A4D256 (CC14C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase CDC14C
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
CDC14 cell division cycle 14 homolog C

Gene names

Name:	CDC14C
Synonyms:	CDC14B2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Membrane; Single-pass membrane protein Potential. Nucleus › nucleolus. Note: Nucleolar during interphase By similarity.
Domain	Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Miscellaneous	May act as an autosomal functional substitute.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Dual specificity protein phosphatase CDC14C		PRO_0000315822
Regions
	Transmembrane	522 – 544	23	Helical; Potential
	Region	121 – 275	155	A By similarity
	Region	276 – 289	14	Linker By similarity
	Region	290 – 456	167	B By similarity
	Motif	78 – 131	54	Nucleolar localization signal By similarity
Natural variations
	Natural variant	238	1	P → S. Corresponds to variant rs1615556 [ dbSNP | Ensembl ].		VAR_038327
	Natural variant	296	1	I → L. Corresponds to variant rs421206 [ dbSNP | Ensembl ].		VAR_038328
Experimental info
	Sequence conflict	71 – 88	18	GGQAL…GRSSW → LIGRGRLQEAEKQGAVEL in BC068452. Ref.3
	Sequence conflict	75 – 78	4	LGQW → AASR in BC028690. Ref.3
	Sequence conflict	78	1	W → R in ABB92421. Ref.4
	Sequence conflict	93	1	H → L in EAL23906. Ref.2
	Sequence conflict	96	1	P → Q in EAL23906. Ref.2
	Sequence conflict	102	1	S → L in EAL23906. Ref.2
	Sequence conflict	103	1	Q → P in BC068452. Ref.3
	Sequence conflict	103	1	Q → P in ABB92421. Ref.4
	Sequence conflict	119	1	R → W in EAL23906. Ref.2
	Sequence conflict	127	1	V → L in EAL23906. Ref.2
	Sequence conflict	127	1	V → L in BC028690. Ref.3
	Sequence conflict	454	1	R → K in EAL23906. Ref.2
	Sequence conflict	494	1	S → G in EAL23906. Ref.2
	Sequence conflict	494	1	S → G in BC068452. Ref.3
	Sequence conflict	494	1	S → G in ABB92421. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	A4D256 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 22B7014D4C2A60A6	FASTA	554	63,299
	10 20 30 40 50 60 MNEVSSECGK KCEPLGCSST NGDLQGEAGA VVSIFLRMVP RIKSNEGYGY SNRNWRKENT 70 80 90 100 110 120 MHSLDRNIVD GGQALGQWKR KSKGRSSWAA APHCSPRCSL TSQGVKKMRS STLQDPRRRD 130 140 150 160 170 180 PQDDVYVDIT DRLRFAILYS RPKSASNVHY FSIDNELEYE NFSEDFGPLN LAMVYRYCCK 190 200 210 220 230 240 INKKLKSITM LRKKIVHFTG SDQRKQANAA FLVGCYMVIY LGRTPEAAYR ILIFGDTPYI 250 260 270 280 290 300 PFRDAAYGSC NFYITLLDCF HAVKKAMQYG FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR 310 320 330 340 350 360 FIAFCGPHSR ARLESGYHQH SPETYIQYFK NHNVTTIIRL NKRMYDAKRF TDAGFDHHDL 370 380 390 400 410 420 FFADGSTPTD AIVKRFLDIC ENAEGAIAVH CKAGLGRTGT LIACYIMKHY RMTAAETIAW 430 440 450 460 470 480 VRICRPGLVI GPQQQFLVMK QTSLWLEGDY FRQRLKGQEN GQHRAAFSKL LSGVDDISIN 490 500 510 520 530 540 GVENQDQQEP KPYSDDDEIN GVTQGDRSRA LKRRRQSKTN DILLPSPLAV LTFTLCSVVI 550 WWIVCDYILP ILLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-554. Tissue: Testis.
[4]	"Emergence of young human genes after a burst of retroposition in primates." Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H. PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-536.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC006024 Genomic DNA. No translation available. CH236955 Genomic DNA. Translation: EAL23906.1. BC028690 mRNA. No translation available. BC068452 mRNA. No translation available. DQ120635 Genomic DNA. Translation: ABB92421.1.
IPI	IPI00402094.
UniGene	Hs.567757.
3D structure databases
ProteinModelPortal	A4D256.
SMR	A4D256. Positions 119-456.
ModBase	Search...
PTM databases
PhosphoSite	A4D256.
Proteomic databases
PaxDb	A4D256.
PRIDE	A4D256.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010kyv.1. human.
Organism-specific databases
GeneCards	GC07P048960.
H-InvDB	HIX0033628.
HGNC	HGNC:22427. CDC14C.
HPA	HPA013312.
neXtProt	NX_A4D256.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2453.
HOVERGEN	HBG050818.
Gene expression databases
CleanEx	HS_CDC14C.
Genevestigator	A4D256.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR026068. Dual_Pase_CDC14. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR23339:SF27. PTHR23339:SF27. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC14C_HUMAN

Accession

Primary (citable) accession number: A4D256
Secondary accession number(s): Q2VIP7, Q6NUS3, Q8NCT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 24, 2009
Last modified:	April 3, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.