ID KLRG2_HUMAN Reviewed; 409 AA. AC A4D1S0; Q2NL79; Q6ZTV6; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 11-JAN-2011, sequence version 3. DT 24-JAN-2024, entry version 121. DE RecName: Full=Killer cell lectin-like receptor subfamily G member 2; DE AltName: Full=C-type lectin domain family 15 member B; GN Name=KLRG2; Synonyms=CLEC15B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-152. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=A4D1S0-1; Sequence=Displayed; CC Name=2; CC IsoId=A4D1S0-2; Sequence=VSP_030779, VSP_030780; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK126174; BAC86473.1; -; mRNA. DR EMBL; AC005531; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236950; EAL24036.1; -; Genomic_DNA. DR EMBL; BC104963; AAI04964.1; -; mRNA. DR EMBL; BC104965; AAI04966.1; -; mRNA. DR EMBL; BC110858; AAI10859.1; -; mRNA. DR CCDS; CCDS5854.1; -. [A4D1S0-1] DR RefSeq; NP_940910.1; NM_198508.2. [A4D1S0-1] DR AlphaFoldDB; A4D1S0; -. DR SMR; A4D1S0; -. DR BioGRID; 131397; 108. DR IntAct; A4D1S0; 52. DR MINT; A4D1S0; -. DR STRING; 9606.ENSP00000339356; -. DR iPTMnet; A4D1S0; -. DR PhosphoSitePlus; A4D1S0; -. DR BioMuta; KLRG2; -. DR EPD; A4D1S0; -. DR jPOST; A4D1S0; -. DR MassIVE; A4D1S0; -. DR MaxQB; A4D1S0; -. DR PaxDb; 9606-ENSP00000339356; -. DR PeptideAtlas; A4D1S0; -. DR ProteomicsDB; 627; -. [A4D1S0-1] DR ProteomicsDB; 628; -. [A4D1S0-2] DR Antibodypedia; 2744; 89 antibodies from 17 providers. DR DNASU; 346689; -. DR Ensembl; ENST00000340940.5; ENSP00000339356.4; ENSG00000188883.5. [A4D1S0-1] DR Ensembl; ENST00000393039.2; ENSP00000376759.2; ENSG00000188883.5. [A4D1S0-2] DR GeneID; 346689; -. DR KEGG; hsa:346689; -. DR MANE-Select; ENST00000340940.5; ENSP00000339356.4; NM_198508.4; NP_940910.1. DR UCSC; uc003vvb.4; human. [A4D1S0-1] DR AGR; HGNC:24778; -. DR CTD; 346689; -. DR DisGeNET; 346689; -. DR GeneCards; KLRG2; -. DR HGNC; HGNC:24778; KLRG2. DR HPA; ENSG00000188883; Tissue enhanced (esophagus, salivary gland, thyroid gland). DR neXtProt; NX_A4D1S0; -. DR OpenTargets; ENSG00000188883; -. DR PharmGKB; PA162393624; -. DR VEuPathDB; HostDB:ENSG00000188883; -. DR eggNOG; KOG4297; Eukaryota. DR GeneTree; ENSGT00940000162997; -. DR HOGENOM; CLU_049894_8_6_1; -. DR InParanoid; A4D1S0; -. DR OMA; GLPMYVK; -. DR OrthoDB; 4553585at2759; -. DR PhylomeDB; A4D1S0; -. DR TreeFam; TF351467; -. DR PathwayCommons; A4D1S0; -. DR SignaLink; A4D1S0; -. DR BioGRID-ORCS; 346689; 15 hits in 1154 CRISPR screens. DR ChiTaRS; KLRG2; human. DR GenomeRNAi; 346689; -. DR Pharos; A4D1S0; Tdark. DR PRO; PR:A4D1S0; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; A4D1S0; Protein. DR Bgee; ENSG00000188883; Expressed in primordial germ cell in gonad and 48 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW. DR CDD; cd03593; CLECT_NK_receptors_like; 1. DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR043318; KLRG2. DR InterPro; IPR033992; NKR-like_CTLD. DR PANTHER; PTHR47606; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2; 1. DR PANTHER; PTHR47606:SF1; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2; 1. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR SUPFAM; SSF56436; C-type lectin-like; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. PE 1: Evidence at protein level; KW Alternative splicing; Disulfide bond; Lectin; Membrane; Phosphoprotein; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..409 FT /note="Killer cell lectin-like receptor subfamily G member FT 2" FT /id="PRO_0000316792" FT TRANSMEM 263..283 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 300..405 FT /note="C-type lectin" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040" FT REGION 1..120 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 193..216 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 158 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q3UM83" FT DISULFID 321..404 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040" FT DISULFID 383..396 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040" FT VAR_SEQ 253..312 FT /note="GLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHC FT YYFSAEAQ -> DSLRTARTIWISTVGPWRKARWWLQTAALQDPGSVPRGPSDLGSAWS FT SACQADAAPPTGEAS (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_030779" FT VAR_SEQ 313..409 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_030780" FT VARIANT 152 FT /note="K -> T (in dbSNP:rs1860150)" FT /evidence="ECO:0000269|PubMed:12690205" FT /id="VAR_038396" FT VARIANT 339 FT /note="G -> A (in dbSNP:rs17160911)" FT /id="VAR_038397" FT CONFLICT 109 FT /note="A -> V (in Ref. 3; EAL24036)" FT /evidence="ECO:0000305" SQ SEQUENCE 409 AA; 42851 MW; E4AD53ED44E1240E CRC64; MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD GDEKLPRAVT LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG AWRGPQGWHW IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR PWVCAKGTQ //