A4D1S5 (RAB19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-19

Gene names

Name:	RAB19
Synonyms:	RAB19B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A4D1S5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A4D1S5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: K → KNSSASIITFASIQIHGQTQKMSPQIWTKSSHYLWEPLIWTLLPVLLQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Ras-related protein Rab-19		PRO_0000300459
Regions
	Nucleotide binding	24 – 31	8	GTP By similarity
	Nucleotide binding	72 – 76	5	GTP By similarity
	Nucleotide binding	130 – 133	4	GTP By similarity
	Motif	46 – 54	9	Effector region By similarity
Amino acid modifications
	Modified residue	217	1	Cysteine methyl ester By similarity
	Lipidation	215	1	S-geranylgeranyl cysteine By similarity
	Lipidation	217	1	S-geranylgeranyl cysteine By similarity
Natural variations
	Alternative sequence	67	1	K → KNSSASIITFASIQIHGQTQ KMSPQIWTKSSHYLWEPLIW TLLPVLLQ in isoform 2.		VSP_036588
Experimental info
	Sequence conflict	31	1	T → S in AAF00046. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 787695528A6EE366	FASTA	217	24,400
	10 20 30 40 50 60 MHFSSSARAA DENFDYLFKI ILIGDSNVGK TCVVQHFKSG VYTETQQNTI GVDFTVRSLD 70 80 90 100 110 120 IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESIPH WIHEIEKYGA 130 140 150 160 170 180 ANVVIMLIGN KCDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESKNIEE VFVLMAKELI 190 200 210 ARNSLHLYGE SALNGLPLDS SPVLMAQGPS EKTHCTC
	Isoform 2 [UniParc]. Checksum: 80C094721C166813	FASTA	264	29,776
	10 20 30 40 50 60 MHFSSSARAA DENFDYLFKI ILIGDSNVGK TCVVQHFKSG VYTETQQNTI GVDFTVRSLD 70 80 90 100 110 120 IDGKKVKNSS ASIITFASIQ IHGQTQKMSP QIWTKSSHYL WEPLIWTLLP VLLQMQVWDT 130 140 150 160 170 180 AGQERFRTIT QSYYRSAHAA IIAYDLTRRS TFESIPHWIH EIEKYGAANV VIMLIGNKCD 190 200 210 220 230 240 LWEKRHVLFE DACTLAEKYG LLAVLETSAK ESKNIEEVFV LMAKELIARN SLHLYGESAL 250 260 NGLPLDSSPV LMAQGPSEKT HCTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Rab GTPases expressed in Caco-2 cells." Opdam F.J.M., van Bokhoven H., Kamps G., Ginsel L.A., Fransen J.A.M. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-71 (ISOFORM 1). Tissue: Colon carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC069335 Genomic DNA. No translation available. AC093087 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24028.1. CH236950 Genomic DNA. Translation: EAL24029.1. BC140796 mRNA. Translation: AAI40797.1. AF091033 mRNA. Translation: AAF00046.1.
IPI	IPI00478209. IPI00923598.
RefSeq	NP_001008749.2. NM_001008749.2.
UniGene	Hs.583545.
3D structure databases
ProteinModelPortal	A4D1S5.
SMR	A4D1S5. Positions 14-183.
ModBase	Search...
Protein-protein interaction databases
STRING	A4D1S5.
PTM databases
PhosphoSite	A4D1S5.
Proteomic databases
PRIDE	A4D1S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356407; ENSP00000348778; ENSG00000146955.
GeneID	401409.
KEGG	hsa:401409.
UCSC	uc010lni.1. human.
Organism-specific databases
CTD	401409.
GeneCards	GC07P140103.
HGNC	HGNC:19982. RAB19.
neXtProt	NX_A4D1S5.
PharmGKB	PA162400617.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14473.
HOVERGEN	HBG009351.
OMA	GNKCDLW.
PhylomeDB	A4D1S5.
Gene expression databases
Bgee	A4D1S5.
CleanEx	HS_RAB19.
Genevestigator	A4D1S5.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAB19_HUMAN

Accession

Primary (citable) accession number: A4D1S5
Secondary accession number(s): A4D1S6 , B2RTS6, B5MDR2, Q9UL27

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.