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Protein

Dual specificity protein phosphatase CDC14C

Gene

CDC14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).By similarity

Miscellaneous

May act as an autosomal functional substitute.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase CDC14CCurated (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene namesi
Name:CDC14CImported
Synonyms:CDC14B21 Publication, CDC14Bretro
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:22427. CDC14C.
neXtProtiNX_A4D256.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158221 – 447Dual specificity protein phosphatase CDC14CAdd BLAST447

Proteomic databases

PRIDEiA4D256.

PTM databases

DEPODiA4D256.
iPTMnetiA4D256.
PhosphoSitePlusiA4D256.

Expressioni

Gene expression databases

CleanExiHS_CDC14C.

Organism-specific databases

HPAiHPA013312.

Structurei

3D structure databases

ProteinModelPortaliA4D256.
SMRiA4D256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 168ABy similarityAdd BLAST155
Regioni169 – 182LinkerBy similarityAdd BLAST14
Regioni183 – 349BBy similarityAdd BLAST167

Domaini

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG050818.
InParanoidiA4D256.
PhylomeDBiA4D256.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiView protein in InterPro
IPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSTLQDPR RRDPQDDVYV DITDRLRFAI LYSRPKSASN VHYFSIDNEL
60 70 80 90 100
EYENFSEDFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH FTGSDQRKQA
110 120 130 140 150
NAAFLVGCYM VIYLGRTPEA AYRILIFGDT PYIPFRDAAY GSCNFYITLL
160 170 180 190 200
DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP
210 220 230 240 250
HSRARLESGY HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH
260 270 280 290 300
HDLFFADGST PTDAIVKRFL DICENAEGAI AVHCKAGLGR TGTLIACYIM
310 320 330 340 350
KHYRMTAAET IAWVRICRPG LVIGPQQQFL VMKQTSLWLE GDYFRQRLKG
360 370 380 390 400
QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPKPYSDDD EINGVTQGDR
410 420 430 440
SRALKRRRQS KTNDILLPSP LAVLTFTLCS VVIWWIVCDY ILPILLF
Length:447
Mass (Da):51,614
Last modified:February 28, 2018 - v3
Checksum:i962ACC30F1C6D3EF
GO

Sequence cautioni

The sequence ABB92421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL23906 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12R → W in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti20V → L in BC028690 (PubMed:15489334).Curated1
Sequence conflicti20V → L in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti347R → K in EAL23906 (PubMed:12690205).Curated1
Sequence conflicti387S → G in BC068452 (PubMed:15489334).Curated1
Sequence conflicti387S → G in ABB92421 (PubMed:16201836).Curated1
Sequence conflicti387S → G in EAL23906 (PubMed:12690205).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038327131P → S. Corresponds to variant dbSNP:rs1615556Ensembl.1
Natural variantiVAR_038328189I → L. Corresponds to variant dbSNP:rs421206Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1. Sequence problems.
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1. Different initiation.
UniGeneiHs.567757.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC14C_HUMAN
AccessioniPrimary (citable) accession number: A4D256
Secondary accession number(s): Q2VIP7, Q6NUS3, Q8NCT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 28, 2018
Last modified: February 28, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome