490 500
FRQRLKGQEN GQHRAAFSKL LSGVDDISIN GVENQDQQEP KPYSDDDEIN
510 520 530 540 550
GVTQGDRSRA LKRRRQSKTN DILLPSPLAV LTFTLCSVVI WWIVCDYILP

ILLF
Length:554
Mass (Da):63,299
Last modified:November 24, 2009 - v2
Checksum:i22B7014D4C2A60A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71 – 88GGQAL…GRSSW → LIGRGRLQEAEKQGAVEL in BC068452 (PubMed:15489334).CuratedAdd BLAST18
Sequence conflicti75 – 78LGQW → AASR in BC028690 (PubMed:15489334).Curated4
Sequence conflicti78W → R in ABB92421 (PubMed:16201836).Curated1
Sequence conflicti93H → L in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti96P → Q in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti102S → L in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti103Q → P in BC068452 (PubMed:15489334).Curated1
Sequence conflicti103Q → P in ABB92421 (PubMed:16201836).Curated1
Sequence conflicti119R → W in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti127V → L in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti127V → L in BC028690 (PubMed:15489334).Curated1
Sequence conflicti454R → K in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti494S → G in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti494S → G in BC068452 (PubMed:15489334).Curated1
Sequence conflicti494S → G in ABB92421 (PubMed:16201836).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038327238P → S.Corresponds to variant rs1615556dbSNPEnsembl.1
Natural variantiVAR_038328296I → L.Corresponds to variant rs421206dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1.
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1.
UniGeneiHs.567757.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1.
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1.
UniGeneiHs.567757.

3D structure databases

ProteinModelPortaliA4D256.
SMRiA4D256.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

DEPODiA4D256.
iPTMnetiA4D256.
PhosphoSitePlusiA4D256.

Proteomic databases

PRIDEiA4D256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi168448.
GeneCardsiCDC14C.
H-InvDBHIX0033628.
HGNCiHGNC:22427. CDC14C.
HPAiHPA013312.
neXtProtiNX_A4D256.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG050818.
InParanoidiA4D256.
PhylomeDBiA4D256.

Enzyme and pathway databases

BioCyciZFISH:HS11321-MONOMER.

Miscellaneous databases

PROiA4D256.

Gene expression databases

CleanExiHS_CDC14C.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC14C_HUMAN
AccessioniPrimary (citable) accession number: A4D256
Secondary accession number(s): Q2VIP7, Q6NUS3, Q8NCT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May act as an autosomal functional substitute.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.