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Protein

Protein LCHN

Gene

LCHN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LCHN
Gene namesi
Name:LCHN
Synonyms:KIAA1147
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29472. KIAA1147.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi57189.
OpenTargetsiENSG00000257093.
ENSG00000262599.
PharmGKBiPA145148613.

Polymorphism and mutation databases

BioMutaiLCHN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152211 – 455Protein LCHNAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiA4D1U4.
MaxQBiA4D1U4.
PaxDbiA4D1U4.
PRIDEiA4D1U4.

PTM databases

iPTMnetiA4D1U4.
PhosphoSitePlusiA4D1U4.

Expressioni

Gene expression databases

BgeeiENSG00000257093.
CleanExiHS_KIAA1147.
ExpressionAtlasiA4D1U4. baseline and differential.
GenevisibleiA4D1U4. HS.

Organism-specific databases

HPAiHPA029467.

Interactioni

Protein-protein interaction databases

BioGridi121438. 6 interactors.
STRINGi9606.ENSP00000445768.

Structurei

3D structure databases

ProteinModelPortaliA4D1U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 39Poly-Gly10
Compositional biasi276 – 279Poly-Cys4

Sequence similaritiesi

Belongs to the LCHN family.Curated

Phylogenomic databases

eggNOGiKOG4704. Eukaryota.
ENOG410XQBR. LUCA.
GeneTreeiENSGT00590000083189.
HOGENOMiHOG000261648.
HOVERGENiHBG108083.
InParanoidiA4D1U4.
OMAiFILFFME.
OrthoDBiEOG091G0CRD.
PhylomeDBiA4D1U4.
TreeFamiTF329174.

Family and domain databases

InterProiIPR018626. DUF2347.
[Graphical view]
PfamiPF09804. DUF2347. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEQGDAAPL LRWAEGPAVS LPQAPQPQAG GWGRGGGGGA RPAAEPPRRR
60 70 80 90 100
EPEEPAAPEV LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD
110 120 130 140 150
IDLEGVEFKS MASGSHKIQS DFIYFRKGPF FGLACFANMP VESELERGAR
160 170 180 190 200
MKSVGILSPS YTLLYRYMHF LENQVRHQLE MPGHYSHLAA FYEDKKGVLH
210 220 230 240 250
AGPGRGSSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK FFGEQILILW
260 270 280 290 300
KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
310 320 330 340 350
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL
360 370 380 390 400
LKINSADREK YRRLNEQRQM LLYSQEVEED YNPCEEDLFV LFFLEQNNRI
410 420 430 440 450
FQTLLEVSAS QDKTLTAEHA RGMGLDPQGD RSFLLDLLEA YGIDVMLVID

NPCCP
Length:455
Mass (Da):51,446
Last modified:April 3, 2007 - v1
Checksum:i43449F194B74D194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA. Translation: EAL24019.1.
CH471070 Genomic DNA. Translation: EAW83974.1.
AB032973 mRNA. Translation: BAA86461.2.
CCDSiCCDS47726.1.
RefSeqiNP_001073861.1. NM_001080392.1.
UniGeneiHs.521240.

Genome annotation databases

EnsembliENST00000536163; ENSP00000445768; ENSG00000257093.
ENST00000575464; ENSP00000459381; ENSG00000262599.
GeneIDi57189.
KEGGihsa:57189.
UCSCiuc003vwk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA. Translation: EAL24019.1.
CH471070 Genomic DNA. Translation: EAW83974.1.
AB032973 mRNA. Translation: BAA86461.2.
CCDSiCCDS47726.1.
RefSeqiNP_001073861.1. NM_001080392.1.
UniGeneiHs.521240.

3D structure databases

ProteinModelPortaliA4D1U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121438. 6 interactors.
STRINGi9606.ENSP00000445768.

PTM databases

iPTMnetiA4D1U4.
PhosphoSitePlusiA4D1U4.

Polymorphism and mutation databases

BioMutaiLCHN.

Proteomic databases

EPDiA4D1U4.
MaxQBiA4D1U4.
PaxDbiA4D1U4.
PRIDEiA4D1U4.

Protocols and materials databases

DNASUi57189.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536163; ENSP00000445768; ENSG00000257093.
ENST00000575464; ENSP00000459381; ENSG00000262599.
GeneIDi57189.
KEGGihsa:57189.
UCSCiuc003vwk.3. human.

Organism-specific databases

CTDi57189.
DisGeNETi57189.
GeneCardsiKIAA1147.
H-InvDBHIX0007153.
HGNCiHGNC:29472. KIAA1147.
HPAiHPA029467.
neXtProtiNX_A4D1U4.
OpenTargetsiENSG00000257093.
ENSG00000262599.
PharmGKBiPA145148613.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4704. Eukaryota.
ENOG410XQBR. LUCA.
GeneTreeiENSGT00590000083189.
HOGENOMiHOG000261648.
HOVERGENiHBG108083.
InParanoidiA4D1U4.
OMAiFILFFME.
OrthoDBiEOG091G0CRD.
PhylomeDBiA4D1U4.
TreeFamiTF329174.

Miscellaneous databases

ChiTaRSiKIAA1147. human.
GenomeRNAii57189.
PROiA4D1U4.

Gene expression databases

BgeeiENSG00000257093.
CleanExiHS_KIAA1147.
ExpressionAtlasiA4D1U4. baseline and differential.
GenevisibleiA4D1U4. HS.

Family and domain databases

InterProiIPR018626. DUF2347.
[Graphical view]
PfamiPF09804. DUF2347. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCHN_HUMAN
AccessioniPrimary (citable) accession number: A4D1U4
Secondary accession number(s): Q9ULS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.