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A4D256 (CC14C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase CDC14C

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
CDC14 cell division cycle 14 homolog C
Gene names
Name:CDC14C
Synonyms:CDC14B2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential. Nucleusnucleolus. Note: Nucleolar during interphase By similarity.

Domain

Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

Miscellaneous

May act as an autosomal functional substitute.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Dual specificity protein phosphatase CDC14C
PRO_0000315822

Regions

Transmembrane522 – 54423Helical; Potential
Region121 – 275155A By similarity
Region276 – 28914Linker By similarity
Region290 – 456167B By similarity
Motif78 – 13154Nucleolar localization signal By similarity

Natural variations

Natural variant2381P → S.
Corresponds to variant rs1615556 [ dbSNP | Ensembl ].
VAR_038327
Natural variant2961I → L.
Corresponds to variant rs421206 [ dbSNP | Ensembl ].
VAR_038328

Experimental info

Sequence conflict71 – 8818GGQAL…GRSSW → LIGRGRLQEAEKQGAVEL in BC068452. Ref.3
Sequence conflict75 – 784LGQW → AASR in BC028690. Ref.3
Sequence conflict781W → R in ABB92421. Ref.4
Sequence conflict931H → L in EAL23906. Ref.2
Sequence conflict961P → Q in EAL23906. Ref.2
Sequence conflict1021S → L in EAL23906. Ref.2
Sequence conflict1031Q → P in BC068452. Ref.3
Sequence conflict1031Q → P in ABB92421. Ref.4
Sequence conflict1191R → W in EAL23906. Ref.2
Sequence conflict1271V → L in EAL23906. Ref.2
Sequence conflict1271V → L in BC028690. Ref.3
Sequence conflict4541R → K in EAL23906. Ref.2
Sequence conflict4941S → G in EAL23906. Ref.2
Sequence conflict4941S → G in BC068452. Ref.3
Sequence conflict4941S → G in ABB92421. Ref.4

Sequences

Sequence LengthMass (Da)Tools
A4D256 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: 22B7014D4C2A60A6

FASTA55463,299
        10         20         30         40         50         60 
MNEVSSECGK KCEPLGCSST NGDLQGEAGA VVSIFLRMVP RIKSNEGYGY SNRNWRKENT 

        70         80         90        100        110        120 
MHSLDRNIVD GGQALGQWKR KSKGRSSWAA APHCSPRCSL TSQGVKKMRS STLQDPRRRD 

       130        140        150        160        170        180 
PQDDVYVDIT DRLRFAILYS RPKSASNVHY FSIDNELEYE NFSEDFGPLN LAMVYRYCCK 

       190        200        210        220        230        240 
INKKLKSITM LRKKIVHFTG SDQRKQANAA FLVGCYMVIY LGRTPEAAYR ILIFGDTPYI 

       250        260        270        280        290        300 
PFRDAAYGSC NFYITLLDCF HAVKKAMQYG FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR 

       310        320        330        340        350        360 
FIAFCGPHSR ARLESGYHQH SPETYIQYFK NHNVTTIIRL NKRMYDAKRF TDAGFDHHDL 

       370        380        390        400        410        420 
FFADGSTPTD AIVKRFLDIC ENAEGAIAVH CKAGLGRTGT LIACYIMKHY RMTAAETIAW 

       430        440        450        460        470        480 
VRICRPGLVI GPQQQFLVMK QTSLWLEGDY FRQRLKGQEN GQHRAAFSKL LSGVDDISIN 

       490        500        510        520        530        540 
GVENQDQQEP KPYSDDDEIN GVTQGDRSRA LKRRRQSKTN DILLPSPLAV LTFTLCSVVI 

       550 
WWIVCDYILP ILLF 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-554.
Tissue: Testis.
[4]"Emergence of young human genes after a burst of retroposition in primates."
Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-536.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006024 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23906.1.
BC028690 mRNA. No translation available.
BC068452 mRNA. No translation available.
DQ120635 Genomic DNA. Translation: ABB92421.1.
UniGeneHs.567757.

3D structure databases

ProteinModelPortalA4D256.
SMRA4D256. Positions 119-456.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA4D256.

Proteomic databases

PaxDbA4D256.
PRIDEA4D256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc010kyv.1. human.

Organism-specific databases

GeneCardsGC07P048960.
H-InvDBHIX0033628.
HGNCHGNC:22427. CDC14C.
HPAHPA013312.
neXtProtNX_A4D256.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2453.
HOVERGENHBG050818.
PhylomeDBA4D256.

Gene expression databases

CleanExHS_CDC14C.
GenevestigatorA4D256.

Family and domain databases

Gene3D3.90.190.10. 2 hits.
InterProIPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA4D256.

Entry information

Entry nameCC14C_HUMAN
AccessionPrimary (citable) accession number: A4D256
Secondary accession number(s): Q2VIP7, Q6NUS3, Q8NCT2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM